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The protein encoded by ABCG1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ABCG1 Kits (33) und ABCG1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
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Chinese Hamster Polyclonal ABCG1 Primary Antibody für ICC, IF - ABIN152900
Hu, Abe-Dohmae, Tsujita, Iwamoto, Ogikubo, Otsuka, Kumon, Yokoyama: Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo. in Journal of lipid research 2008
Show all 99 Pubmed References
Human Polyclonal ABCG1 Primary Antibody für IF (p), IHC (p) - ABIN673719
Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (zeige SCARB1 Antikörper) or ABCG1 but not ABCA1 (zeige ABCA1 Antikörper).
Hepatic free cholesterol content was significantly increased in NASH (zeige SAMSN1 Antikörper) as compared to non-NASH (zeige SAMSN1 Antikörper) subjects, while ABCA1 (zeige ABCA1 Antikörper) and ABCG1 protein levels significantly decreased with NASH (zeige SAMSN1 Antikörper) and fibrosis progression. The relative expression of miR (zeige MLXIP Antikörper)-33a and miR (zeige MLXIP Antikörper)-144 correlated inversely with ABCA1 (zeige ABCA1 Antikörper) but not with ABCG1 protein levels. miR (zeige MLXIP Antikörper)-33a/144 and their target gene ABCA1 (zeige ABCA1 Antikörper) may contribute to the pathogenesis of NASH (zeige SAMSN1 Antikörper) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (zeige ABCB6 Antikörper) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
Findings suggest that the ABCG1-mediated efflux of cholesterol, but not of 7-ketocholesterol, shows specificity for structural domains of apoA-I (zeige APOA1 Antikörper) bound to reconstituted HDL (zeige HSD11B1 Antikörper). Although the mid region alone of apoA-I (zeige APOA1 Antikörper) associated to rHDL can promote ABCG1-mediated cholesterol efflux, deletion of carboxyl-terminal region 185-243 from full-length apoA-I (zeige APOA1 Antikörper) diminishes ABCG1-mediated cholesterol efflux.
ABCG1 regulates T cell differentiation into Tregs, highlighting a pathway by which cholesterol accumulation can influence T cell homeostasis in atherosclerosis
Data show that ELOVL7 (zeige ELOVL7 Antikörper), SOCS3 (zeige SOCS3 Antikörper), ACSL4 (zeige ACSL4 Antikörper) and CLU (zeige CLU Antikörper) were upregulated while PRKAR1A (zeige PRKAR1A Antikörper) and ABCG1 were downregulated in the phlegm-dampness group.
ABCG1 and ABCG4 (zeige ABCG4 Antikörper) alter the distribution of gamma-secretase on the plasma membrane, leading to the decreased gamma-secretase activity and suppressed Abeta (zeige APP Antikörper) secretion
Both the full-length and the short isoforms of ABCG1 can dimerize with ABCG4 (zeige ABCG4 Antikörper), whereas the ABCG2 (zeige ABCG2 Antikörper) multidrug transporter is unable to form a heterodimer with ABCG4 (zeige ABCG4 Antikörper).
DNA methylation (zeige HELLS Antikörper) at the ABCG1 locus cg06500161 in blood DNA was associated with an increased risk for future type2 diabetes.
we have newly identified a haplotype-tagging SNP, rs225396, in ABCG1 to be associated with PCV and nAMD in Chinese and Japanese cohorts. This provides new evidence to support ABCG1 as a susceptibility gene for PCV and nAMD.
ABCG1 gene expression positively correlated with obesity indicators.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (zeige NR1H3 Antikörper)-ABCA1 (zeige ABCA1 Antikörper)/ABCG1 cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (zeige HSD11B1 Antikörper)-C levels observed in patients receiving both medications
ABCG1 may play a protective role in early-stage atherosclerosis by reducing endothelial activation induced by oscillatory shear stress via suppressing the inflammatory response.
Endothelial cholesterol efflux pathways mediated by ABCA1 (zeige ABCA1 Antikörper) and ABCG1 are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase (zeige NOS Antikörper) activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.
ABCG1, irrespective of either a leucine or proline at position 550, is an intracellular protein (zeige CKAP2 Antikörper) that localizes to vesicles of the endosomal pathway where it functions to mobilize sterols away from the endoplasmic reticulum and out of the cell.
our study suggests that MEK1 (zeige MAP2K1 Antikörper)/2 inhibitors activate macrophage ABCG1 expression/RCT (zeige FOXE3 Antikörper), and inhibit foam cell formation and lesion development by multiple mechanisms, supporting the concept that ERK1/2 (zeige MAPK1/3 Antikörper) inhibition is anti-atherogenic
miR-33 augments macrophage lipid rafts and enhances proinflammatory cytokine induction and NF-kappaB activation by LPS. This occurs through an ABCA1- and ABCG1-dependent mechanism and is reversible by interventions upon raft cholesterol and by ABC transporter-inducing liver X receptor agonists.
ABCG1 expression was down-regulated by TLR4 (zeige TLR4 Antikörper), which induces inflammation and lipid accumulation in vascular smooth muscle cells via PPARgamma (zeige PPARG Antikörper)/LXRalpha (zeige NR1H3 Antikörper) signaling.
Visfatin (zeige NAMPT Antikörper) upregulated CD36 (zeige CD36 Antikörper) and SRA (zeige MSR1 Antikörper) expression and downregulated ABCA1 (zeige ABCA1 Antikörper) and ABCG1 expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (zeige EPHB2 Antikörper)-dependent pathways.
Leu at position 550/562 in mABCG1/hABCG1 is critical for their plasma membrane localization but not for ABCG1-mediated cholesterol efflux.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.
ATP-binding cassette sub-family G member 1
, ATP-binding cassette, sub-family G (WHITE), member 1
, ATP-binding cassette sub-family G member 1-like
, ABC transporter 8
, ATP-binding cassette transporter 8
, ATP-binding cassette transporter member 1 of subfamily G
, homolog of Drosophila white
, white protein homolog (ATP-binding cassette transporter 8)
, ATP-binding cassette 8
, ATP-binding cassette, subfamily G, member 1
, white protein homolog