LY96 Antikörper (Center)

Produktnummer ABIN500262

Produktdetails anti-LY96 Antikörper

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LY96 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Ion exchange chromatography

Immunogen: MD-2 antibody was raised against a peptide corresponding to amino acids near the middle region of human MD-2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 to 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu LY96

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Andere Bezeichnung: MD-2 (LY96 Produkte)

Synonyme: MD2 antikoerper, ESOP-1 antikoerper, MD-2 antikoerper, ly-96 antikoerper, Ly-96 antikoerper, Md2 antikoerper, lymphocyte antigen 96 antikoerper, LY96 antikoerper, Ly96 antikoerper

Hintergrund: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2, e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2

NCBI Accession: NP_056179

UniProt: Q9Y6Y9

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades