This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].
Foidl, Humpel: "Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid." in: Frontiers in aging neuroscience, Vol. 10, pp. 113, (2018) (PubMed).
Aliase für tau Proteine
microtubule associated protein tau (MAPT) Proteine DDPAC Proteine FTDP-17 Proteine MAPTL Proteine MSTD Proteine MTBT1 Proteine MTBT2 Proteine PHF-tau Proteine PPND Proteine TAU Proteine tau Proteine