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Human Polyclonal LIN28A Primary Antibody für ICC, IF - ABIN4331040
Boj, Hwang, Baker, Chio, Engle, Corbo, Jager, Ponz-Sarvise, Tiriac, Spector, Gracanin, Oni, Yu, van Boxtel, Huch, Rivera, Wilson, Feigin, Öhlund, Handly-Santana, Ardito-Abraham, Ludwig, Elyada et al.: Organoid models of human and mouse ductal pancreatic cancer. ... in Cell 2015
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Human Monoclonal LIN28A Primary Antibody für ICC, ELISA - ABIN968936
Gerecht-Nir, Dazard, Golan-Mashiach, Osenberg, Botvinnik, Amariglio, Domany, Rechavi, Givol, Itskovitz-Eldor: Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. in Developmental dynamics : an official publication of the American Association of Anatomists 2005
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LIN28 is a very specific marker (98% specificity) for distinguishing classic gastric hepatoid carcinomas from hepatocellular carcinoma
Data indicated that LIN28A might make contribution to HSF (zeige HSF1 Antikörper) proliferation and extracellular matrix synthesis upon thermal injury.
LIN28A inhibits lysosomeassociated membrane glycoprotein (zeige CD86 Antikörper) 1 protein expression in embryonic stem and bladder cancer cells.
Studied effects of lin-28 homolog A protein (Lin28A) on cells proliferation, migration, invasion and apoptosis of osteocarcinoma (OS) cells through metastasis associated lung adenocarcinoma transcript 1 (MALAT1).
Pig induced pluripotent stem cell (piPSC) line was generated from embryonic fibroblast cells using retroviral transduction approaches carrying human transcriptional factors: OCT4 (zeige POU5F1 Antikörper), SOX2 (zeige SOX2 Antikörper), KLF4 (zeige KLF4 Antikörper), c-MYC (zeige MYC Antikörper) and LIN28.
LIN28A is a sensitive IHC marker for the diagnosis of Embryonal Tumor with Multilayered Rosettes , but immunoreactivity can also be seen in a proportion of Atypical Teratoid/Rhabdoid Tumors
Recent improvement in high-throughput sequencing has highlighted the potential role of LIN28/let-7 regulatory network in several developmental events. It was proposed that this pathway might represent a functional signature in cell proliferation, transition between commitment and pluripotency, and regulation of cancer and tumorigenicity.
Knockdown of miR (zeige MLXIP Antikörper)-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia (zeige BCL11A Antikörper).
Lin28A and Lin28B (zeige LIN28B Antikörper) are co-expressed colon cancer tissues and have functional similarities.
this study demonstrates that Lin28A can activates androgen receptor (zeige AR Antikörper) via regulation of c-myc (zeige MYC Antikörper) and promotes malignancy of ER-/Her2 (zeige ERBB2 Antikörper)+ breast cancer
Overexpression of Lin28a, an RNA-binding protein that regulates organismal growth and metabolism, in articular chondrocyte progenitor cells upregulated Erk (zeige EPHB2 Antikörper) signaling and increased articular cartilage thickness.
The apoptotic protection by Lin28a inhibition is likely through the activation of TrkA (zeige NTRK1 Antikörper) signaling pathway.
In the absence of Eprn, Lin28a expression is reduced which results in persistence of let-7 microRNAs, and the up-regulation of de novo methyltransferases Dnmt3a (zeige DNMT3A Antikörper)/b is delayed. Dnmt3a (zeige DNMT3A Antikörper)/b deletion retards ES cell transition, correlating with delayed Nanog (zeige NANOG Antikörper) promoter methylation and phenocopying loss of Eprn or Lin28a.
miR (zeige MLXIP Antikörper)-145 modulation of Sox2 (zeige SOX2 Antikörper)-Lin28/let-7 network is crucial for neurogenesis progression.
the specific interaction between zinc knuckle domain of LIN28 and pre-let-7 is necessary and sufficient to induce oligouridylation.
The results reveal a key role of Wnt (zeige WNT2 Antikörper)-Lin28-let7 miRNA signaling in regulating proliferation and neurogenic potential of Muller glial cells in the adult mammalian retina.
LIN28 specifically marks undifferentiated spermatogonia in mice. The LIN28-expressing undifferentiated spermatogonia exist as two subpopulations: Ngn3 (zeige NEUROG3 Antikörper)-GFP-negative (high stem cell potential) and Ngn3 (zeige NEUROG3 Antikörper)-GFP-positive (high differentiation commitment)
Overexpression of LIN28A, which is a hallmark of human ETMRs, augments Sonic-hedgehog (Shh (zeige SHH Antikörper)) and Wnt (zeige WNT2 Antikörper) signaling in embryonal tumors with multilayered rosettes precursor cells through the downregulation of let7-miRNA, and LIN28A/let7a interaction with the Shh (zeige SHH Antikörper) pathway was detected at the level of Gli (zeige GLI1 Antikörper) mRNA.
During ESC differentiation, Lin28 transient induction is dependent on Otx2 and Hmga2 and prevents an inappropriate excessive rise of Hmga2 levels.-
the role of Lin28 in controlling developmental transitions is evolutionary conserved and establishes a functional interaction between Lin28 and thyroid hormone (zeige PTH Antikörper) function.
The knockdown of Lin-28a or Lin-28b (zeige LIN28B Antikörper) function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.
The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.
Lin28 pseudogenes do not acquire patterns of tissue-specific methylation as for the parental gene, but rather are methylated in patterns specific to the local genomic environment into which they were inserted.
Dual-luciferase reporter assay validated that miR (zeige MYLIP Antikörper)-370, one of the 16 common microRNAs, could directly target the 3'UTR (zeige UTS2R Antikörper) of LIN28A.
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).
RNA-binding protein LIN-28
, protein lin-28 homolog A
, zinc finger CCHC domain-containing protein 1
, zinc finger, CCHC domain containing 1
, testis expressed gene 17
, testis-expressed protein 17
, RNA-binding protein LIN-28A
, RNA-binding protein lin-28
, lin-28 homolog A (C. elegans)