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anti-Human TCF7 Antikörper:
anti-Mouse (Murine) TCF7 Antikörper:
anti-Rat (Rattus) TCF7 Antikörper:
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Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 (zeige UCHL5 Antikörper) during early vertebrate development by regulating the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway.
Results demonstrated that TCF7 expression is upregulated by LOC728196 which operates as the sponge for miR (zeige MLXIP Antikörper)-513c contributing to glioma cell growth and invasion by modulating.
The results showed SNPs near TCF7 were associated with decreased expression of TCF7 mRNA in PBMCs from patients with SLE and suggested that the mRNA expression of the gene may be correlated with the pathogenesis of SLE.
We demonstrated that the AR-miR-1 (zeige FSD1 Antikörper) axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer.
High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q (zeige MLLT11 Antikörper)/TCF7/CD44 (zeige CD44 Antikörper) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (zeige GIP Antikörper)nsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (zeige CTNNB1 Antikörper) signaling due to the dissociation of beta-catenin (zeige CTNNB1 Antikörper)/TCF-1 (zeige HNF1A Antikörper) complex and the process was orchestrated by STAT-3 (zeige STAT3 Antikörper).
we show that TCF7 is a direct target of miR (zeige MLXIP Antikörper)-34a in prostate cancer that has metastasized to the bone
Naive CD8 (zeige CD8A Antikörper)+ T Cell TCF7 expression is FOXO1 (zeige FOXO1 Antikörper) independent.
the inhibition of beta-catenin's TCF (zeige HNF4A Antikörper)-dependent transcriptional activity, independent of its protein expression level, retains the naive ground state pluripotency in mouse embryonic stem cells.
This is attributed in part to ineffective repression of Tcf1 (zeige HNF1A Antikörper) expression in knockout T cells, as DNMT3a (zeige DNMT3A Antikörper) localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8 (zeige CD8A Antikörper)(+) T cells. These data identify DNMT3a (zeige DNMT3A Antikörper) as a crucial regulator of CD8 (zeige CD8A Antikörper)(+) early effector cell differentiation and effector versus memory fate decisions.
The balance between CD4 (zeige CD4 Antikörper)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 (zeige BCL6 Antikörper) and Tcf7 (encoding TCF-1 (zeige HNF1A Antikörper)) and by the expression of the inhibitory receptors PD-1 (zeige PDCD1 Antikörper) and LAG3 (zeige LAG3 Antikörper).
data reveal that T cell factor 1 (Tcf1) long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8 (zeige CD8A Antikörper)(+) and CD4 (zeige CD4 Antikörper)(+) T cell responses to viral infection
Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (zeige GIP Antikörper) and enhances the magnitude of apoptotic injury.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
The data suggest that miR (zeige MLXIP Antikörper)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (zeige HNF1A Antikörper) expression in osteoblastic cells.
this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage
Our results support a critical role for miR (zeige MLXIP Antikörper)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.
The results indicate that in post-gastrula stage Xenopus embryos, the E-tail of Tcf1 (zeige HNF1A Antikörper) is required for expression of Lef1 (zeige LEF1 Antikörper) and for blood vessel formation.
results indicate that tcf1 (zeige HNF1A Antikörper) acts as an essential activator of foxd3 (zeige FOXD3 Antikörper), which is critical for dorsal mesoderm formation in early embryos
Data indicte that Tcf-1 (zeige HNF1A Antikörper) and Lef-1 (zeige LEF1 Antikörper) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (zeige TCF3 Antikörper) and Tcf--4 (zeige TCF4 Antikörper).
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, T cell factor-1
, T-cell factor 1
, transcription factor 7, T-cell specific
, transcription factor 7 (T-cell specific, HMG-box)
, T-cell factor 7
, T cell-specific transcription factor 1
, transcription factor 7 (T-cell specific, HMG-box) S homeolog
, transcription factor 7 S homeolog