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anti-Human OCT4 Antikörper:
anti-Rat (Rattus) OCT4 Antikörper:
anti-Mouse (Murine) OCT4 Antikörper:
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Human Monoclonal OCT4 Primary Antibody für CyTOF, FACS - ABIN4899037
Rajesh, Chinnasamy, Mitalipov, Wolf, Slukvin, Thomson, Shaaban: Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. in Stem cells (Dayton, Ohio) 2007
Show all 13 Pubmed References
Human Polyclonal OCT4 Primary Antibody für ICC, FACS - ABIN250770
Yenamandra, Darekar, Kashuba, Matskova, Klein, Kashuba: Stem cell gene expression in MRPS18-2-immortalized rat embryonic fibroblasts. in Cell death & disease 2012
Show all 8 Pubmed References
Human Monoclonal OCT4 Primary Antibody für FACS - ABIN4895355
Huijbers, Bin Ali, Pritchard, Cozijnsen, Kwon, Proost, Song, de Vries, Badhai, Sutherland, Krimpenfort, Michalak, Jonkers, Berns: Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. in EMBO molecular medicine 2014
Show all 7 Pubmed References
Human Monoclonal OCT4 Primary Antibody für FACS - ABIN4895354
Kim, Gwak, Han, Park, Park, Song, Cho, Rhee, Chung, Kim: Kidney tissue reconstruction by fetal kidney cell transplantation: effect of gestation stage of fetal kidney cells. in Stem cells (Dayton, Ohio) 2007
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Human Monoclonal OCT4 Primary Antibody für BI, IF - ABIN968417
Nishimoto, Fukushima, Okuda, Muramatsu: The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. in Molecular and cellular biology 1999
Show all 6 Pubmed References
Human Monoclonal OCT4 Primary Antibody für BI, IF - ABIN1176919
Okamoto, Okazawa, Okuda, Sakai, Muramatsu, Hamada: A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. in Cell 1990
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Human Monoclonal OCT4 Primary Antibody für BI, IF - ABIN968418
Rosfjord, Scholtz, Lewis, Rizzino: Phosphorylation and DNA binding of the octamer binding transcription factor Oct-3. in Biochemical and biophysical research communications 1995
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Human Polyclonal OCT4 Primary Antibody für ChIPSeq, ChIP - ABIN2668652
Zechel: Requirement of retinoic acid receptor isotypes alpha, beta, and gamma during the initial steps of neural differentiation of PCC7 cells. in Molecular endocrinology (Baltimore, Md.) 2005
Show all 4 Pubmed References
Human Monoclonal OCT4 Primary Antibody für ELISA, WB - ABIN969330
Zhang, Zhang, Wang, Esteban, Pei: Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. in The Journal of biological chemistry 2008
Show all 3 Pubmed References
Dog (Canine) Polyclonal OCT4 Primary Antibody für WB - ABIN2792671
Suo, Han, Wang, Zhang, Zhao, Zhao, Dai: Oct4 pseudogenes are transcribed in cancers. in Biochemical and biophysical research communications 2005
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Low expressions of Oct4-EpCAM in IHC and CD133 in qPCR may reveal roles in gastric cancer
The prevalence of Oct-3/4 and D2-40-positive staining of germ cells in testicular biopsies of boys with cryptorchidism were in age groups less than 6 months, 100% and 50%; 6-12 months, 60% and 17%; and 1-2 years, 12% and 4%. In all cases, the Oct-3/4 and D2-40 positive germ cells turned negative and the histological pattern normalized completely with age.
Our results indicate that Oct4 expression is associated with aggressive features, ALDH1 (zeige ALDH1A1 Antikörper) expression, tamoxifen resistance and poor clinical outcomes in hormone receptor (zeige NR4A1 Antikörper)-positive breast cancer, and thus may be useful as a predictive and prognostic marker in this subgroup of breast cancer.
Rectal tumor tissue OCT4 (p<0.001), SOX2 (p=0.003), and NANOG (p<0.001) expressions were higher than those in adjacent tissue.
Novel spliced variants of OCT4, OCT4C and OCT4C1, with distinct expression patterns and functions in pluripotent and tumor cell lines have been described.
we have provided evidence that Oct4 expression is enhanced in bladder cancer cells after treatment with various chemotherapeutic agents, rendering bladder cancer chemoresistant.
our study describes the relationship between ABCG2 and OCT-4 expression and the clinicopathological characteristics of RCC (zeige XRCC1 Antikörper) patients. ABCG2 and OCT-4 expression was significantly correlated with RCC (zeige XRCC1 Antikörper) recurrence, which has a poor prognosis.
we confirmed that up-regulated KPNA2 (zeige KPNA2 Antikörper) and OCT4 expression is a common feature of bladder cancer that is correlated with increased aggressive tumor behavior. Also, we propose that KPNA2 (zeige KPNA2 Antikörper) regulates the process of OCT4 nuclear transportation in bladder cancer.
Knockdown of OCT4 in NSCLC cells could decrease cell proliferation, and potentiate apoptosis induced by gefitinib, suggesting OCT4 may contribute to gefitinib resistance in NSCLC.
Data show that lung adenocarcinoma SPC-A1 cell differentiated by a two-stage induction (TSI) method lost stem cell characteristics, including absent expression of OCT4 and Nanog.
Cytoplasmic CD44 (zeige CD44 Antikörper) and absence of nuclear Oct3/4 suggest that the cells of cardiac sarcomas may represent 'daughter' stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation.
Lack of restricted OCT4 protein, and inner cell mass localization of NANOG in primate blastocysts, suggests that NANOG may determine inner cell mass fate more specifically during primate development.
The authors show, at single-cell resolution in vivo, that Pou5f3 complexes with Nanog to pattern mesendoderm differentiation at the blastula stage.
Data suggest that, in developing gastrula, Znfl1 controls developmental gene expression of Hoxb1b in embryonic posterior neuroectoderm by acting upstream of Pou5f3 and Sall4 (zeige SALL4 Antikörper); these proteins appear to be involved in neurogenesis. (Znfl1 = zinc finger-like gene 1; Hoxb1b = homeobox B1b protein; Pou5f3 = POU domain class 5 transcription factor 3 (zeige TCF3 Antikörper); Sall4 (zeige SALL4 Antikörper) = spalt (zeige SALL1 Antikörper)-like transcription factor 4 (zeige TCF4 Antikörper))
Regulation of mych by Pou5f1 appears to be direct transcriptional activation.
The posttranslational modification by phosphorylation opens the possibility that Pou5f1 may be subject to temporal or region specific modulation of its activity or stability by embryonic signaling mechanisms.
discuss mechanistic implications of simultaneous activation of transcriptional targets by ubiquitous, like Pou5f1, and region-specific inducers, emerging as a common regulatory motif in early development
maternal Nanog (zeige NANOG Antikörper), Pou5f1 and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (zeige MYLIP Antikörper)-430 expression
thses data position Pou5f1 and SOX (zeige PIPOX Antikörper)-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control.
The defects due to HEP induction were rescued by introducing wild-type pou2 mRNA before the heat treatments.
Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system.
Pou2 functions in multiple aspects of vertebrate development, especially in the binary decision of the mesendoderm to mesoderm and endoderm in different ways depending on the developmental stage.
sequences of mRNA and translated protein of the newly identified genes and those of POU5F1 were aligned to their mammalian orthologs to determine the degree of evolutionary conservation
Higher values of OCT-4 expression were observed in embryos and endometrial tissue in females reproduced under heat conditions.
protein expression during rabbit embryonic development: investigation of temporal and spatial relationship of expression of Oct-4, Cdx-2 (caudal type homeobox transcription factor 2 (zeige CDX2 Antikörper)) and histone H4 (acetylated at lysine 5) in morula/blastocysts
The signal may have reflected the regulation of Oct-4 through enhancer switching and therefore may be related to cell lineage formation in rabbit embryos.
The POU5F1 gene is strictly regulated during early embryo development.
The results revealed that the synthesized complex decoy can concomitantly target Sox2 (zeige SOX2 Antikörper) and Oct4, which subsequently represses the stemness properties of mESCs compared to controls through decreasing cell viability, arresting cell cycle in G0 /G1 phases, inducing apoptosis, and modulating differentiation in mESCs despite the presence of 2i/LIF (zeige LIF Antikörper) in cell culture.
Tip110 deletion impaired embryonic and stem cell development involving downregulation of stem cell factors Nanog (zeige NANOG Antikörper), Oct4, and Sox2 (zeige SOX2 Antikörper).
Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc (zeige MYC Antikörper), Sox2 (zeige SOX2 Antikörper) and Klf4 (zeige KLF4 Antikörper).
Nanog (zeige NANOG Antikörper), Oct4 and Tet1 (zeige TET1 Antikörper) interplay in establishing stem cell pluripotency has been described.
The positive feedback regulation of OCT4 and c-JUN (zeige JUN Antikörper), resulting in the continuous expression of oncogenes such as c-JUN (zeige JUN Antikörper), seems to play a critical role in the determination of the cell fate decision from induced pluripotent stem cells to cancer stem cells in liver cancer.
Folate receptor alpha (zeige FOLR1 Antikörper) upregulates Oct4, Sox2 (zeige SOX2 Antikörper) and Klf4 (zeige KLF4 Antikörper) and downregulates miR (zeige MLXIP Antikörper)-138 and miR (zeige MLXIP Antikörper)-let-7 in cranial neural crest cells.
Chromatin accessibility at OCT4-bound sites requires the chromatin remodeller BRG1 (zeige SMARCA4 Antikörper), which is recruited to these sites by OCT4 to support additional transcription factor binding and expression of the pluripotency-associated transcriptome.
data infer that OCT4 expression may have a direct effect on partial cardiomyocyte reprogramming of MSCs and suggest a new mechanism(s) associated with MSC (zeige MSC Antikörper) multipotency and a requirement for crosstalk with the cardiac microenvironment
Regulation of Oct4 by SirT1 (zeige SIRT1 Antikörper) may link stem cell development to environmental conditions, and it may provide strategies to manipulate epiblast cell state.
we suggest that the activity of Oct4 DE and PE is regulated by the repressive histone marks and DNA methylation (zeige HELLS Antikörper) in a cell-type-specific manner.
Activin A (zeige INHBA Antikörper) and overexpression of SMAD2 (zeige SMAD2 Antikörper)/3 significantly promoted expressions of porcine NANOG (zeige NANOG Antikörper) and OCT4,maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Antikörper)/OCT4 expression.
Our results indicate that continuous expression of OCT-4 in blastomeres is essential for trophectoderm formation of porcine embryos.
These findings suggest that the 12-bp indel polymorphism of the Oct4 gene might be a potential DNA marker for selecting preferred individuals in relation to reproductive traits in pig marker-assisted selection breeding.
Oct4-overexpression enhances porcine ovarian stem cell differentiation in to oocyte-like cells.
showed novel molecular regulation of CDX2 (zeige CDX2 Antikörper) on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 (zeige CDX2 Antikörper) and Oct4 in embryo of mammals other than mouse
Overexpression of Sox2 (zeige SOX2 Antikörper) or Oct4 in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (zeige FGF2 Antikörper) results in higher proliferation and differentiation compared to controls.
Oct4 positive stem/progenitor swine lung epithelial cells are targets for influenza virus replication.
study shows that localization of octamer-binding protein 4(OCT4) is associated with an embryonic stem cell (ESC)-like morphology from porcine inner cell mass
OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level.
we concluded that OCT4 expression in somatic cells is not a good prognosis marker for selecting cell lines.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Oct4 exhibited significant hypermethylation in sperm compared with that in oocytes
In contrast to protein distribution, regulation of Oct4 transcription is conserved between mammalian species.
analysis of CpG islands of bovine Leptin (zeige LEP Antikörper) and POU5F1 genes in cloned bovine fetuses
The restoration of pluripotency can be directly observed in living cells or SCNT embryos from such Pou5f1-EGFP transgenic fetuses.
Oct4 cDNA and a 2.8-kb regulatory region upstream of its start codon were isolated and characterized
evaluated pattern of POU5F1 expression during early embryo development;study shows POU5F1 protein is present in cytoplasm and nucleus of immature oocytes, decreases during embryo development to day 5, then increases again within embryonic nuclei [POU5F1]
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6\;22)(p21\;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
POU domain transcription factor OCT4
, POU domain, class 5, transcription factor 1
, POU-type homeodomain-containing DNA-binding protein
, octamer-binding protein 3
, octamer-binding protein 4
, octamer-binding transcription factor 3
, octamer-binding transcription factor-3
, POU class 5 homeobox 1
, POU domain class 5 transcription factor 1
, POU domain gene 2
, spiel ohne grenzen
, spiel ohne grenzen/pou2
, octamer binding transcription factor 4
, Octamer-binding transcription factor 3
, octamer-binding transcription factor 4