NFKB2 ELISA Kits
12 Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) ELISA Kits von 6 Herstellern verfügbar auf www.antikoerper-online.de.
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NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 FLISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) FLISA Kit
NFKB2 FLISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) FLISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 ELISA Kit (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2) ELISA Kit
NFKB2 Antigen-Profil
Protein Überblick
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14- activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form\; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity).
Alternative names and synonyms associated with NFKB2
- nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 (Nfkb2) Antikörper
- lyt Antikörper
- NF-kappaB2 Antikörper
- p49 Antikörper
- p49/p100 Antikörper
- p50B Antikörper
- p52 Antikörper
Bezeichner auf Proteinebene für NFKB2
DNA-binding factor KBF2 , NF kappaB2 , nuclear factor NF-kappa-B p100 subunit , nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
GENE ID | SPEZIES |
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18034 | Mus musculus |