anti-TCF7 (TCF7) Antikörper

Human Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/beta-catenin pathway.

2. Results demonstrated that TCF7 expression is upregulated by LOC728196 which operates as the sponge for miR-513c contributing to glioma cell growth and invasion by modulating.

3. LncRNATCF7 overexpression promoted the proliferation and migration of brain neoplasm glioma cells.

4. The results showed SNPs near TCF7 were associated with decreased expression of TCF7 mRNA in PBMCs from patients with SLE and suggested that the mRNA expression of the gene may be correlated with the pathogenesis of SLE.

5. We demonstrated that the AR-miR-1 axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer.

6. It promotes invasiveness and self-renewal of human non-small cell lung cancer cells. The potential role of lncTCF7 up regulation in NSCLC metastasis and suggest a promising potential to suppress lncTCF7 for NSCLC patients.

7. High expression of TCF7 is associated with osteosarcoma.

8. Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.

9. TCF7 plays critical roles in lung diseases [review]

10. Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury.

11. Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta-catenin/TCF-1 complex and the process was orchestrated by STAT-3.

12. we show that TCF7 is a direct target of miR-34a in prostate cancer that has metastasized to the bone

13. induction of expression activates the Wnt signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation

14. RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis

15. Results suggest ivermectin as therapeutic WNT protein-TCF transcription factor pathway response blocker to treat WNT-TCF-dependent diseases including multiple cancers.

16. miRNAs inhibited the expression of the luciferase reporter constructs containing 3'UTRs of these genes and downregulated protein expression of TERT and the TCF7 transcription factor, which mediates the canonical Wnt pathway.

17. we establish that ATF2 family members physically and functionally interact with TCF1/LEF1 factors to promote target gene expression and hematopoietic tumor cell growth

18. Studied the expression of TCF/LEF and SFRP family members (SFRP1 and SFRP3) to gain a better understanding of biological signaling pathways responsible for epidemiology and clinical parameters of clear cell RCC (cRCC).

19. in this review, we will focus on the function of beta-catenin/TCF-1 pathway in the regulation of thymic and peripheral T cell differentiation processes--{REVIEW}

20. The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin.

Mouse (Murine) Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. Naive CD8+ T Cell TCF7 expression is FOXO1 independent.

2. the inhibition of beta-catenin's TCF-dependent transcriptional activity, independent of its protein expression level, retains the naive ground state pluripotency in mouse embryonic stem cells.

3. This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells. These data identify DNMT3a as a crucial regulator of CD8(+) early effector cell differentiation and effector versus memory fate decisions.

4. The balance between CD4(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (encoding TCF-1) and by the expression of the inhibitory receptors PD-1 and LAG3.

5. data reveal that T cell factor 1 (Tcf1) long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8(+) and CD4(+) T cell responses to viral infection

6. Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury.

7. TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.

8. The data suggest that miR-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 expression in osteoblastic cells.

9. this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage

10. Our results support a critical role for miR-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.

11. TCF-1 was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 promoted Bcl-6 expression but repressed Blimp1 expression.

12. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking.

13. Our data support that the loss of Tcf7 diminishes hematopoietic stem cell function.

14. TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes.

15. These results are reminiscent of the critical roles of TCF-1 in early T cell development.

16. The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin.

17. TCF-1-deficient (Tcf7(-/-)) mice developed aggressive T cell malignancy.

18. TCF-1 and lymphoid enhancer-binding factor (LEF)-1 are essential for generation of memory precursors and functional memory CD8+ T cells.

19. Together with RUNX1, TCF7 regulates a network of transcription factors that characterize the CD34+ cell state.

20. TCF1 and beta-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus.

Zebrafish Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. C-terminal splice variants of correspond to human B, C, and D isoforms

Xenopus laevis Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) Interaktionspartner

1. The results indicate that in post-gastrula stage Xenopus embryos, the E-tail of Tcf1 is required for expression of Lef1 and for blood vessel formation.

2. results indicate that tcf1 acts as an essential activator of foxd3, which is critical for dorsal mesoderm formation in early embryos

3. Data indicte that Tcf-1 and Lef-1 exhibit a function in the axis induction assay, which is lacking in Tcf-3 and Tcf--4.