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The protein encoded by ACSL5 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Zusätzlich bieten wir Ihnen ACSL5 Antikörper (54) und viele weitere Produktgruppen zu diesem Protein an.
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Functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping was identified as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Delta20 molecules is involved in migraine pathology.
colorectal adenocarcinomas with low (n=41; group 1) or high (n=31; group 2) ACSL5 levels were identified. In a one-year follow-up, tumour recurrence was significantly increased in group 1.
ACSL5 mediates antiproliferative activities via Wnt2B (zeige WNT2B Proteine) palmitoylation with diminished Wnt (zeige WNT2 Proteine) activity. The molecular pathway is probably relevant for intestinal homeostasis, overwhelmed by other pathways in carcinogenesis.
Uncoupling of ACSL5 and mitochondrial mortalin (zeige HSPA9 Proteine) by mutated TP53 (zeige TP53 Proteine) could be important in colorectal carcinogenesis.
Down-regulation of ACSL5 is associated with colorectal cancer.
Levels of acyl-coenzyme A (zeige SOAT2 Proteine) synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.
High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells
The data strongly indicate that human but not rat acyl-CoA synthetase 5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms.
Increased ACSL5 is associated with Fatty Liver.
expression of ACS5 in the gastric body and the small intestine with metaplasia or heterotopia
Acsl5 is a major activator of dietary long chain fatty acids , yet in Acsl5 KO mice residual ACS activity is sufficient for maintaining a normal long chain fatty acids absorption.
Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.
acyl-CoA synthetase long-chain family member 5
, long-chain-fatty-acid--CoA ligase 5
, acyl-CoA synthetase 5
, long-chain-fatty-acid--CoA ligase 5-like
, FACL5 for fatty acid coenzyme A ligase 5
, LACS 5
, fatty acid coenzyme A ligase 5
, fatty-acid-Coenzyme A ligase, long-chain 5
, long-chain acyl-CoA synthetase 5
, long-chain fatty acid coenzyme A ligase 5
, fatty acid Coenzyme A ligase, long chain 5