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Human HGF Protein expressed in Insect Cells - ABIN1589618
Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015
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Rat (Rattus) HGF Protein expressed in Human Cells - ABIN2009606
Comoglio: Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. in EXS 1993
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Human HGF Protein expressed in HEK-293 Cells - ABIN2722630
Ueda, Ito, Shiraishi, Taniguchi, Kayukawa, Nakanishi, Nakamura, Naya, Hongo, Kamoi, Okihara, Kawauchi, Miki: PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model. in Biochimica et biophysica acta 2015
the development and spread of a tumor is impacted by the initiation of a dynamic interaction between tumor-derived growth factors and CAF-derived HGF; show how disruption of the HGF/c-Met axis can reduce tumor invasiveness and growth
MiR-7 was upregulated in MCF-10A cells by hepatocyte growth factor (HGF), and subsequently downregulated upon treatment with siRNA against HGF. HGF expression did not significantly change through either an upregulation or downregulation of miR-7 expression, suggesting that HGF acts upstream of miR-7. Results indicate that miR-7 mediates the activity of HGF to suppress oncogenic proteins.
our study proved that paeoniflorin could inhibit migration and invasion and actin cytoskeleton rearrangement through inhibition of HGF/c-Met/RhoA/ROCK signaling in glioblastoma, suggesting that paeoniflorin might be a candidate compound to treat glioblastoma.
These results demonstrated hHGF gene transfer induced further overexpression of endogenous rHGF and c-Met mRNAs but lowered immunoreactivities of rHGF and c-Met in the neointima, thus leading to significant attenuation of neointimal hyperplasia.
MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
HGF/c-met signaling is tightly regulated by a negative feedback loop through an ubiquitin-proteasomal degradation pathway.
FAP and HGF play an important role in colorectal cancer (CRC) angiogenesis, and their expression levels are valuable to predict CRC liver metastasis and lymph node metastasis.
These results shed new light in the modality of HGF-dependent c-Src recruitment, and put the basis for novel investigations on the relationship between c-Src, and Testicular Germ Cell Tumours aggressiveness
Study shows that, in the tumor microenvironment, stromal cells activate c-MET through HGF release. Also, the involvement of HGF/MET pathway has been observed in many types of cancer and has been correlated with poor survival. No only HGF leads to enhanced survival of CLL cells but also drives monocytes/macrophages toward an alternative M2 suppressor phenotype, thus facilitating tumor evasion from immune control. [review]
human albumin-expressing ASC-C were observed in the livers of recipient animals. High levels of expression of HGF and its downstream signaling molecules, including p-38, were detected in the ASC-C-injected livers.
BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway.
PCK-HGF-X7 attenuates nerve injury-induced neuropathic pain.
The findings uncovered a critical HGF-dependent signaling pathway that involves the assembly of a large protein complex consisting of MET, AXL, ELMO2, and DOCK180 on the plasma membrane, leading to RAC1-dependent cell migration and invasion in various cancer cells.
Study results revealed a previously uncharacterized role of miRNA200a in regulating tumor malignancy and radiosensitivity of nonsmall cell lung cancer cells by suppressing HGF expression, a key factor in the HGF/cMet pathway.
MUC20 knockdown suppresses the malignant phenotypes of PDAC cells at least partially through the inhibition of the HGF/MET pathway.
High HGF expression is associated with Angiogenesis and Metastasis of Gastric Cancer.
These studies have established the significance of WNT4/WNT11 as well as ITGA2/ITGAV during HGF-mediated migration of HTR-8/SVneo trophoblastic cells.
There was correlation between turbidity toxin intrinsic syndrome of Chronic Erosive Gastritis patients and the expression level of HGF and c-Met.
Hepatocyte growth factor (HGF) levels could determine the relationship of hemoglobin concentration with handgrip strength in elderly Japanese men aged 60-69 years.
While novel diagnostic tumour markers are urgently needed, the examined potential tumour markers, with the exception of PIVKAII seem to be inadequate for diagnosing HCC in ALC \
Arf6 expressed in skin keratinocytes through the HGF/c-Met signaling pathway in response to skin wounding plays an important role in skin wound healing by regulating membrane dynamics-based motogenic cellular function of keratinocytes.
It can be assumed that Sema3a synthesized in the thymus stroma can act as a functional antagonist of HGF and KGF and have an inhibitory effect when these growth factors are administered into the body for the therapeutic purpose of restoring thymus functions.
Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate.
c-Fos is necessary for HGF-mediated gene regulation and cell migration in Schwann cells.
CBD-HGF combined with hydrogel scaffold may be promising for the treatment of serious SCI.
these results suggested that HGF may exert beneficial effects on type II diabetesinduced chronic renal failure via regulation of the NFkappaB signaling pathway.
HGF is beneficial for bone regeneration via increased expression of BMP-2, which leads to neovascularization and bone regeneration through regulation of the NF-kappaB signaling pathway.
these findings highlight the relevance of cross-species protein interactions between murine feeder cells and human epithelial cells in 3T3-J2 co-culture and demonstrate that STAT6 phosphorylation occurs in response to MET activation in epithelial cells. However, STAT6 nuclear translocation does not occur in response to HGF, precluding the transcriptional activity of STAT6.
prolonged treatment of single HGF/c-Met or Hh inhibitor leads to resistance to these single inhibitors, likely because the single c-Met treatment leads to enhanced expression of Shh, and vice versa. Targeting both the HGF/c-Met and Hh pathways simultaneously overcame the resistance to the single-inhibitor treatment and led to a more potent antitumor effect in combination with the chemotherapy treatment.
These results indicate that expression and production of HGF are regulated in a species-specific adipogenic differentiation-dependent manner and suggest that the decrease in HGF mRNA in mouse differentiated adipocytes is, at least in part, mediated by differentiation-dependent loss of its stability.
Mesenchymal stem cells microvesicles stabilization of endothelial barrier function is partly mediated by hepatocyte growth factor.
HGF supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha; and Artemin acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3/Syndecan-3 activation.
Study used biochemical and morphological analyses to demonstrate that two discrete intracellular signaling pathways underlie distinct HGF-induced biological outcomes in developing neocortical neurons. Further, it identified a key developmental epoch, corresponding to the period of dendritic outgrowth and synaptogenesis, during which HGF stimulation elicits maximal activation of MET in the neocortex.
Our results show that BMF-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.
this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis
HGF displays an antioxidant response by inducing the glutathione-related protection system.
this study revealed that HB-EGF as well as HGF inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.
The results suggest that PGRN may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.
Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 receptors or the hepatocyte growth factor (HGF) receptor c-Met (PHA-665752), reversed EMT inhibition by the conditioned medium
Notch signaling plays an important role in regulation of interactions between TGF-beta and HGF signaling pathways in proximal tubule epithelial cells
Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.
SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.
Treatment of the bovine satellite cells (BSC) with ephrin-A5 causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC with hepatocyte growth factor had no immediate effect on cell motility or migration.
HGF transiently increases gene transcription of angiotensin-converting enzyme
acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
the truncated variant of gHGF (a double mutant of N-terminal hairpin and first kringle domains of gHGF, K132E and G134E, gmNK1) protein fused with His6 tag, the molecular weight of which was about 20.0kDa, which was expressed in Escherichia coli BL21 (DE3) and purified with Ni(2+)-affinity chromatography.gmNK1 inhibited protein expression levels of fibrosis-related Col I and alpha-SMA in TGF-beta1-activated HSC-T6 cells
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
fibroblast-derived tumor cytotoxic factor
, hepatocyte growth factor
, lung fibroblast-derived mitogen
, scatter factor
, hepapoietin A
, HGF alpha-chain
, hepatocyte growth factor /scatter factor