anti-LY96 (LY96) Antikörper

Human Lymphocyte Antigen 96 (LY96) Interaktionspartner

1. sTLR4/MD-2 complex inhibits colorectal cancer migration and invasiveness in vitro and in vivo by lncRNA H19 (zeige NCKAP1 Antikörper) down-regulation.

2. MD-2 siRNA or plasmid further confirmed the efficacy of Iturin A by suppressing MD-2/TLR4 (zeige TLR4 Antikörper) signaling pathway. The in silico docking study showed that the Iturin A interacted well with the MD-2 in MD-2/TLR4 (zeige TLR4 Antikörper) receptor complex. Conclusively, inhibition of MD-2/TLR4 (zeige TLR4 Antikörper) complex with Iturin A offered strategic advancement in cancer therapy.

3. data confirm that engineered human cells expressing TLR4 (zeige TLR4 Antikörper), MD2 and CD14 (zeige NDUFA2 Antikörper) can respond to CMP (zeige MATN1 Antikörper) with NF-kappaB (zeige NFKB1 Antikörper) activation and the response can be influenced by variations in CMP (zeige MATN1 Antikörper)-mannosylation

4. The observations suggest that MD-2 helps to regulate lipopolysaccharide-induced NLRP3 (zeige NLRP3 Antikörper) inflammasome activation and the inflammatory response in NR8383 cells, and likely does so by affecting MyD88 (zeige MYD88 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper) signaling.

5. MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.

6. we report that exogenous CnB (zeige PPP3R1 Antikörper) is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (zeige TLR4 Antikörper)/MD2 complex together with the co-receptor CD14 (zeige NDUFA2 Antikörper)

7. In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified.

8. Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 (zeige TLR4 Antikörper) signaling.

9. Predominantly hydrophobic interactions between MD-2 and TLR4 (zeige TLR4 Antikörper) contribute to the stabilization of the TLR4 (zeige TLR4 Antikörper)/MD-2/metal ion complex in a conformation that enables activation.

10. The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 (zeige TLR4 Antikörper) ligands may be facilitated through synthesis and release of sMD2 (zeige SNRPD2 Antikörper) by the amniochorion.

Mouse (Murine) Lymphocyte Antigen 96 (LY96) Interaktionspartner

1. Blockade of MD2 prevents obesity-induced inflammation and nephropathy.

2. MD2 is essential to obesity-related cardiac hypertrophy through activating JNK (zeige MAPK8 Antikörper)/ERK (zeige EPHB2 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper)-dependent cardiac inflammatory pathways. Targeting MD2 would be a therapeutic approach to prevent obesity-induced cardiac injury and remodeling.

3. RTFs contribute to the regulation of LPS (zeige TLR4 Antikörper)-induced inflammatory response in RAW264.7 cells through TLR4 (zeige TLR4 Antikörper)/MD-2 mediated NF-kappaB (zeige NFKB1 Antikörper) and JNK (zeige MAPK8 Antikörper) pathway. It

4. This study provides evidence that MD2 plays a key role in the pathogenesis of retinal I/R damage.

5. Data suggest that C4bp prevents interaction between Tlr4 (zeige TLR4 Antikörper)/MD-2 and its ligand; C4bp does not appear to interact with Tlr3 (zeige TLR3 Antikörper); C4bp binds to macrophage surface Tlr4 (zeige TLR4 Antikörper) and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 (zeige TLR4 Antikörper) activation. (C4bp = complement component 4 binding protein; Tlr = toll (zeige TLR4 Antikörper)-like receptor; MD-2 = myeloid differentiation protein-2)

6. MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.

7. Oxidative stress in retinal ischemia-reperfusion injury activates TLR4 (zeige TLR4 Antikörper) signaling via MD2.

8. Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4 (zeige TLR4 Antikörper)/MD-2 agonists need not mimic LPS (zeige TLR4 Antikörper)

9. Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 (zeige TLR4 Antikörper) ancillary molecule.

10. MD-2 is a critical regulator of the establishment of allergic airway sensitization to HDM (zeige HDAC3 Antikörper) in mice. Serum MD-2 may represent a potential biomarker for the amplification of allergic sensitization and allergic inflammation.