anti-TCF7 (TCF7) Antikörper

Human Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. Postoperative detection of TCF7, c-Myc, and FOSL1 may be useful for stratifying patients with a high risk of unfavorable prognosis, and suppressing TCF7 or its downstream effectors may be a promising strategy for the treatment of Perihilar cholangiocarcinoma (PHCC)

2. The mRNA levels of TCF7 in GC tissues were significantly higher than in corresponding tumor adjacent tissues. The patients of low TCF7 expression and high TCF7 expression accounted for 76.79% (129/168) and 23.21% (39/168), respectively.

3. The expression of LEF1 associated positively with TCF1 (TCF7) and clinical progression of nasopharyngeal carcinoma, predicting poor prognosis.

4. High TCF7 expression associated with poor prognosis in Chinese glioblastoma multiforme patients.

5. sSudy described a TCF7-dependent feedback control of the osteocalcin-GPRC6A axis in brown adipocyte physiologies.

6. Downregulation of lncTCF7 significantly inhibits migration and invasion of CRC cells by inhibiting TCF7 expression, suggesting that lncTCF7 may be a potential target for CRC therapy.

7. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/beta-catenin pathway.

8. Results demonstrated that TCF7 expression is upregulated by LOC728196 which operates as the sponge for miR-513c contributing to glioma cell growth and invasion by modulating.

9. LncRNATCF7 overexpression promoted the proliferation and migration of brain neoplasm glioma cells.

10. The results showed SNPs near TCF7 were associated with decreased expression of TCF7 mRNA in PBMCs from patients with SLE and suggested that the mRNA expression of the gene may be correlated with the pathogenesis of SLE.

11. We demonstrated that the AR-miR-1 axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer.

12. It promotes invasiveness and self-renewal of human non-small cell lung cancer cells. The potential role of lncTCF7 up regulation in NSCLC metastasis and suggest a promising potential to suppress lncTCF7 for NSCLC patients.

13. High expression of TCF7 is associated with osteosarcoma.

14. Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.

15. TCF7 plays critical roles in lung diseases [review]

16. Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury.

17. Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta-catenin/TCF-1 complex and the process was orchestrated by STAT-3.

18. we show that TCF7 is a direct target of miR-34a in prostate cancer that has metastasized to the bone

19. induction of expression activates the Wnt signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation

20. RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis

Mouse (Murine) Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. silencing of Tcf1 by systemic inflammation facilitates effector CD8 T cell differentiation.

2. TCF-1 both enhances HEB protein stability and functionally cooperates with HEB in defining the epigenetic and transcriptional status of CD4(+)CD8(+) thymocytes

3. The requirement of TCF-1 in vivo at stages earlier than double-positive cells to restrain peripheral Th17 immunity by directly binding and inhibiting IL-17 promoter.

4. Study described a TCF7-dependent feedback control of the osteocalcin-GPRC6A axis in brown adipocyte physiologies.

5. Tcf4 and Tcf1 mutants showed severe caudal truncations, as well as duplications of the neural tube

6. Fascin is a novel target of beta-catenin-TCF signaling and is expressed at the invasive front of human colon cancer

7. UCH L1 up-regulates its expression by activation of the oncogenic beta-catenin/TCF signaling

8. beta-catenin/Tcf signaling acts as a switch that determines the outcome of thymic selection downstream the alphabetaTCR cascade

9. Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells

10. the interaction between Hhex and SOX13 may contribute to control Wnt/TCF1 signaling in the early embryo.

11. beta-catenin, Lef1 & Tcf1 are needed for Bmp4 expression maintaining Shh expression in the dental ectoderm. The number of incisors from one placode can be varied through local changes of a mesenchymal signaling circuit involving these proteins.

12. Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis

13. data suggest a model where Notch signals induce TCF-1, and TCF-1 in turn imprints the T-cell fate by upregulating expression of T-cell essential genes

14. Loss of TCF-1 expression impaired the capacity of these innate lymphoid cell subsets to produce IL-5, IL-13, and IL-22 and resulted in crippled responses to intestinal infection with Citrobacter rodentium.

15. IP3R-mediated Ca2+ signaling reinforces Tcf-1 activity to both ensure normal development and to prevent thymocyte neoplasia.

16. TCF-1 physically interacted with Runx3 to cooperatively silence Cd4.

17. This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells. These data identify DNMT3a as a crucial regulator of CD8(+) early effector cell differentiation and effector versus memory fate decisions.

18. critical for suppression of CD8-positive T-cell function

19. this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1, GATA-3 and Runx1) activate Bcl11b for T cell commitment

20. Lef1 and Tcf1 showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members.

Zebrafish Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. C-terminal splice variants of correspond to human B, C, and D isoforms

Xenopus laevis Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. The results indicate that in post-gastrula stage Xenopus embryos, the E-tail of Tcf1 is required for expression of Lef1 and for blood vessel formation.

2. results indicate that tcf1 acts as an essential activator of foxd3, which is critical for dorsal mesoderm formation in early embryos

3. Data indicte that Tcf-1 and Lef-1 exhibit a function in the axis induction assay, which is lacking in Tcf-3 and Tcf--4.