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High MST2 expression is associated with malignant melanoma.
Here, the authors discover SAV1 (zeige SAV1 Proteine)-mediated inhibition of the PP2A (zeige PPP2R4 Proteine) complex STRIPAK(SLMAP (zeige SLMAP Proteine)) as a key mechanism of MST1 (zeige MST1 Proteine)/2 activation.
Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A (zeige MOBKL1B Proteine) regulates its interaction with both MST (zeige MAP3K10 Proteine) kinases and LATS/NDR (zeige STK38 Proteine) family kinases in vitro.
In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (zeige MST1 Proteine)/2)/YAP (zeige YAP1 Proteine) signaling, and that inhibition of miR (zeige MLXIP Proteine)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (zeige SOX2 Proteine) and SALL4 (zeige SALL4 Proteine).
These findings reveal a novel layer of regulation for MST2 in mitosis and its role in tumorigenesis.
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1 (zeige MST1 Proteine)/2 protein kinases) - Yes associated protein 1 (YAP (zeige YAP1 Proteine)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
H-ras (zeige HRAS Proteine), via an Erk (zeige EPHB2 Proteine)-dependent mechanism, downregulates Mst1 (zeige MST1 Proteine)/Mst2 activity by inducing the formation of inactive Mst1 (zeige MST1 Proteine)/Mst2 heterodimers.
Results show that STK3 is targeted by Casp6 (zeige CASP6 Proteine) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (zeige CASP3 Proteine)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.
It is involved in apoptosis and serine/threonine kinase 3 (STK3 (zeige PKN1 Proteine)) is a recently identified caspase-6 (zeige CASP6 Proteine) substrate.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (zeige MST1 Proteine) and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (zeige YAP1 Proteine) target genes and hepatocyte proliferation.
Studies indicate that Hippo (Hpo (zeige GFER Proteine); MST1 (zeige MST1 Proteine)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (zeige NFKB1 Proteine) pathway
the TLR-Mst1 (zeige MST1 Proteine)-Mst2-Rac (zeige AKT1 Proteine) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (zeige STK4 Proteine) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (zeige MAP1LC3A Proteine) by the STK3 (zeige PKN1 Proteine) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (zeige MST1 Proteine), as a critical regulator of caspase (zeige CASP3 Proteine)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
Mst1 (zeige MST1 Proteine)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (zeige MST1 Proteine)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)