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Sonic Hedgehog Produkte

(Sonic Hedgehog (SHH))
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008].

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Ausgewählte Sonic Hedgehog Kategorien

Sonic Hedgehog Antikörper

High quality antibodies with extensive validation data.

Sonic Hedgehog ELISA Kits

Reliable ELISA kits for a wide range of species.

Sonic Hedgehog Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Sonic Hedgehog Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Pig, Rat
Applikation WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validierungen
  • (10)
  • (6)
Kat. Nr. ABIN731108
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Monkey, Mouse
Applikation WB, IHC, ELISA, FACS
Validierungen
  • (1)
  • (6)
Kat. Nr. ABIN969567
Menge 0.1 mg
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, ELISA, IF, FACS
Validierungen
  • (5)
Kat. Nr. ABIN6391361
Menge 100 μg
Datenblatt Datenblatt

Empfohlene Sonic Hedgehog ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
  • (4)
Kat. Nr. ABIN6730870
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (5)
Kat. Nr. ABIN6574290
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN6975108
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Sonic Hedgehog Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (3)
Kat. Nr. ABIN2018361
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
  • (3)
Kat. Nr. ABIN2018373
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (2)
Kat. Nr. ABIN7275581
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Sonic Hedgehog Produkten

Beyer, Huscher, Ramming, Bergmann, Avouac, Guiducci, Meier, Vettori, Siegert, Jaeger, Maurer, Riemekasten, Walker, Müller-Ladner, Valentini, Matucci-Cerinic, Allanore, Distler, Schett, Distler: "Elevated serum levels of sonic hedgehog are associated with fibrotic and vascular manifestations in systemic sclerosis." in: Annals of the rheumatic diseases, Vol. 77, Issue 4, pp. 626-628, (2019) (PubMed).

Tessier, Madhu, Johnson, Shapiro, Risbud: "NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis." in: Developmental biology, (2019) (PubMed).

Gao, Li, Li: "Exendin-4 promotes the osteogenic differentiation of osteoblasts via the Hedgehog/Gli1 signaling pathway." in: American journal of translational research, Vol. 10, Issue 1, pp. 315-324, (2018) (PubMed).

Morales-Hernández, Nacarino-Palma, Moreno-Marín, Barrasa, Paniagua-Quiñones, Catalina-Fernández, Alvarez-Barrientos, Bustelo, Merino, Fernández-Salguero: "Lung regeneration after toxic injury is improved in absence of dioxin receptor." in: Stem cell research, Vol. 25, pp. 61-71, (2018) (PubMed).

Kaushal, Popli, Sankhwar, Shukla, Dwivedi: "Sonic hedgehog protects endometrial hyperplasial cells against oxidative stress via suppressing mitochondrial fission protein dynamin-like GTPase (Drp1)." in: Free radical biology & medicine, Vol. 129, pp. 582-599, (2018) (PubMed).

Fan, Li, Liu, Cong, Zhao, Cao, Zheng: "Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 163, (2018) (PubMed).

Yang, Wu, Feng, Huang, Liu, Liu, Chen: "Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 267, (2017) (PubMed).

Song, Du, Tao: "Blockade of sonic hedgehog signaling decreases viability and induces apoptosis in retinoblastoma cells: The key role of the PI3K/Akt pathway." in: Oncology letters, Vol. 14, Issue 4, pp. 4099-4105, (2017) (PubMed).

Lozito, Tuan: "Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration." in: Development (Cambridge, England), Vol. 143, Issue 16, pp. 2946-57, (2016) (PubMed).

Valverde, Pereira, Dias, Guimarães, Ramos, Santos, Gurgel Rocha: "Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation." in: Tumour biology, Vol. 37, Issue 7, pp. 9233-41, (2016) (PubMed).

Synonyme und alternative Namen zu Sonic Hedgehog

sonic hedgehog (SHH), sonic hedgehog (Shh), sonic hedgehog a (shha), sonic hedgehog L homeolog (shh.L), sonic hedgehog (shh), sonic hedgehog protein A (shh), sonic hedgehog b (shhb), 9530036O11Rik, Dsh, fc83d08, hedgehog, HHG1, Hhg1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, shh, SHH, SMMCI, syu, TPT, TPTPS, twh, twhh, vhh-1, vhh1, wu:fc83d08, Xhh, xshh

Bezeichner auf Proteinebene für Sonic Hedgehog

  • sonic hedgehog homolog
  • sonic hedgehog protein
  • HHG-1
  • hemimelic extra toes
  • short digits
  • sonic hedgehog protein A
  • sonic-you
  • VHH-1
  • X-SHH
  • morphogen
  • sonic hedgehog
  • sonic hedgehog protein B
  • tiggy winkle hedge hog
  • tiggy winkle hedgehog
  • tiggy-winkle hedgehog protein
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