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The protein encoded by ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. Zusätzlich bieten wir Ihnen ALDH1L1 Antikörper (132) und ALDH1L1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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The crystal structures of apo (zeige C9orf3 ELISA Kits)-form N-terminal domain - FDH and its complexes with the substrate analogue 10-formyl-5,8-dideazafolate (10-FDDF) and with the products tetrahydrofolate and formate have been determined.
Knock-down of the fdh(10-Formyltetrahydrofolate dehydrogenase) gene impeded morphogenetic movement and caused incorrect cardiac positioning, defective hematopoiesis, notochord malformation and ultimate death of morphants
The polymorphic loci rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene maybe potential risk factors for neural tube defects in the Chinese population.
Data suggest that isoforms of FTHFD occur both in mitochondria and in cytosol; activity of cytosolic FTHFD appears to respond to supply of one-carbon groups in excess of those required for classical one-carbon metabolism. [REVIEW]
JNK1 (zeige MAPK8 ELISA Kits)/2 phosphorylate Bid (zeige BID ELISA Kits) at Thr59 within the caspase (zeige CASP3 ELISA Kits) cleavage site in response to ALDH1L1.
ALDH1 (zeige ALDH1A1 ELISA Kits) is indicative of stemness and is a biomarker marker in colon cancer.
one variant in the ALDH1L1 locus, rs2364368, was associated with incident ischemic stroke.
The results in this study, for the first time, reveal that the mRNA and protein expressions of ALDH1L1 are significantly reduced in hepatocellular carcinoma tissues
Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme.
These studies support ALDH1L1 as a general CNS astroglial marker.
inhibition of cell motility by ALDH1L1 associated with dephosphorylation of the actin depolymerizing factor cofilin (zeige CFL1 ELISA Kits) by PP1 (zeige PPA1 ELISA Kits) and PP2A (zeige PPP2R4 ELISA Kits)
down-regulation of FDH (zeige ADH5 ELISA Kits) in tumors is proposed to be one of the cellular mechanisms that enhance proliferation.
Collectively, MNSFbeta (zeige FAU ELISA Kits)/FDH (zeige ADH5 ELISA Kits) complex formation may positively regulate apoptosis in thymocytes.
Aldh1L1 is not a suitable marker for enteric glial cells.
This study demonistrated that Aldh1L1 is expressed by postnatal neural stem cells in mice.
These data provide the first evidence for localized differences in folate metabolism within the early neural tube and suggest that folate might modulate proliferation via effects on midline Aldh1l1(+) cells.
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
, 10-formyltetrahydrofolate dehydrogenase
, aldehyde dehydrogenase 1L1
, aldehyde dehydrogenase family 1 member L1
, cytosolic 10-formyltetrahydrofolate dehydrogenase
, formyltetrahydrofolate dehydrogenase
, aldehyde dehydrogenase 1 family, member L1
, 10-formyltetrahydrofolate dehydrogenase-like