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Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.
syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) , 59 kDa dystrophin-associated protein A1 acidic component 1 , alpha-1-syntrophin , alpha1-syntrophin , syntrophin-1 , acidic alpha 1 syntrophin , dystrophin-associated protein A1, 59kDa, acidic component , pro-TGF-alpha cytoplasmic domain-interacting protein 1 , syntrophin, acidic 1 , 59-1 DAP , alpha-syntrophin
GENE ID | SPEZIES |
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6640 | Homo sapiens |
362242 | Rattus norvegicus |
485837 | Canis lupus familiaris |
100151843 | Sus scrofa |
100009179 | Oryctolagus cuniculus |
527488 | Bos taurus |