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Human COMT ELISA Kit für Sandwich ELISA - ABIN481734
Karpeta, Warzecha, Jerzak, Ptak, Gregoraszczuk: Activation of the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism by 2,2',4,4'-tetrabromodiphenyl ether (BDE47) in the pig ovary. in Reproductive toxicology (Elmsford, N.Y.) 2012
Our results are consistent with the major role of COMT in modulating dopamine flux in the prefrontal cortex and its association with schizophrenia and cognitive function. Regarding this association with the disorder, we found a significant effect of rs737865 genotypes in schizophrenia and of rs4680/rs165599 haplotypes, with an effect opposite to that observed in European populations.
The results show significant interaction between the effects of the COMT genotype and trauma in commission errors. In participants with ADHD carrying the COMT Val/Val genotype, the group exposed to trauma showed significantly higher commission errors than the non-traumatized group
results indicate that the COMT Val158Met polymorphism is a vulnerability factor for major depressive disorder with distinct effects in different ethnic populations (meta-analysis).
Sex-dependent effect of COMT Va l158Met polymorphism on decision-making.
COMT Val158Met polymorphism does not seem to be involved in smooth pursuit eye movement (SPEM) dysfunction, deficits in P50 (zeige CD40 ELISA Kits) auditory-evoked potential inhibition, and saccadic inhibition deficits.
Childhood trauma interacts with haplotypes in COMT, MAOA (zeige MAOA ELISA Kits) and MAOB (zeige MAOB ELISA Kits), increasing risk for OCD.
This study demonstrates the contribution of the COMT Val158Met polymorphism to individual differences in well-being and suggests a potential psychobiological pathway from dopaminergic and noradrenergic systems to happiness.
The KCNJ6 (zeige KCNJ6 ELISA Kits) -1250A and COMT Val alleles are predisposing preterm newborns to diminished opioid-induced pain relief.
found differences in Neonatal Abstinence Syndrome outcomes depending on PNOC (zeige PNOC ELISA Kits) and COMT SNP genotype.
The present findings suggest that COMT Val(108/158)Met polymorphism may not contribute to the risk of schizophrenia and to the P50 sernsory gating deficits, but may contribute to the negative symptoms of schizophrenia among Han Chinese.
Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (zeige CFP ELISA Kits)) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (zeige DTNBP1 ELISA Kits).
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol-O-methyltransferase 1
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form