anti-Sphingosine Kinase 1 (SPHK1) Antikörper

Bezeichnung:: anti-Sphingosine Kinase 1 Antikörper (SPHK1)

Auf www.antikoerper-online.de finden Sie aktuell 202 Sphingosine Kinase 1 (SPHK1) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Sphingosine Kinase 1 Proteine (14) und Sphingosine Kinase 1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 248 Sphingosine Kinase 1 Produkte verfügbar.

Synonyme:: 1110006G24Rik, CG1747, Dmel\\CG1747, F18E5.160, F18E5_160, Sk1, sphingosine kinase 1, SPHK, SPHK1, Spk1

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	SPHK1	8877	Q9NYA1
	SPHK1	20698	Q8CI15
	SPHK1	170897	Q91V26
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Verknüpfte Pathways mit anti-Sphingosine Kinase 1 Antikörper

VEGF Signaling

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Am meisten referenzierte anti-Sphingosine Kinase 1 Antikörper

Human Polyclonal SPHK1 Primary Antibody für IHC (p), WB - ABIN391346 : Nayak, Huo, Kwang, Pushparaj, Kumar, Ling, Dheen: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. in Neuroscience 2010 (PubMed)
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Human Monoclonal SPHK1 Primary Antibody für ELISA, WB - ABIN522355 : Billich, Urtz, Reuschel, Baumruker: Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells. in The international journal of biochemistry & cell biology 2009 (PubMed)
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Human Polyclonal SPHK1 Primary Antibody für IF (p), IHC (p) - ABIN748598 : Tani, Tabuchi, Hara: Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea. in Neurotoxicity research 2016 (PubMed)
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Human Polyclonal SPHK1 Primary Antibody für ELISA, WB - ABIN314839 : Igarashi, Okada, Hayashi, Fujita, Jahangeer, Nakamura: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. in The Journal of biological chemistry 2003 (PubMed)
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Human Polyclonal SPHK1 Primary Antibody für WB - ABIN391345 : Hayashi, Nakagami, Takami, Koriyama, Mori, Tamai, Sun, Nagao, Morishita, Kaneda: FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. in Arteriosclerosis, thrombosis, and vascular biology 2009 (PubMed)
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Human Polyclonal SPHK1 Primary Antibody für WB - ABIN391347 : Di, Kawamura, Gao, Tang, Berdyshev, Vogel, Zhao, Sharma, Bachmaier, Xu, Malik: A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. in The Journal of biological chemistry 2010 (PubMed)
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Human Polyclonal SPHK1 Primary Antibody für IHC (p) - ABIN4355657 : Ruckhäberle, Karn, Denkert, Loibl, Ataseven, Reimer, Becker, Holtrich, Rody, Darb-Esfahani, Nekljudova, von Minckwitz: Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer. in Journal of cancer research and clinical oncology 2013 (PubMed)
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Human Polyclonal SPHK1 Primary Antibody für ELISA, WB - ABIN257695 : Kohama, Olivera, Edsall, Nagiec, Dickson, Spiegel: Molecular cloning and functional characterization of murine sphingosine kinase. in The Journal of biological chemistry 1998 (PubMed)
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Human Polyclonal SPHK1 Primary Antibody für IHC (p) - ABIN2476568 : Sadler: Inhibitors of phosphodiesterase III block stimulation of Xenopus laevis oocyte ribosomal S6 kinase activity by insulin-like growth factor-I. in Molecular endocrinology (Baltimore, Md.) 1992 (PubMed)
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Cow (Bovine) Polyclonal SPHK1 Primary Antibody für EIA, WB - ABIN4620336 : Zhang, Chung, Oldenburg: A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. in Journal of biomolecular screening 2000 (PubMed)
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Weitere Antikörper gegen Sphingosine Kinase 1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) Interaktionspartner

Sk1 and Sk2 (zeige KCNN2 Antikörper) are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) Interaktionspartner

findings indicate a role of SPHK1 in modulating FB1 (zeige TFPT Antikörper)-triggered cell death via SA and JA pathway interactions.
SPHK/phyto-S1P (zeige MBTPS1 Antikörper) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Rabbit Sphingosine Kinase 1 (SPHK1) Interaktionspartner

Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (zeige MBTPS1 Antikörper) system activates in parallel to viral replication and the inflammatory process induced by the virus.

Human Sphingosine Kinase 1 (SPHK1) Interaktionspartner

Data show that sphingosine kinase 1 (SPHK1) was significantly upregulated in oral squamous cell carcinoma (OSCC) tissues and low levels of sphingosine-1-phosphate lyase 1 (SGPL1 (zeige SGPL1 Antikörper)) mRNA correlated with a worse overall survival, and that sphingosine-1-phosphate receptor 2 (S1PR2 (zeige S1PR2 Antikörper)) is over-expressed in a subset of tumours, which in part mediates sphingosine 1-phosphate (S1P (zeige MBTPS1 Antikörper))-induced migration of OSCC cells.
SphK1 expression regulates the early stage of colon carcinogenesis and tumor growth, thus inhibition of SphK1 may be an effective strategy for colon cancer chemoprevention.
the blockage of SPHK1 activity to attenuate autophagy may be a promising strategy for the prevention and treatment of patocellular carcinoma
Results indicate the involvement of sphingosine kinase-1 (SphK1) in the invasiveness of oral squamous cell carcinoma (OSCC) and in unfavorable prognosis.
Sphk1 induced NF-kappaB (zeige NFKB1 Antikörper)-p65 (zeige GORASP1 Antikörper) activation, increased expression of cyclin D1 (zeige CCND1 Antikörper), shortened the cell division cycle, and thus promoted proliferation of breast epithelial cells.
Inhibiting SPHK1 using specific siRNAs or the pharmacological inhibitor FTY720 led to potent anti-cancer activity in nasopharyngeal carcinoma cells/
Everolimus sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1alpha (zeige HIF1A Antikörper) and sphingosine kinase 1 expression.
Sphingosine kinase-1 (SK1) plays a crucial role in the metabolic reprogramming of human ovarian cancer cells.
The combination of FTY720 with the SPHK1 inhibitor SKI (zeige SKI Antikörper)-II results in synergistic inhibition of MM growth. CXCR4 (zeige CXCR4 Antikörper)/CXCL12 (zeige CXCL12 Antikörper)-enhanced expression correlates with reduced MM cell sensitivity to both FTY720 and SKI (zeige SKI Antikörper)-II inhibitors, and with SPHK1 coexpression in both cell lines and primary MM bone marrow (BM) samples, suggesting regulative cross-talk between the CXCR4 (zeige CXCR4 Antikörper)/CXCL12 (zeige CXCL12 Antikörper) and SPHK1 pathways in MM cells
SphK1 is involved in maladaptive hypertrophy and we propose that heart failure might be an additional direct target for therapeutic intervention with SphK1 inhibitors.

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) Interaktionspartner

SphK1 expression regulates the early stage of colon carcinogenesis and tumor growth, thus inhibition of SphK1 may be an effective strategy for colon cancer chemoprevention.
Studied role of microglial cells in inflammation via a Toll-like receptor 2 (TLR2)-->sphingosine kinase 1 (Sphk1)-->pro-inflammatory cytokine pathway in cerebral ischemia/reperfusion (I/R).
SphK1 is involved in maladaptive hypertrophy and we propose that heart failure might be an additional direct target for therapeutic intervention with SphK1 inhibitors.
These results suggest that SphK1 expression plays a pivotal role in the early stages of colon carcinogenesis
the recruitment of Sphk1 to sphingosine-enriched endocytic vesicles and the generation of sphingosine-1-phosphate facilitate membrane trafficking along the endosomal pathway.
SK1 activation is renoprotective via induction of autophagy in the fibrotic process
donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.
Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.
These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (zeige S1PR1 Antikörper) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

Sphingosine Kinase 1 (SPHK1) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Sphingosine Kinase 1 (SPHK1)

Sphingosine kinase 1 (Sk1) Antikörper
sphingosine kinase 1 (SPHK1) Antikörper
sphingosine kinase 1 L homeolog (sphk1.L) Antikörper
sphingosine kinase 1 (Sphk1) Antikörper

1110006G24Rik Antikörper
CG1747 Antikörper
Dmel\\CG1747 Antikörper
F18E5.160 Antikörper
F18E5_160 Antikörper
Sk1 Antikörper
sphingosine kinase 1 Antikörper
SPHK Antikörper
SPHK1 Antikörper
Spk1 Antikörper

Bezeichner auf Proteinebene für SPHK1

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID	SPEZIES
32089	Drosophila melanogaster
427803	Gallus gallus
495437	Xenopus laevis
738821	Pan troglodytes
828239	Arabidopsis thaliana
100058875	Equus caballus
100357790	Oryctolagus cuniculus
8877	Homo sapiens
20698	Mus musculus
618605	Bos taurus
170897	Rattus norvegicus
483329	Canis lupus familiaris

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Show all anti-Sphingosine Kinase 1 (SPHK1) Antikörper with Pubmed References