SLC12A1 Produkte
(Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))
Kategorien
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010].
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Ausgewählte SLC12A1 Kategorien
SLC12A1 Antikörper
High quality antibodies with extensive validation data.
SLC12A1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SLC12A1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene SLC12A1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Applikation
WB, IHC
Validierungen
- (3)
- (5)
Kat. Nr.
ABIN2776780
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN7131078
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Rat
Applikation
WB, IHC
Validierungen
- (4)
- (2)
Kat. Nr.
ABIN863200
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene SLC12A1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6970295
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959560
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN579532
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene SLC12A1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1320125
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1320127
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN3087799
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren SLC12A1 Produkten
: "Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways." in: Journal of the American Heart Association, Vol. 6, Issue 10, (2018) (PubMed).: "Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma." in: Molecular cancer, Vol. 15, pp. 10, (2016) (PubMed).
: "Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice." in: American journal of physiology. Renal physiology, Vol. 311, Issue 4, pp. F752-F762, (2016) (PubMed).
: "Prostaglandin-E2 Mediated Increase in Calcium and Phosphate Excretion in a Mouse Model of Distal Nephron Salt Wasting." in: PLoS ONE, Vol. 11, Issue 7, pp. e0159804, (2016) (PubMed).
: "Regulation of the Na(+) -K(+) -2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration." in: The FEBS journal, (2015) (PubMed).
: "Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease." in: Scientific reports, Vol. 5, pp. 12480, (2015) (PubMed).
: "Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK." in: American journal of physiology. Renal physiology, Vol. 307, Issue 1, pp. F96-F106, (2014) (PubMed).
: "Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension." in: Journal of the American Society of Nephrology : JASN, Vol. 23, Issue 5, pp. 834-41, (2012) (PubMed).
: "Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria." in: Journal of the American Society of Nephrology : JASN, Vol. 23, Issue 11, pp. 1879-90, (2012) (PubMed).
: "Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells." in: American journal of physiology. Renal physiology, Vol. 295, Issue 4, pp. F1158-65, (2008) (PubMed).
Synonyme und alternative Namen zu SLC12A1
si:ch211-220f12.1 (si:ch211-220f12.1), solute carrier family 12 member 1 (SLC12A1), solute carrier family 12 member 1 (Slc12a1), solute carrier family 12, member 1 (Slc12a1), AI788571, BSC1, D630042G03Rik, DKFZp469A2020, mBSC1, NKCC2, Nkcc2, slc12a1, SLC12A1, urehr3Bezeichner auf Proteinebene für SLC12A1
- FERM domain-containing protein 4A
- Na/K/Cl cotransporter
- solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- solute carrier family 12 member 1-like
- NKCC2A variant A
- Na-K-2Cl cotransporter
- bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
- kidney-specific Na-K-Cl symporter
- solute carrier family 12 member 1
- Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
- Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
- apical Na(2Cl)K cotransporter
- solute carrier family 12, member 1
- BSC1
- bumetanide-sensitive cotransporter type 1
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