SET Domain Containing (Lysine Methyltransferase) 8 Produkte
(SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
Kategorien
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).
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Ausgewählte SET Domain Containing (Lysine Methyltransferase) 8 Kategorien
SET Domain Containing (Lysine Methyltransferase) 8 Antikörper
High quality antibodies with extensive validation data.
SET Domain Containing (Lysine Methyltransferase) 8 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene SET Domain Containing (Lysine Methyltransferase) 8 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, ICC, FACS
Validierungen
- (5)
Kat. Nr.
ABIN7193329
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, FACS
Validierungen
- (5)
Kat. Nr.
ABIN7193414
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IHC (p)
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN387779
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene SET Domain Containing (Lysine Methyltransferase) 8 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6951049
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6232069
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene SET Domain Containing (Lysine Methyltransferase) 8 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7563657
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7554369
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125068
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren SET Domain Containing (Lysine Methyltransferase) 8 Produkten
: "Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8." in: Biochemistry, Vol. 47, Issue 25, pp. 6671-7, (2010) (PubMed).: "Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation." in: PLoS ONE, Vol. 2, Issue 8, pp. e763, (2010) (PubMed).
: "An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 19, pp. 6292-300, (2009) (PubMed).
: "Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19478-88, (2008) (PubMed).
: "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin." in: Molecular cell, Vol. 9, Issue 6, pp. 1201-13, (2002) (PubMed).
: "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase." in: Current biology : CB, Vol. 12, Issue 13, pp. 1086-99, (2002) (PubMed).
Synonyme und alternative Namen zu SET Domain Containing (Lysine Methyltransferase) 8
lysine methyltransferase 5A (KMT5A), lysine methyltransferase 5A (Kmt5a), lysine methyltransferase 5Ab (kmt5ab), lysine methyltransferase 5A S homeolog (kmt5a.S), lysine methyltransferase 5Aa (kmt5aa), 2410195B05Rik, AA617402, AW536475, KMT5A, kmt5a, kmt5a-a, PR-Set7, PR-SET7, Pr-set7, RGD1305893, SET07, SET8, set8a, Setd8, setd8, setd8-a, setd8a, setd8b, wu:fc23f12, wu:fj33f02, zgc:153719, zgc:171649Bezeichner auf Proteinebene für SET Domain Containing (Lysine Methyltransferase) 8
- H4-K20-HMTase SETD8
- H4-K20-specific histone methyltransferase
- H4K20-specific histone methyltransferase splice variant Set8b
- N-lysine methyltransferase SETD8
- PR/SET domain containing protein 8
- PR/SET domain-containing protein 07
- PR/SET07
- SET domain-containing protein 8
- histone-lysine N-methyltransferase SETD8
- lysine N-methyltransferase 5A
- PR-Set7
- SET domain-containing 8
- SET domain containing (lysine methyltransferase) 8b
- SET domain containing 8b
- N-lysine methyltransferase KMT5A
- SET domain containing (lysine methyltransferase) 8
- histone methyltransferase Pr-set7/Set8
- lysine (K)-specific methyltransferase 5A
- Histone-lysine N-methyltransferase KMT5A-A
- Lysine-specific methylase 5A-A
- N-lysine methyltransferase KMT5A-A
- N-lysine methyltransferase SETD8-A
- SET domain-containing protein 8-A
- histone-lysine N-methyltransferase KMT5A-A
- histone-lysine N-methyltransferase SETD8-A
- lysine (K)-specific methyltransferase 5A S homeolog
- lysine-specific methylase 5A-A
- PR/SET domain containing protein 8a
- SET domain containing (lysine methyltransferase) 8a
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