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anti-Human TLR9 Antikörper:
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Dog (Canine) Monoclonal TLR9 Primary Antibody für CyTOF, ELISA - ABIN4360430
Gantner, Hermann, Nakashima, Matsukawa, Sakai, Bacon: CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides. in European journal of immunology 2003
Show all 126 Pubmed References
Dog (Canine) Monoclonal TLR9 Primary Antibody für FACS, ICC - ABIN4360434
Dillmann, Ringel, Ringleb, Mora, Olesch, Fink, Roberts, Brüne, Weigert: S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. in Journal of immunology (Baltimore, Md. : 1950) 2016
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Dog (Canine) Monoclonal TLR9 Primary Antibody für CyTOF, ELISA - ABIN4360432
Damiano, Caputo, Bianco, DArmiento, Leonardi, De Placido, Bianco, Agrawal, Ciardiello, Tortora: Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
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Dog (Canine) Monoclonal TLR9 Primary Antibody für ELISA - ABIN4360433
Abel, Wang, Fritts, Sanchez, Chung, Fitzgerald-Bocarsly, Krieg, Miller et al.: Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon ... in Clinical and diagnostic laboratory immunology 2005
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Human Monoclonal TLR9 Primary Antibody für FACS, IF - ABIN2191964
Ahmad-Nejad, Häcker, Rutz, Bauer, Vabulas, Wagner: Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. in European journal of immunology 2002
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Human Monoclonal TLR9 Primary Antibody für FACS, IF - ABIN2191962
Rumio, Besusso, Palazzo, Selleri, Sfondrini, Dubini, Ménard, Balsari: Degranulation of paneth cells via toll-like receptor 9. in The American journal of pathology 2004
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Human Monoclonal TLR9 Primary Antibody für FACS, IF - ABIN2191963
Rutz, Metzger, Gellert, Luppa, Lipford, Wagner, Bauer: Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. in European journal of immunology 2004
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Human Monoclonal TLR9 Primary Antibody für FACS, IHC (fro) - ABIN531988
Wong, Cheung, Ip, Lam: Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. in American journal of respiratory cell and molecular biology 2007
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Mouse (Murine) Polyclonal TLR9 Primary Antibody für IHC - ABIN967190
Hemmi, Takeuchi, Kawai, Kaisho, Sato, Sanjo, Matsumoto, Hoshino, Wagner, Takeda, Akira: A Toll-like receptor recognizes bacterial DNA. in Nature 2000
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Mouse (Murine) Polyclonal TLR9 Primary Antibody für IHC - ABIN967189
Bauer, Kirschning, Häcker, Redecke, Hausmann, Akira, Wagner, Lipford: Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. in Proceedings of the National Academy of Sciences of the United States of America 2001
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present study results demonstrate no involvement of TLR9 C296T/ Pro99Leu polymorphism in cervical cancer susceptibility and supports worldwide minor allele frequency (MAF) (0.0002) status of the same as no nucleotide variation was detected in any of the study participants
Modulation of TLR9 signaling pathways and decrease of macrophage-mediated inflammation might be potential therapeutic strategies in LMNA-RM management.
This study characterizes a strategy to apply localized TLR9 stimulation to a tumor type not accessible for direct injection, a strategy that may expand the therapeutic potential of PD-1 blockade in non-small cell lung cancer
Protein concentration of TLR-9 was significantly higher in tumors of gastro-esophageal junction cancer with lymph node metastasis and depth of tumor invasion.
TLR9 binding site exhibits a strong bias in favor of a phosphodiester backbone over the phosphorothioate backbone of the CpG motif. Furthermore, while single point mutations of W47, W96 and K690 within the TLR9 binding site retains full TLR9 activation by phosphodiester-based oligodeoxynucleotides, activation by phosphorothioate-based oligodeoxynucleotides is strongly impaired.
TLR9 expression and function were significantly suppressed in a cohort of chronic hepatitis B virus carriers
Mitochondrial DNA contains CpG motifs that incite proinflammatory signaling through the endosomal, nucleotide-sensing Toll-like receptor, TLR9.
Our results demonstrate a defect of the TLR9 responses in IgA deficiency that leads to B cell dysregulation and decreased IgA production.
Study of TLR3 rs3775290, TLR7 rs17900 and TLR9 rs352140 SNPs in chronic hepatitis C (HCV) Egyptian patient cohort revealed that only heterozygous CT genotype of TLR3 rs3775290 may be a susceptibility risk factor for chronic HCV infection and the homozygous CC and the combined CC-AT-GA female genotypes may be protective.
these results show a direct engagement of TLR9 ligand in T helper cells
TLR9 polymorphisms were screened in 131 chronic hepatitis B patient and 168 individuals by polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) technique
Results of a study compared Spanish psoriasis patient and healthy controls showed significant associations between functional TLR3, TLR7 and TLR9 single nucleotide polymorphisms and psoriatic arthritis, earlier disease onset and a greater risk for psoriasis.
infection with dengue virus (DENV), an RNA virus, activates TLR9 in human dendritic cells (DCs).
Intracellular IFN-gamma production upon stimulation with TLR2 and TLR9 ligands.
The ability to form complexes with DNA and to subsequently activate TLR9 is thought to be related to the cationicity of the peptides and to secondary structure, because a predominant alpha-helical structure was shown to stabilize the peptide-DNA interaction
TLR9 signaling might enhance antibody titers at the expense of the ability of B cells to engage in germinal-center events that are highly dependent on B cells' capture and presentation of antigen
TLR9 1635AA genotype is associated with lower CD4 counts in HIV positive patients.TLR9 1635AA polymorphism correlates with higher plasma IP10 levels in HIV infected patients.
the authors provide an overview on the contribution of TLR7 and TLR9 to autoimmune diseases and discuss recent findings indicating a pivotal role for these two receptors, along with Epstein-Barr virus, in driving, perpetuating, and/or amplifying intrathymic B cell dysregulation and autoimmune responses in myasthenia gravis.
the polymorphisms in TLR7 and TLR9 are associated with asthma-related phenotypes and asthma risk in the study population.
Results show that cell-free DNA (cfDNA) could promote colorectal cancer cell proliferation via Toll-like receptor 9 (TLR9) and induced robust release of chemokine interleukin 8 (IL-8; CXCL8 Chemokine).
A toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury.
Data show that toll-like receptor 9 (TLR9) signaling by CpG, while promoting vigorous proliferation, completely fails to induce differentiation of toll-like receptor 9 (FO B) cells into plasmablasts and plasma cells (PBs/PCs).
A critical role of CD180 in regulating TLR7- and TLR9-mediated activation of macrophages and DCs.
model of systemic autoimmunity that depends on T cell detection of a membrane-bound OVA fusion protein expressed by MHC class II+ cells, expression of TLR7, expression of the type I IFN receptor, and loss of expression of TLR9, with a high frequency of OVA-specific Tbet+, IFN-gamma+, and FasL-expressing Th1 cells as well as autoantibody-producing B cells
Data suggest a direct link between microtubule-associated protein 1-light chain 3 (LC3)-associated phagocytosis (LAP) formation and IKK alpha (IKKalpha) recruitment downstream of -like receptor 9 (TLR9) activation that is necessary to facilitate type I IFN production.
data extend previous studies, demonstrating that rfd phages induce Ag-specific IgG and CD8(+) T cell-mediated responses and confer protection against an important human parasite infection, through a TLR9-dependent mechanism.
TLR7 and TLR9 specify monocyte fate and identify a specialized population of phagocytes responsible for anemia and thrombocytopenia associated with inflammation and infection.
this study shows that TLR9 promotes mobilization of pulmonary dendritic cells during beryllium sensitization
dual TLR2/9 recognition plays a critical role in providing resistance against mucosal infection with HSV
Mitochondrial DNA activates neutrophils via cyclic GMP-AMP synthase (cGAS)-STING and the Toll-like receptor 9 (TLR9) pathways and increases the production of neutrophil elastase and extracellular neutrophil-derived DNA in neutrophil extracellular traps.
TLR9 signaling in other cell types may promote cytoprotective effects.
TLR9-specific CPDP that targets both receptor dimerization and adapter recruitment.
Although most TLR9-CpG DNA interactions are conserved among species, some are unique to mice and involved in species-specificity. These findings provide the structural basis for how mouse TLR9 dimerizes efficiently in response to CpG DNA to activate innate immunity.
on repeated toll-like receptor 9 (TLR9) stimulation with unmethylated cytosine guanine dinucleotide containing single-stranded DNA (CpG), IL-18BP(-/-) mice display severe MAS manifestations, including increased weight loss, splenomegaly, anemia, thrombocytopenia, hyperferritinemia, and bone marrow hemophagocytosis as compared with wild-type mice.
Contact hypersensitivity immune response was markedly increased in TLR2-deficient or TLR9-deficient NOD mice.
These results suggest that TLR9 contributes to C57BL/6 mouse resistance against L. amazonensis, and that the TLR9-binding LaAg comprising CpG motifs may be important for intranasal vaccine efficacy against cutaneous leishmaniasis .
these results indicate clear responses of porcine neonatal antigen presenting cells after TLR2 and TLR9 stimulation
Porcine parvovirus virus infection significantly induced IL-6 expression and this induction depended on NF-kappaB activation and TLR9 signaling pathways in PK-15 cell.
TLR9 immunoreactivity is mainly detected in epithelial cells and antigen presenting cells, namely dendritic and macrophage-like cells, within the range of tissues examined. The pattern of TLR9 expression was similar in pigs of 3 weeks and 3 months of age.
These data demonstrated that TLR2, TLR3 and TLR9 contribute to NF-kappaB activation in response to porcine epidemic diarrhea virus infection, but not RIG-I.
expression of TLR3, TLR7 and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling.
variants in the TLR1 gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Toll-like receptor 9 protein