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anti-Human PKC alpha Antikörper:
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Cow (Bovine) Monoclonal PKC alpha Primary Antibody für ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. in Neuron 1999
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Chicken Monoclonal PKC alpha Primary Antibody für IF, IP - ABIN967750
Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. in The Journal of comparative neurology 2008
Show all 6 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody für IF, IP - ABIN967751
Nishizuka: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. in Nature 1988
Show all 5 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody für ICS - ABIN1176927
Zhang, Bontrager, Hemler: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. in The Journal of biological chemistry 2001
Show all 4 Pubmed References
Human Polyclonal PKC alpha Primary Antibody für WB - ABIN3043549
Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. in Japanese journal of clinical oncology 2015
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Human Polyclonal PKC alpha Primary Antibody für IHC (p), WB - ABIN3043025
Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. in International immunopharmacology 2015
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Human Polyclonal PKC alpha Primary Antibody für IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Human Monoclonal PKC alpha Primary Antibody für ICS - ABIN1177145
Newton: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. in The Biochemical journal 2003
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (zeige CDK2 Antikörper), leading to shortening of G1 and S phases
Neural induction by Syn4 (zeige SNTG1 Antikörper) through the PKC (zeige PKC Antikörper) pathway requires inhibition of PKCdelta (zeige PKCd Antikörper) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (zeige PKC Antikörper) of the KCNE1 (zeige KCNE1 Antikörper) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (zeige PKC Antikörper) in Kv4.3 (zeige KCND3 Antikörper)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
high expression of both PLCE1 (zeige PLCE1 Antikörper) and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers.
In nasopharyngeal carcinoma, PKCalpha is linked to the invasion of adjacent tissues, especially in the skull base. Down-regulation of PKCalpha is a risk factor for regional lymph node metastasis.
LAV-BPIFB4 (zeige BPIFB4 Antikörper) isoform modulates eNOS (zeige NOS3 Antikörper) signalling through Ca2 (zeige CA2 Antikörper)+/PKC-alpha-dependent mechanism.
Studied interactions between protein kinase C alpha (PKCalpha), FOXC2 (zeige FOXC2 Antikörper), and p120-catenin (CTNND1 (zeige CTNND1 Antikörper)) in breast cancer, cell migration/ invasion; found PKCalpha acts as an upstream regulator of FOXC2 (zeige FOXC2 Antikörper), which in turn represses the expression of p120-catenin (zeige CTNND1 Antikörper), in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer
Phosphorylated PKCalpha is elevated in epidermis genetically deleted of DLX3 (zeige DLX3 Antikörper) and the hyperproliferative response to TPA (zeige PLAT Antikörper) is increased, suggesting that the homeobox protein indirectly regulates the activity in the pathway, possibly through an effect on reduced phosphatase expression
Results show that PKCalpha expression is under the regulation of miR (zeige MLXIP Antikörper)-142-3p contributing to reduced osteoclasts survival.
Molecular Determinants for the Binding Mode of Alkylphosphocholines in the C2 Domain of PKCalpha.
Studies suggest that rare deleterious variants of PARD3 (zeige PARD3 Antikörper) in the aPKC-binding region contribute to human cranial neural tube defect (NTD).
study identified PKCalpha as hepatitis E virus HEV in host defense
ADP inhibits mesothelioma cell proliferation via PKC-alpha/ERK (zeige EPHB2 Antikörper)/p53 (zeige TP53 Antikörper) signaling.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC (zeige PLC Antikörper)) and protein kinase C (PKC (zeige PKC Antikörper)).
However, the mechanism that induces release of IL-6 (zeige IL6 Antikörper) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (zeige IL6 Antikörper) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC (zeige PKC Antikörper), and cAMP response element-binding protein signal transduction pathway.
protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 (zeige MAPK7 Antikörper) MAP kinase (zeige MAPK1 Antikörper) is activated in response to PDGF (zeige PDGFA Antikörper)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (zeige MAP3K2 Antikörper), Mek1 (zeige MAP2K1 Antikörper)/2, Mek5 (zeige MAP2K5 Antikörper), PI3-kinase (zeige PIK3CA Antikörper) and protein kinase C (PKC (zeige PKC Antikörper)).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (zeige SYT1 Antikörper) phosphorylation is an essential step in PKC (zeige PKC Antikörper)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (zeige PKC Antikörper) substrates, Munc13-1 (zeige UNC13A Antikörper) and Munc18-1 (zeige STXBP1 Antikörper).
These data indicate that LPA increases CCN2 (zeige CTGF Antikörper) expression through the activation of PKC (zeige PKC Antikörper) and PKA. Thus, the regulatory functions of the PKC (zeige PKC Antikörper) and PKA pathways are implicated in the LPA-induced increase in CCN2 (zeige CTGF Antikörper) expression
PKC (zeige PKC Antikörper) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (zeige GRM5 Antikörper) and AMPA (zeige GRIA3 Antikörper)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (zeige CA2 Antikörper)+-sensitivity, structure and kinetics are brought about through PKC (zeige PKC Antikörper) phosphorylation of cardiac troponin T (zeige TNNT2 Antikörper).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Antikörper) expression by NF-kappaB (zeige NFKB1 Antikörper)-MT1-MMP (zeige MMP14 Antikörper)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (zeige ASS1 Antikörper) Ser (zeige SIGLEC1 Antikörper)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (zeige TUBB Antikörper).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (zeige Akap6 Antikörper)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper)
By regulating VEGFR2 (zeige KDR Antikörper) expression and activation, PKC-epsilon (zeige PRKCE Antikörper) expression is critical for activation of Akt (zeige AKT1 Antikörper) and eNOS (zeige NOS3 Antikörper) by VEGF (zeige VEGFA Antikörper) and contributes to VEGF (zeige VEGFA Antikörper)-stimulated Erk (zeige MAPK1 Antikörper) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (zeige CA2 Antikörper)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (zeige PPP1R14A Antikörper) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (zeige ESR1 Antikörper).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha