anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antikörper

Bezeichnung:: anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antikörper (APBA1)

Auf www.antikoerper-online.de finden Sie aktuell 79 Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antikörper von 22 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 89 Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Produkte verfügbar.

Synonyme:: 6430513E09Rik, APBA1, D9S411E, Lin-10, LIN10, Mint, MINT1, Urop11, X11, X11A, X11ALPHA

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	APBA1	319924	B2RUJ5
	APBA1	83589	O35430
	APBA1	320	Q02410
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Verknüpfte Pathways mit anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antikörper

Am meisten referenzierte anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antikörper

Mouse (Murine) Monoclonal APBA1 Primary Antibody für IF, IHC - ABIN968327 : Biederer, Südhof: Mints as adaptors. Direct binding to neurexins and recruitment of munc18. in The Journal of biological chemistry 2001 (PubMed)
Show all 4 Pubmed References
Mouse (Murine) Monoclonal APBA1 Primary Antibody für IF, IHC - ABIN968328 : Wong, Setou, Teng, Takei, Hirokawa: Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
Show all 4 Pubmed References
Human Polyclonal APBA1 Primary Antibody für ELISA, WB - ABIN1003416 : Verlaeten, Casery, Cavagna, Naville, Giraudon, Belin, Begeot, Bernard: Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity. in Journal of molecular endocrinology 2007 (PubMed)
Human Polyclonal APBA1 Primary Antibody für ELISA, WB - ABIN451592 : Jacobs, Williams, Francis: Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease. in Neuroscience 2006 (PubMed)
Rat (Rattus) Polyclonal APBA1 Primary Antibody für ICC, IHC - ABIN1742315 : Boyken, Grønborg, Riedel, Urlaub, Jahn, Chua: Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. in Neuron 2013 (PubMed)

Weitere Antikörper gegen Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Interaktionspartner

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Interaktionspartner

Results indicate that both X11 and X11L (zeige APBA2 Antikörper) exert largely in brain neurons, but X11 may also function in peripheral tissues.
Due to the multiple interacting partners of X11alpha, dysfunction or alteration in X11alpha will have a significant cellular effect.
Mint1 826 bridges APP (zeige APP Antikörper) to the small GTPase (zeige RACGAP1 Antikörper)
Expression of Apba1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (zeige UTS2R Antikörper) of Comt (catechol-O-methyltransferase (zeige COMT Antikörper)).
Our data support a function for both GSK3 and CDK5 (zeige CDK5 Antikörper) in amyloid precursor protein (zeige APP Antikörper) processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease.
Can be considered a key molecule in the hypothalamic integration pathway, important as a target of leptin (zeige LEP Antikörper) action.
Reports have demonstrated that KIF17 (zeige KIF17 Antikörper)-Mint1 association was disrupted and transported cargo was released from its microtubule-based transport when Ser (zeige SIGLEC1 Antikörper) 1029 of KIF17 (zeige KIF17 Antikörper) was phosphorylated.
X11s associate primarily with APP (zeige APP Antikörper) molecules that are outside of DRM (zeige GREM1 Antikörper), that the dissociation of APP (zeige APP Antikörper)-X11/X11L (zeige APBA2 Antikörper) complexes leads to entry of APP (zeige APP Antikörper) into DRM (zeige GREM1 Antikörper), and that cleavage of uncomplexed APP (zeige APP Antikörper) by BACE (zeige BACE Antikörper) within DRM (zeige GREM1 Antikörper)
These results suggest that the three Mint/X11 proteins regulate Abeta (zeige APP Antikörper) production by a novel mechanism that may have implications for therapeutic approaches to altering APP (zeige APP Antikörper) cleavage in Alzheimer's disease.

Human Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Interaktionspartner

Mint1 causes amyloid precursor protein (zeige APP Antikörper) accumulation in the trans-Golgi network.
Mints are necessary for activity-induced APP (zeige APP Antikörper) and PS1 (zeige PSEN1 Antikörper) trafficking and provide insight into the cellular fate of APP (zeige APP Antikörper) in endocytic pathways essential for Abeta (zeige APP Antikörper) production.
Mint1 826 bridges APP (zeige APP Antikörper) to the small GTPase (zeige RACGAP1 Antikörper)
an autoinhibitory mechanism in Mint1 is important for regulating APP (zeige APP Antikörper) processing and may provide novel therapies for Alzheimer's disease
Transcriptional co-activators Taz (zeige TAZ Antikörper) and Yap (zeige YAP1 Antikörper) mediate signaling via the amyloid beta protein precursor paralogues APLP1 (zeige APLP1 Antikörper) and APLP2 (zeige APLP2 Antikörper) through interactions with Mint1 and Mint3 (zeige APBA3 Antikörper).
Study identified the conserved binding site for the peptide on the CASK (zeige CASK Antikörper) calmodulin kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding.
Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.
Methylation of MINT1 was significantly more prevalent in UC-CRC (zeige CALR Antikörper) cases compared with controls.
ApoEr2 (zeige LRP8 Antikörper) regulates cell movement, and both X11alpha and Reelin (zeige RELN Antikörper) enhance this effect.
A novel consensus sequence for interaction with the PDZ (zeige INADL Antikörper)-1 and PDZ (zeige INADL Antikörper)-2 domains of amyloid precursor protein (APP (zeige APP Antikörper))-interacting proteins Mint1, Mint2 (zeige APBA2 Antikörper), and Mint3 (zeige APBA3 Antikörper) is reported, with multiple novel interactors for these proteins.

Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

Alternative names and synonyms associated with Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1)

amyloid beta precursor protein binding family A member 1 (APBA1) Antikörper
amyloid beta (A4) precursor protein-binding, family A, member 1b (apba1b) Antikörper
ketopantoate reductase (apbA1) Antikörper
2-dehydropantoate 2-reductase (apbA1) Antikörper
2-dehydropantoate 2-reductase (apba1) Antikörper
amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) (apba1) Antikörper
amyloid beta (A4) precursor protein-binding, family A, member 1 (apba1) Antikörper
amyloid beta (A4) precursor protein binding, family A, member 1 (Apba1) Antikörper
amyloid beta precursor protein binding family A member 1 (Apba1) Antikörper

6430513E09Rik Antikörper
APBA1 Antikörper
D9S411E Antikörper
Lin-10 Antikörper
LIN10 Antikörper
Mint Antikörper
MINT1 Antikörper
Urop11 Antikörper
X11 Antikörper
X11A Antikörper
X11ALPHA Antikörper

Bezeichner auf Proteinebene für APBA1

amyloid beta (A4) precursor protein-binding, family A, member 1 , amyloid beta A4 precursor protein-binding, family A, member 1 , amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , ketopantoate reductase , 2-dehydropantoate 2-reductase , Amyloid beta A4 precursor protein-binding family A member 1 , amyloid beta A4 precursor protein-binding family A member 1-like , UROP11-110 , adapter protein X11alpha , amyloid beta A4 precursor protein-binding family A member 1 , mint-1 , neuron-specific X11 protein , neuronal Munc18-1-interacting protein 1 , amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11) , amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , adaptor protein X11alpha , neuronal munc18-1-interacting protein 1 , phosphotyrosine-binding/-interacting domain (PTB)-bearing protein

GENE ID	SPEZIES
472947	Pan troglodytes
565507	Danio rerio
699838	Macaca mulatta
4247161	Ralstonia eutropha H16
4606254	Azoarcus sp. BH72
9788884	Pantoea vagans C9-1
100380423	Salmo salar
100390315	Callithrix jacchus
100439123	Pongo abelii
100483732	Ailuropoda melanoleuca
100485825	Xenopus (Silurana) tropicalis
319924	Mus musculus
83589	Rattus norvegicus
320	Homo sapiens
427246	Gallus gallus
100686233	Canis lupus familiaris
100513711	Sus scrofa
515571	Bos taurus

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Show all anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antikörper with Pubmed References

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Interaktionspartner

Human Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1)

Bezeichner auf Proteinebene für APBA1