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anti-Human SOS1 Antikörper:
anti-Mouse (Murine) SOS1 Antikörper:
anti-Rat (Rattus) SOS1 Antikörper:
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Human Monoclonal SOS1 Primary Antibody für IF, ELISA - ABIN2476553
Scita, Tenca, Frittoli, Tocchetti, Innocenti, Giardina, Di Fiore: Signaling from Ras to Rac and beyond: not just a matter of GEFs. in The EMBO journal 2000
We report on a novel pathogenic mutation in the SOS1 gene and a large clinical spectrum in a Noonan syndrome family with ten genetically confirmed affected individuals.
Data indicate dynamic of H-Ras (zeige HRAS Antikörper) functional cycle as controlled by son of sevenless homolog 1 (Sos).
In summary, patients from two families with history of non-syndromic autosomal-dominant HGF (zeige HGF Antikörper) from Malopolska and Mazovia provinces in Poland had not been affected by HGF (zeige HGF Antikörper) type 1, caused by a single-cytosine insertion in exon 21 of the SOS-1 gene.
Mutation scanning of the entire coding sequence of SOS1 gene identified seven intronic variants and one new exonic substitution (c.138G > A). The seven common intronic variants were not considered to be of pathogenic importance. The exonic substitution c.138G > A was found to be absent in 100 ethnically matched normal control chromosomes, not expected to have functional significance based on prediction bioinformatics tool
Grb2-independent interactions are sufficient to retain human SOS on the membrane for many minutes, during which a single SOS molecule could processively activate thousands of Ras molecules.
a computational methodology that overlays any variant database onto the somatic mutations in all cancer exomes identified activating SOS1 mutations associated with Noonan syndrome as significantly altered in melanoma
Data show that a heterozygous son of sevenless homolog 1 (SOS1) gene frameshift mutation (c.3266dup or c.3248dup) was identified in each patient.
The present study provides a first evidence of allelic imbalance of SOS1 and pinpoints this condition as a possible mechanism underlying a different penetrance of some SOS1-mutated alleles in unrelated carriers
In non-apoptotic cells, nuclear EGFR (zeige EGFR Antikörper) induced SOS1 expression by directly binding to the SOS1 promoter.
findings suggest that targeting the Src (zeige SRC Antikörper)/Abl (zeige ABL1 Antikörper)/Sos1/Rac (zeige AKT1 Antikörper) pathway may represent a double-edged sword to control both cancer-invasive capacities and cancer-related inflammation.
a direct mechanistic link between Sos1 and control of intracellular oxidative stress, and demonstrate functional prevalence of Sos1 over Sos2 with regards to cellular proliferation and viability.
The increased activity of the PI3K/AKT (zeige AKT1 Antikörper) pathway led to downregulation of the surface receptor CD62L (zeige SELL Antikörper) in Sos-1/2dKO T cells and a subsequent impairment in T-cell migration.
SUMOylation of Grb2 (zeige GRB2 Antikörper) enhances the ERK (zeige EPHB2 Antikörper) activity by increasing its binding with Sos1.
Data suggest that interactions between Sos1 (Son of Sevenless homolog 1) and Crk (zeige CRK Antikörper) (proto-oncogene (zeige RAB1A Antikörper) proteins c-crk (zeige CRK Antikörper)) involve electrostatic interactions at binding sites.
ROS1 kinase activity and MEK1/2-ERK1/2 signaling regulates epithelial differentiation in the epididymis.
Sos1 has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT (zeige LAT Antikörper), and in guanine nucleotide exchange activity
ezrin also is important for the activity of SOS itself. Ezrin interacts with GDP-Ras and with the Dbl homology (DH)/pleckstrin homology (PH) domains of SOS, bringing GDP-Ras to the proximity of the allosteric site of SOS.
Absolute counts of mature B and T cells in spleen and peripheral blood were unchanged in single-knockout mutants, while significantly reduced in Sos1/2 double-knockout mice.
Study shows that the ability of Sos1/Grb2 to appropriately regulate pluripotency and differentiation factors and to initiate primitive endoderm development requires collective binding of multiple Sos1/Grb2 domains to their protein and phospholipid ligands.
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.
, gingival fibromatosis, hereditary, 1
, guanine nucleotide exchange factor
, son of sevenless homolog 1
, guanine nucleotide releasing factor
, ras guanine exchange factor
, son-of-sevenless 1
, Son of sevenless homolog 1