TFEB Produkte
(Transcription Factor EB (TFEB))
Kategorien
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
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Ausgewählte TFEB Kategorien
TFEB Antikörper
High quality antibodies with extensive validation data.
TFEB Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TFEB Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (1)
- (5)
Kat. Nr.
ABIN563503
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (8)
Kat. Nr.
ABIN184741
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Cow, Dog, Goat, Horse, Human, Rabbit
Applikation
WB
Validierungen
- (5)
Kat. Nr.
ABIN2787554
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene TFEB ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative DNA-Binding ELISA
Validierungen
- (2)
- (2)
Kat. Nr.
ABIN5526704
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TFEB Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125448
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1786750
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN2733467
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TFEB Produkten
: "Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration." in: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Vol. 153, pp. 113328, (2022) (PubMed).: "Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR." in: Autophagy, Vol. 15, Issue 6, pp. 998-1016, (2019) (PubMed).
: "HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer." in: Autophagy, Vol. 14, Issue 3, pp. 385-403, (2019) (PubMed).
: "MITA modulated autophagy flux promotes cell death in breast cancer cells." in: Cellular signalling, Vol. 35, pp. 73-83, (2018) (PubMed).
: "Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation." in: Stem cell reports, Vol. 9, Issue 6, pp. 1853-1867, (2017) (PubMed).
: "TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1." in: The international journal of biochemistry & cell biology, Vol. 78, pp. 31-42, (2017) (PubMed).
: "Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals." in: Nature communications, Vol. 7, pp. 10944, (2016) (PubMed).
: "A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition." in: Autophagy, Vol. 12, Issue 8, pp. 1372-89, (2016) (PubMed).
: "Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture." in: Journal of virology, Vol. 89, Issue 20, pp. 10347-58, (2015) (PubMed).
: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." in: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).
Synonyme und alternative Namen zu TFEB
transcription factor EB (TFEB), transcription factor EB (tfeb), transcription factor EB (Tfeb), alphatfeb, ALPHATFEB, BHLHE35, bHLHe35, MGC145796, tcfeb, TCFEB, Tcfeb, TFEBBezeichner auf Proteinebene für TFEB
- transcription factor EB
- transcription factor EB-like
- T-cell transcription factor EB
- class E basic helix-loop-helix protein 35
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