Rekombinanter TFEB Antikörper (C-Term)

Produktnummer ABIN7795623

Der Kaninchen Monoklonal anti-TFEB Antikörper wird verwendet zum Nachweis von TFEB in Proben von Human und Maus. Er wurde validiert für WB, FACS und IP.

Kurzübersicht für Rekombinanter TFEB Antikörper (C-Term) (ABIN7795623)

Target: TFEB (Transcription Factor EB (TFEB))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TFEB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Klon: BLR070G

Produktdetails anti-TFEB Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit anti-TFEB Recombinant Monoclonal Antibody [BLR070G] - BSA-Free

Aufreinigung: Purified

Immunogen: Between 426 and C-terminus

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1000 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.09 % Sodium Azide, BSA-Free

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2 - 8 °C

Haltbarkeit: 12 months

Details zu TFEB

Target: TFEB (Transcription Factor EB (TFEB))

Andere Bezeichnung: TFEB

Hintergrund: Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P19484].

Gen-ID: 7942

UniProt: P19484