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anti-Human PKC alpha Antikörper:
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Cow (Bovine) Monoclonal PKC alpha Primary Antibody für ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. in Neuron 1999
Show all 14 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody für ICS - ABIN1176927
Zhang, Bontrager, Hemler: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. in The Journal of biological chemistry 2001
Show all 4 Pubmed References
Human Polyclonal PKC alpha Primary Antibody für WB - ABIN3043549
Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. in Japanese journal of clinical oncology 2015
Show all 2 Pubmed References
Human Polyclonal PKC alpha Primary Antibody für IHC (p), WB - ABIN3043025
Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. in International immunopharmacology 2015
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Human Polyclonal PKC alpha Primary Antibody für IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Mammalian Monoclonal PKC alpha Primary Antibody für IHC (fro), WB - ABIN2476256
Donovan, Lansu, Williams, Denning, Gentile: Long QT2 mutation on the Kv11.1 ion channel inhibits current activity by ablating a protein kinase C? consensus site. in Molecular pharmacology 2012
Human Monoclonal PKC alpha Primary Antibody für ICS - ABIN1177144
Newton: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. in The Biochemical journal 2003
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (zeige CDK2 Antikörper), leading to shortening of G1 and S phases
Neural induction by Syn4 (zeige SNTG1 Antikörper) through the PKC (zeige PKC Antikörper) pathway requires inhibition of PKCdelta (zeige PKCd Antikörper) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (zeige PKC Antikörper) of the KCNE1 (zeige KCNE1 Antikörper) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (zeige PKC Antikörper) in Kv4.3 (zeige KCND3 Antikörper)
Data show that PKC (zeige PKC Antikörper) staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2 (zeige PCP2 Antikörper).
A characteristic di-leucine motif (SVRPLL) in the C-terminal cytoplasmic region of ATP11C becomes functional upon PKCalpha activation. Moreover, endocytosis of ATP11C is induced by Ca(2 (zeige CA2 Antikörper)+)-signaling via Gq-coupled receptors.
The haplotype carrying rs9909004 influences PRKCA expression in the heart and is associated with traits linked to heart failure, potentially affecting therapy of heart failure
our results demonstrate that Pc-induced expression of HO-1 (zeige HMOX1 Antikörper) is mediated by the PKCA-Nrf-2 (zeige GABPA Antikörper)/HO-1 (zeige HMOX1 Antikörper) pathway, and inhibits UVB-induced apoptotic cell death in primary skin cells.
Regulation of vascular smooth muscle cell calcification by syndecan-4 (zeige SDC4 Antikörper)/FGF-2 (zeige FGF2 Antikörper)/PKCalpha signalling and cross-talk with TGF-beta1 (zeige TGFB1 Antikörper).
this study reveals a protective role for miR (zeige MLXIP Antikörper)-706 by blocking the oxidative stress-induced (zeige SQSTM1 Antikörper) activation of PKCalpha/TAOK1 (zeige TAOK1 Antikörper). Our results further identify a major implication for miR (zeige MLXIP Antikörper)-706 in preventing hepatic fibrogenesis and suggest that miR (zeige MLXIP Antikörper)-706 may be a suitable molecular target for anti-fibrosis therapy.
We also discuss the contribution of PKC (zeige PRRT2 Antikörper) enzymes to pancreatic diseases, including insulin (zeige INS Antikörper) resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer
data provided evidence that increased Rack1 (zeige GNB2L1 Antikörper)-mediated upregulation of PKC (zeige PRRT2 Antikörper) kinase activity may be responsible for the development of chemoresistance in T-ALL-derived cell line potentially by reducing FEM1b (zeige FEM1B Antikörper) and Apaf-1 (zeige APAF1 Antikörper) level.
Regulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells has been summarized. (Review)
these data propose a mechanism where CD82 (zeige CD82 Antikörper) membrane organization regulates sustained PKCalpha signaling that results in an aggressive leukemia phenotype. These observations suggest that the CD82 (zeige CD82 Antikörper) scaffold may be a potential therapeutic target for attenuating aberrant signal transduction in acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)).
MiR (zeige MLXIP Antikörper)-3148 may play an important role in the development of CTEPH. The key mechanisms for this miRNA may be hsa (zeige CD24 Antikörper)-miR (zeige MLXIP Antikörper)-3148-AR-pathways in cancer or hsa (zeige CD24 Antikörper)-miR (zeige MLXIP Antikörper)-3148-PRKCA-pathways in cancer/glioma/ErbB (zeige EGFR Antikörper) signaling pathway.
This indicates a role for PKC (zeige PKC Antikörper) in dynamically controlling the trafficking of SNAT3 (zeige SLC38A3 Antikörper) transporters in astrocytes in situ.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC (zeige PLC Antikörper)) and protein kinase C (PKC (zeige PKC Antikörper)).
LAV-BPIFB4 (zeige BPIFB4 Antikörper) isoform modulates eNOS (zeige NOS3 Antikörper) signalling through Ca2 (zeige CA2 Antikörper)+/PKC-alpha-dependent mechanism.
However, the mechanism that induces release of IL-6 (zeige IL6 Antikörper) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (zeige IL6 Antikörper) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC (zeige PKC Antikörper), and cAMP response element-binding protein signal transduction pathway.
protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 (zeige MAPK7 Antikörper) MAP kinase (zeige MAPK1 Antikörper) is activated in response to PDGF (zeige PDGFA Antikörper)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (zeige MAP3K2 Antikörper), Mek1 (zeige MAP2K1 Antikörper)/2, Mek5 (zeige MAP2K5 Antikörper), PI3-kinase (zeige PIK3CA Antikörper) and protein kinase C (PKC (zeige PKC Antikörper)).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (zeige SYT1 Antikörper) phosphorylation is an essential step in PKC (zeige PKC Antikörper)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (zeige PKC Antikörper) substrates, Munc13-1 (zeige UNC13A Antikörper) and Munc18-1 (zeige STXBP1 Antikörper).
PKC (zeige PKC Antikörper) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (zeige GRM5 Antikörper) and AMPA (zeige GRIA3 Antikörper)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (zeige CA2 Antikörper)+-sensitivity, structure and kinetics are brought about through PKC (zeige PKC Antikörper) phosphorylation of cardiac troponin T (zeige TNNT2 Antikörper).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Antikörper) expression by NF-kappaB (zeige NFKB1 Antikörper)-MT1-MMP (zeige MMP14 Antikörper)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (zeige ASS1 Antikörper) Ser (zeige SIGLEC1 Antikörper)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (zeige TUBB Antikörper).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (zeige Akap6 Antikörper)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper)
By regulating VEGFR2 (zeige KDR Antikörper) expression and activation, PKC-epsilon (zeige PRKCE Antikörper) expression is critical for activation of Akt (zeige AKT1 Antikörper) and eNOS (zeige NOS3 Antikörper) by VEGF (zeige VEGFA Antikörper) and contributes to VEGF (zeige VEGFA Antikörper)-stimulated Erk (zeige MAPK1 Antikörper) activation, whereas PKC-alpha has opposite effects.
High PKC alpha expression is associated with retinal neovascularization.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (zeige CA2 Antikörper)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (zeige PPP1R14A Antikörper) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (zeige ESR1 Antikörper).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha