anti-TPP1 (TPP1) Antikörper

Bezeichnung:: anti-Tripeptidyl Peptidase I Antikörper (TPP1)

Auf www.antikoerper-online.de finden Sie aktuell 108 Tripeptidyl Peptidase I (TPP1) Antikörper von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TPP1 Kits (19) und TPP1 Proteine (15) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 151 TPP1 Produkte verfügbar.

Synonyme:: Cln2, fa01b09, im:7149243, LPIC, TPP-1, TPP-I, wu:fa01b09

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	TPP1	1200	O14773
	TPP1	83534	Q9EQV6
	TPP1	12751	O89023
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Rat (Rattus) TPP1 Antikörper:

anti-Mouse (Murine) TPP1 Antikörper:

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Am meisten referenzierte anti-TPP1 Antikörper

Human Polyclonal TPP1 Primary Antibody für IF (p) - ABIN1417442 : Brenneman, Pearce, Kovacs, DeFrees: Pharmacological Effects on Ceroid Lipofuscin and Neuronal Structure in Cln3∆ex7/8Mouse Brain Cultures. in Journal of molecular neuroscience : MN 2017 (PubMed)
Human Polyclonal TPP1 Primary Antibody für ICC, IF - ABIN451783 : Kousi, Siintola, Dvorakova, Vlaskova, Turnbull, Topcu, Yuksel, Gokben, Minassian, Elleder, Mole, Lehesjoki: Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis. in Brain : a journal of neurology 2009 (PubMed)
Human Monoclonal TPP1 Primary Antibody für IHC (p), ELISA - ABIN560411 : Qing, Zhou, Zhao, Xie, Yang, Xing, Zeng, Jiang: Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis. in Rheumatology international 2012 (PubMed)

Weitere Antikörper gegen TPP1 Interaktionspartner

Human Tripeptidyl Peptidase I (TPP1) Interaktionspartner

To confirm clinical suspicion of CLN2 disease, the recommended gold standard for laboratory diagnosis is demonstration of deficient TPP1 enzyme activity (in leukocytes, fibroblasts, or dried blood spots) and the identification of causative mutations in each allele of the TPP1/CLN2 gene.
Binding of POT1 (zeige POT1 Antikörper)-TPP1 unfolds telomere secondary structure to assist loading of additional heterodimers.
Together, these functional data combined with biophysical analyses and homology modeling provide a molecular understanding of the diverse contributions of TPP1 in telomere maintenance.
These studies indicate that optimal treatment outcomes for CLN2 disease may require delivery of TPP1 systemically as well as directly to the central nervous system.
TPP1 is overexpressed in hepatocellular carcinoma tissues and significantly correlated with poor prognosis of hepatocellular carcinoma patients.RFX5 acts as a direct positive transcriptional regulator of TPP1 in hepatocellular carcinoma.
We found that NEK6 (zeige NEK6 Antikörper)-mediated phosphorylation of TPP1 Ser255 in G2/M phase regulates the association between telomerase activity and TPP1. Furthermore, we found evidence that POT1 (zeige POT1 Antikörper) negatively regulates TPP1 phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 (zeige POT1 Antikörper) mutant lacking its OB-fold domains
The conservation between fission yeast Tpz1-Pot1 (zeige POT1 Antikörper) and human TPP1-POT1 (zeige POT1 Antikörper) interactions resulted in mapping a human melanoma-associated (zeige ZNF654 Antikörper) POT1 (zeige POT1 Antikörper) mutation (A532P) to the TPP1-POT1 (zeige POT1 Antikörper) interface.
that the insertion in fingers domain can mediate enzyme processivity and telomerase recruitment to telomeres in a TPP1-dependent manner
these data provide a molecular basis by which POT1 (zeige POT1 Antikörper)-TPP1 increases the processivity of telomerase15. Further, we show that this increased processivity may arise from the dynamic sliding of POT1 (zeige POT1 Antikörper)-TPP1 that induces fast translocation of telomerase.
Mutations have been identified in the TEN-domain of TERT (zeige TERT Antikörper) that disrupt the interaction of telomerase with TPP1 in vivo and in vitro but have very little effect on the catalytic activity of telomerase.

Mouse (Murine) Tripeptidyl Peptidase I (TPP1) Interaktionspartner

telomeres are protected from hyper-resection through the repression of the ATM (zeige ATM Antikörper) and ATR (zeige ATR Antikörper) kinases by TRF2 (zeige TERF2 Antikörper) and TPP1-bound POT1a (zeige POT1 Antikörper)/b, respectively.
Rssults suggested that CLN2, CLN3 (zeige CLN3 Antikörper) and CLN5 (zeige CLN5 Antikörper) genes may play an important role in early embryonal neurogenesis.
demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 (zeige TINF2 Antikörper) phenocopy the POT1a (zeige POT1 Antikörper),b knockout setting without showing additional phenotypes
Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor alpha (zeige PPARA Antikörper) and may have implications in late infantile Batten disease therapy
TPPI activity becomes crucial for the neuronal functions later in development.
Telomere protection by TPP1/POT1 (zeige POT1 Antikörper) requires tethering to TIN2 (zeige TINF2 Antikörper).
TPP1 protects telomere integrity and regulates telomerase recruitment to telomeres, thereby preventing early occurrence of degenerative skin pathologies.
TPP1 deletion resulted in the release of POT1a (zeige POT1 Antikörper) and POT1b from chromatin and loss of these proteins from telomeres, indicating that TPP1 is required for the telomere association of POT1a (zeige POT1 Antikörper) and POT1b but not for their stability.
Lysosomal degradation of cholecystokinin (zeige CCK Antikörper)-(29-33)-amide in mouse brain is dependent on this enzyme: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosis (zeige CLN6 Antikörper) (tripeptidyl peptidase-I)
TPP-I is the predominant proteolytic enzyme responsible for the intracellular degradation of neuromedin B

TPP1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Alternative names and synonyms associated with TPP1

tripeptidyl peptidase I (tpp1) Antikörper
tripeptidyl-peptidase 1 (NAEGRDRAFT_78259) Antikörper
tripeptidyl-peptidase 1 (MCYG_00184) Antikörper
tripeptidyl-peptidase 1 (MGYG_05881) Antikörper
tripeptidyl-peptidase 1 (MGYG_00757) Antikörper
tripeptidyl peptidase 1 (tpp1) Antikörper
tripeptidyl peptidase 1 (TPP1) Antikörper
tripeptidyl peptidase 1 (Tpp1) Antikörper
tripeptidyl peptidase I (Tpp1) Antikörper

Cln2 Antikörper
fa01b09 Antikörper
im:7149243 Antikörper
LPIC Antikörper
TPP-1 Antikörper
TPP-I Antikörper
wu:fa01b09 Antikörper

Bezeichner auf Proteinebene für TPP1

ceroid-lipofuscinosis, neuronal 2 , tripeptidyl-peptidase 1 , cell growth-inhibiting gene 1 protein , growth-inhibiting protein 1 , lysosomal pepstatin insensitive protease , tripeptidyl aminopeptidase , LPIC , TPP-1 , TPP-I , lysosomal pepstatin-insensitive protease , tripeptidyl peptidase 1 , tripeptidyl-peptidase I , tripeptidyl peptidase-I

GENE ID	SPEZIES
798347	Danio rerio
8862382	Naegleria gruberi strain NEG-M
9230210	Arthroderma otae CBS 113480
10026584	Arthroderma gypseum CBS 118893
10031989	Arthroderma gypseum CBS 118893
100195058	Salmo salar
1200	Homo sapiens
485337	Canis lupus familiaris
515575	Bos taurus
83534	Rattus norvegicus
12751	Mus musculus
425576	Gallus gallus
100356773	Oryctolagus cuniculus
100733945	Cavia porcellus
450999	Pan troglodytes
100440001	Pongo abelii

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Show all anti-Tripeptidyl Peptidase I (TPP1) Antikörper with Pubmed References

Human Tripeptidyl Peptidase I (TPP1) Interaktionspartner

Mouse (Murine) Tripeptidyl Peptidase I (TPP1) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with TPP1

Bezeichner auf Proteinebene für TPP1