anti-Acyl-CoA Synthetase Short-Chain Family Member 2 (ACSS2) Antikörper

ACSS2 encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. Zusätzlich bieten wir Ihnen ACSS2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ACSS2 55902 Q9NR19
ACSS2 60525 Q9QXG4
ACSS2 311569  
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Top anti-ACSS2 Antikörper auf antikoerper-online.de

Showing 10 out of 87 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-ACSS2 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: HT1080 Whole Cell 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of ACSS2 Antibody (N-term) in K562 cell line lysates (35 µg/lane).ACSS2 (arrow) was detected using the purified Pab. Western blot analysis of ACSS2 Antibody (N-term) in mouse liver tissue lysates (35 µg/lane). ACSS2 (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of ACSS2 Antibody (N-term) (ABIN653559) in K562 cell line lysates (35 µg/lane).ACSS2 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of ACSS2 Antibody (N-term) (ABIN653559) in mouse liver tissue lysates (35 µg/lane). ACSS2 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB ACSS2 Antibody (Center) (ABIN657155) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the ACSS2 antibody detected the ACSS2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IC, IF, WB Immunofluorescent analysis of ACAS2 staining in SW620 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Western blot analysis of ACAS2 expression in HepG2 (A), SW620 (B), mouse liver (C), mouse kidney (D), rat brain (E) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Meerschweinchen Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
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Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Maus Unkonjugiert WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ACSS2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ACSS2. 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$423.50
Details
Human Maus Unkonjugiert IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ACSS2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ACSS2. Immunohistochemical staining of paraffin-embedded Human tonsil using anti-ACSS2 mouse monoclonal antibody. (ABIN2455072) 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$423.50
Details

ACSS2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen ACSS2 Interaktionspartner

Human Acyl-CoA Synthetase Short-Chain Family Member 2 (ACSS2) Interaktionspartner

  1. In a Honduran population, the odds of having nonsyndromic cleft lip/palate (NSCLP) among carriers of the ACSS2 variant was 4.0 with a carrier frequency of 7.1% in unrelated affected and 1.9% in unrelated unaffected individuals. In a Colombian population, the odds of having NSCLP among carriers of the ACSS2 variant was 2.6 with a carrier frequency of 10.0% in unrelated affected and 4.1% in unrelated unaffected individuals.

  2. In the nucleus, ACSS2 binds to transcription factor EB (zeige TFEB Antikörper) and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA (zeige LPCAT2 Antikörper) for histone H3 (zeige HIST3H3 Antikörper) acetylation in these regions and promote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis.

  3. ACSS2 is essential for glucose-independent acetate-mediated cell survival and tumor growth.

  4. Loss of ACSS2 expression is associated with with gastric cancer.

  5. Study revealed that the activity of acetyl-CoA synthetase 2 (zeige ACSS1 Antikörper) (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.

  6. Observations suggest that ACSS2 is expressed to a significant extent in particular tumor types, including triple-negative breast cancers.

  7. Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine (zeige GFPT1 Antikörper). In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2.

  8. During hypoxia, ACSS2 modulates interactions (zeige LPCAT2 Antikörper)of the acetylase/coactivator CBP with the stress-responsive transcription fa (zeige CREBBP Antikörper)ctor, HIF-2. These int (zeige CREBBP Antikörper)eractions include acetylation of HIF-2 by CBP as well as stable HIF-2/CBP comple (zeige EPO Antikörper)x formation, both of which are required for maximal HIF-2 signaling. Thus, ACSS2 links changes in metabolism that occur during stress with activation of a selective nuclear signaling pathway.

  9. Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated acyl-CoA synthetase short-chain family member 2 in 20 healthy individuals.

  10. Because the activity of a bacterial ortholog of AceCS2 (zeige ACSS1 Antikörper), called ACS (zeige PLA2G15 Antikörper), is controlled via deacetylation by a bacterial sirtuin (zeige SIRT1 Antikörper) protein, our observation highlights the conservation of a metabolic regulatory pathway from bacteria to humans

Mouse (Murine) Acyl-CoA Synthetase Short-Chain Family Member 2 (ACSS2) Interaktionspartner

  1. results reveal a connection between cellular metabolism, gene regulation, and neural plasticity and establish a link between acetyl-CoA (zeige LPCAT1 Antikörper) generation 'on-site' at chromatin for histone acetylation and the transcription of key neuronal genes.

  2. Study revealed that the activity of acetyl-CoA synthetase 2 (zeige ACSS1 Antikörper) (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.

  3. Study reports evidence that the nucleocytosolic ACSS2 enzyme is of critical importance for mammalian cells to utilize acetate as a source of acetyl-CoA (zeige LPCAT1 Antikörper), and that mice lacking this enzyme exhibit a substantial reduction in tumor burden in two genetic models of liver cancer.

  4. Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine (zeige GFPT1 Antikörper). In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase (zeige Acsl1 Antikörper) enzyme 2, ACSS2.

  5. Acss2 generates a specific pool of acetyl CoA (zeige LPCAT1 Antikörper) during hypoxia that modulates interactions of the acetylase/coactivator Cbp (zeige CREBBP Antikörper) (also known as Crebbp (zeige CREBBP Antikörper)) with the stress-responsive transcription factor, Hif-2. Because erythropoietin (zeige EPO Antikörper) is a Hif-2 target gene, red blood cell production in mice is also regulated by Acss2. Recovery from anemia is accelerated by administering acetate, although this requires the presence of Acss2.

  6. Acetyl CoA synthetase-1 (AceCS1) is mainly expressed in oligodendrocytes in the rat brain. It is located both in cytosol and nucleus of mammalian cells.

  7. Expression of cytosolic acetyl-CoA synthetase gene in mice is developmentally regulated

  8. ACSS2 might play a buffering role in tumor acetyl-CoA (zeige LPCAT1 Antikörper)/acetate metabolism

ACSS2 Antigen-Profil

Protein Überblick

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit ACSS2

  • acyl-CoA synthetase short-chain family member 2 (ACSS2) Antikörper
  • acyl-CoA synthetase short-chain family member 2 (acss2) Antikörper
  • acyl-CoA synthetase short-chain family member 2 (Acss2) Antikörper
  • 1110017C11Rik Antikörper
  • ACAS Antikörper
  • Acas1 Antikörper
  • Acas2 Antikörper
  • ACECS Antikörper
  • AceCS1 Antikörper
  • ACS Antikörper
  • Acs1 Antikörper
  • ACSA Antikörper
  • dJ1161H23.1 Antikörper
  • wu:fa04c03 Antikörper
  • wu:fj80b06 Antikörper
  • wu:fj80h04 Antikörper
  • zgc:92200 Antikörper

Bezeichner auf Proteinebene für ACSS2

acyl-CoA synthetase short-chain family member 2 , acetyl-coenzyme A synthetase, cytoplasmic , acetyl-coenzyme A synthetase, cytoplasmic-like , fa04c03 , fj80b06 , fj80h04 , acetyl-CoA synthetase 2 , acetate thiokinase , acetate-CoA ligase , acetyl-Coenzyme A synthetase 2 (ADP forming) , acyl-activating enzyme , cytoplasmic acetyl-coenzyme A synthetase , ACS , aceCS , acetate--CoA ligase , acetyl-CoA synthetase 1 , acetyl-Coenzyme A synthetase 1 (AMP forming) , acetyl-Coenzyme A synthetase 2 (AMP forming)

GENE ID SPEZIES
477205 Canis lupus familiaris
506459 Bos taurus
100032395 Monodelphis domestica
100054562 Equus caballus
100179555 Ciona intestinalis
100211402 Hydra magnipapillata
100224916 Taeniopygia guttata
100455504 Pongo abelii
100481825 Ailuropoda melanoleuca
419158 Gallus gallus
436914 Danio rerio
458441 Pan troglodytes
706703 Macaca mulatta
780456 Ovis aries
100153866 Sus scrofa
100346003 Oryctolagus cuniculus
100411267 Callithrix jacchus
100542964 Meleagris gallopavo
100604921 Nomascus leucogenys
55902 Homo sapiens
60525 Mus musculus
311569 Rattus norvegicus
Ausgewählte Anbieter für anti-ACSS2 (ACSS2) Antikörper
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