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Expression level of RFC4 was up regulated in cervical squamous cell carcinoma.
RFC4 is frequently overexpressed in CRC, and is associated with tumor progression and worse survival outcome. This might be attributed to the regulation of CRC cell proliferation and cell cycle arrest by RFC4
The knockdown of endogenous replication factor C4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cells.
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.
replication factor C subunit 4
, Replication factor C subunit 4
, activator 1 subunit 4
, A1 37 kDa subunit
, RF-C 37 kDa subunit
, RFC 37 kDa subunit
, activator 1 37 kDa subunit
, replication factor C 37 kDa subunit
, replication factor C p37 subunit
, replication factor C 4