anti-TCF7 (TCF7) Antikörper

Human Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. We demonstrated that the AR-miR-1 (zeige FSD1 Antikörper) axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer.

2. High expression of TCF7 is associated with osteosarcoma.

3. Findings indicate that breast cancer cells with a hyperactive AF1q (zeige MLLT11 Antikörper)/TCF7/CD44 (zeige CD44 Antikörper) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.

4. TCF7 plays critical roles in lung diseases [review]

5. Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (zeige GIP Antikörper)nsiveness to GIP and enhances the magnitude of apoptotic injury.

6. Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (zeige CTNNB1 Antikörper) signaling due to the dissociation of beta-catenin (zeige CTNNB1 Antikörper)/TCF-1 (zeige HNF1A Antikörper) complex and the process was orchestrated by STAT-3 (zeige STAT3 Antikörper).

7. we show that TCF7 is a direct target of miR (zeige MLXIP Antikörper)-34a in prostate cancer that has metastasized to the bone

8. induction of expression activates the Wnt (zeige WNT2 Antikörper) signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation

9. RUNX2 (zeige RUNX2 Antikörper) signaling pathways with their partners TCF7 and FGFR1 (zeige FGFR1 Antikörper)/2 may not be involved in CCD (zeige RUNX2 Antikörper) pathogenesis

10. Results suggest ivermectin as therapeutic WNT protein-TCF (zeige HNF4A Antikörper) transcription factor pathway response blocker to treat WNT (zeige WNT2 Antikörper)-TCF (zeige HNF4A Antikörper)-dependent diseases including multiple cancers.

Mouse (Murine) Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. the inhibition of beta-catenin's TCF (zeige HNF4A Antikörper)-dependent transcriptional activity, independent of its protein expression level, retains the naive ground state pluripotency in mouse embryonic stem cells.

2. This is attributed in part to ineffective repression of Tcf1 (zeige HNF1A Antikörper) expression in knockout T cells, as DNMT3a (zeige DNMT3A Antikörper) localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8 (zeige CD8A Antikörper)(+) T cells. These data identify DNMT3a (zeige DNMT3A Antikörper) as a crucial regulator of CD8 (zeige CD8A Antikörper)(+) early effector cell differentiation and effector versus memory fate decisions.

3. The balance between CD4 (zeige CD4 Antikörper)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 (zeige BCL6 Antikörper) and Tcf7 (encoding TCF-1 (zeige HNF1A Antikörper)) and by the expression of the inhibitory receptors PD-1 (zeige PDCD1 Antikörper) and LAG3 (zeige LAG3 Antikörper).

4. data reveal that T cell factor 1 (Tcf1) long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8 (zeige CD8A Antikörper)(+) and CD4 (zeige CD4 Antikörper)(+) T cell responses to viral infection

5. Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (zeige GIP Antikörper) and enhances the magnitude of apoptotic injury.

6. TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.

7. The data suggest that miR (zeige MLXIP Antikörper)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (zeige HNF1A Antikörper) expression in osteoblastic cells.

8. this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage

9. Our results support a critical role for miR (zeige MLXIP Antikörper)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.

10. TCF-1 (zeige HNF1A Antikörper) was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 (zeige HNF1A Antikörper) promoted Bcl-6 (zeige BCL6 Antikörper) expression but repressed Blimp1 (zeige PRDM1 Antikörper) expression.

Zebrafish Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

Xenopus laevis Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. The results indicate that in post-gastrula stage Xenopus embryos, the E-tail of Tcf1 (zeige HNF1A Antikörper) is required for expression of Lef1 (zeige LEF1 Antikörper) and for blood vessel formation.

2. results indicate that tcf1 (zeige HNF1A Antikörper) acts as an essential activator of foxd3 (zeige FOXD3 Antikörper), which is critical for dorsal mesoderm formation in early embryos

3. Data indicte that Tcf-1 (zeige HNF1A Antikörper) and Lef-1 (zeige LEF1 Antikörper) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (zeige TCF3 Antikörper) and Tcf--4 (zeige TCF4 Antikörper).