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Separase Produkte

(Extra Spindle Poles Like 1 (ESPL1))

Kategorien

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].

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Ausgewählte Separase Kategorien

Separase Antikörper

High quality antibodies with extensive validation data.

Separase ELISA Kits

Reliable ELISA kits for a wide range of species.

Empfohlene Separase Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, WB, IHC (p)
Validierungen
  • (7)
  • (3)
Kat. Nr. ABIN564183
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation IHC (p), DB
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN389654
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation ELISA, IHC, WB
Validierungen
  • (3)
Kat. Nr. ABIN7238939
Menge 200 μL
Datenblatt Datenblatt

Empfohlene Separase ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1380135
Menge 2 x 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN5592033
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Separase Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1353121
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3121753
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Separase Produkten

Mukherjee, Ge, Zhang, Edwards, Sumazin, Sharan, Rao, Medina, Pati: "MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas." in: Oncogene, Vol. 33, Issue 48, pp. 5511-22, (2014) (PubMed).

Mukherjee, Byrd, Brawley, Bielamowicz, Li, Merchant, Maitra, Sumazin, Fuller, Kew, Sun, Powell, Ahmed, Zhang, Pati: "Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme." in: Journal of neuro-oncology, Vol. 119, Issue 1, pp. 27-35, (2014) (PubMed).

Zhang, Scorsone, Ge, Kaffes, Dobrolecki, Mukherjee, Lewis, Berg, Stephan, Pati: "Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 878-889, (2014) (PubMed).

Haaß, Stehle, Nittka, Giehl, Schrotz-King, Fabarius, Hofmann, Seifarth: "The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib." in: PLoS ONE, Vol. 7, Issue 8, pp. e42863, (2012) (PubMed).

Mukherjee, Ge, Zhang, Huang, Nakamura, Minor, Fofanov, Rao, Herron, Pati: "Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice." in: PLoS ONE, Vol. 6, Issue 7, pp. e22167, (2011) (PubMed).

Panigrahi, Zhang, Mao, Pati: "Calpain-1 cleaves Rad21 to promote sister chromatid separation." in: Molecular and cellular biology, Vol. 31, Issue 21, pp. 4335-47, (2011) (PubMed).

Meyer, Fofanov, Panigrahi, Merchant, Zhang, Pati: "Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 8, pp. 2703-10, (2009) (PubMed).

Kim, Jeon, Ha, Park, Kim, Shin, Lee, Chung, Lee: "Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner." in: Cancer research, Vol. 69, Issue 1, pp. 27-36, (2009) (PubMed).

Sun, Kucej, Fan, Yu, Sun, Zou: "Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner." in: Cell, Vol. 137, Issue 1, pp. 123-32, (2009) (PubMed).

Fujita, Epperly, Zou, Greenberger, Wan: "Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells." in: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5446-55, (2008) (PubMed).

Synonyme und alternative Namen zu Separase

extra spindle pole bodies like 1, separase (ESPL1), extra spindle poles like 1 (espl1), extra spindle pole bodies 1, separase (Espl1), extra spindle pole bodies like 1, separase (Espl1), AL024103, AU045071, Cerp, ESP1, mp:zf637-3-001691, PRCE, SEPA, SSE

Bezeichner auf Proteinebene für Separase

  • caspase-like protein ESPL1
  • extra spindle poles like 1
  • extra spindle poles-like 1 protein
  • separin
  • separin, cysteine protease
  • cds
  • separase
  • cease&desist
  • zf637-3-001691
  • Cut1/ESP1 related protein
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