Acyl-CoA Synthetase Long-Chain Family Member 5 Proteine (ACSL5)

The protein encoded by ACSL5 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Zusätzlich bieten wir Ihnen ACSL5 Antikörper (54) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ACSL5 51703 Q9ULC5
ACSL5 433256 Q8JZR0
ACSL5 94340 O88813
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Showing 5 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 56 bis 61 Tage
5.753,97 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.701,59 €
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ACSL5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)
,
Rat (Rattus)

Weitere Proteine zu Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) Interaktionspartnern

Human Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) Interaktionspartner

  1. Functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping was identified as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Delta20 molecules is involved in migraine pathology.

  2. colorectal adenocarcinomas with low (n=41; group 1) or high (n=31; group 2) ACSL5 levels were identified. In a one-year follow-up, tumour recurrence was significantly increased in group 1.

  3. ACSL5 mediates antiproliferative activities via Wnt2B (zeige WNT2B Proteine) palmitoylation with diminished Wnt (zeige WNT2 Proteine) activity. The molecular pathway is probably relevant for intestinal homeostasis, overwhelmed by other pathways in carcinogenesis.

  4. Uncoupling of ACSL5 and mitochondrial mortalin (zeige HSPA9 Proteine) by mutated TP53 (zeige TP53 Proteine) could be important in colorectal carcinogenesis.

  5. Down-regulation of ACSL5 is associated with colorectal cancer.

  6. Levels of acyl-coenzyme A (zeige SOAT2 Proteine) synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.

  7. High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells

  8. The data strongly indicate that human but not rat acyl-CoA synthetase 5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms.

  9. Increased ACSL5 is associated with Fatty Liver.

  10. expression of ACS5 in the gastric body and the small intestine with metaplasia or heterotopia

Mouse (Murine) Acyl-CoA Synthetase Long-Chain Family Member 5 (ACSL5) Interaktionspartner

  1. Acsl5 is a major activator of dietary long chain fatty acids , yet in Acsl5 KO mice residual ACS activity is sufficient for maintaining a normal long chain fatty acids absorption.

  2. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth

ACSL5 Protein Überblick

Protein Überblick

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit ACSL5

  • acyl-CoA synthetase long-chain family member 5 (ACSL5)
  • acyl-CoA synthetase long-chain family member 5 (acsl5)
  • acyl-CoA synthetase long-chain family member 5 (LOC100217956)
  • acyl-CoA synthetase long-chain family member 5 (Acsl5)
  • 1700030F05Rik Protein
  • ACS2 Protein
  • Acs5 Protein
  • ACSL5 Protein
  • Facl5 Protein
  • zgc:92083 Protein

Bezeichner auf Proteinebene für ACSL5

acyl-CoA synthetase long-chain family member 5 , long-chain-fatty-acid--CoA ligase 5 , acyl-CoA synthetase 5 , long-chain-fatty-acid--CoA ligase 5-like , FACL5 for fatty acid coenzyme A ligase 5 , LACS 5 , fatty acid coenzyme A ligase 5 , fatty-acid-Coenzyme A ligase, long-chain 5 , long-chain acyl-CoA synthetase 5 , long-chain fatty acid coenzyme A ligase 5 , fatty acid Coenzyme A ligase, long chain 5

GENE ID SPEZIES
450739 Pan troglodytes
496479 Xenopus (Silurana) tropicalis
100059190 Equus caballus
100082580 Ornithorhynchus anatinus
100217956 Taeniopygia guttata
100379229 Cavia porcellus
100434441 Pongo abelii
100472737 Ailuropoda melanoleuca
100548195 Meleagris gallopavo
100561703 Anolis carolinensis
100587448 Nomascus leucogenys
51703 Homo sapiens
433256 Mus musculus
94340 Rattus norvegicus
447860 Danio rerio
423896 Gallus gallus
477820 Canis lupus familiaris
100157521 Sus scrofa
514159 Bos taurus
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