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Human HGF Protein expressed in Insect Cells - ABIN1589618
Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015
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Rat (Rattus) HGF Protein expressed in Human Cells - ABIN2009606
Comoglio: Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. in EXS 1993
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Human HGF Protein expressed in HEK-293 Cells - ABIN2722630
Ueda, Ito, Shiraishi, Taniguchi, Kayukawa, Nakanishi, Nakamura, Naya, Hongo, Kamoi, Okihara, Kawauchi, Miki: PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model. in Biochimica et biophysica acta 2015
a higher HGF serum level during hemodialysis treatment is associated with a slower loss of residual renal function
prolonged treatment of single HGF/c-Met or Hh inhibitor leads to resistance to these single inhibitors, likely because the single c-Met treatment leads to enhanced expression of Shh (zeige SHH Proteine), and vice versa. Targeting both the HGF/c-Met and Hh pathways simultaneously overcame the resistance to the single-inhibitor treatment and led to a more potent antitumor effect in combination with the chemotherapy treatment.
TGF-beta (zeige TGFB1 Proteine) negatively controls the HGF/c-MET pathway by regulating of stemness in glioblastoma.
Reduction of fibroblast size upregulates HGF expression, which in turn contributes to loss of collagen, a prominent feature of aged skin.
Results of our present study suggest that both IL-6 and HGF derived from Cancer-associated fibroblasts (CAFs)could contribute to the intratumoral androgen metabolism in ER-negative breast carcinoma patients.
Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease. Review.
this study shows that decidual NK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C (zeige VEGFC Proteine) and HGF
We identify HGF, acting through the c-Met receptor, as the key polarity-inducing morphogen (zeige SHH Proteine), which acts to activate b1-integrin-dependent adhesion. HGF and ECM (zeige MMRN1 Proteine)-derived integrin signals co-operate via a c-Src (zeige SRC Proteine)-dependent inhibition of the RhoA (zeige RHOA Proteine)-ROCK1 (zeige ROCK1 Proteine) signalling pathway via p190A (zeige GRLF1 Proteine) RhoGAP (zeige ARHGAP1 Proteine).
High glucose activated Met receptor in HK2 (zeige HK2 Proteine) cells independently of HGF, via induction of integrin a5b1 and downstream signaling. This mode of Met activation was associated with tubular cell damage and apoptosis and it may represent a novel pathogenic mechanism and a treatment target in diabetic nephropathy.
results show that HGF was involved in regulating Chk1 (zeige CHEK1 Proteine) phosphorylation, and further demonstrate that AKT (zeige AKT1 Proteine) activity was responsible for this HGF-induced Chk1 (zeige CHEK1 Proteine) phosphorylation.
HGF is beneficial for bone regeneration via increased expression of BMP-2 (zeige BMP2 Proteine), which leads to neovascularization and bone regeneration through regulation of the NF-kappaB (zeige NFKB1 Proteine) signaling pathway.
these findings highlight the relevance of cross-species protein interactions between murine feeder cells and human epithelial cells in 3T3-J2 co-culture and demonstrate that STAT6 (zeige STAT6 Proteine) phosphorylation occurs in response to MET activation in epithelial cells. However, STAT6 (zeige STAT6 Proteine) nuclear translocation does not occur in response to HGF, precluding the transcriptional activity of STAT6 (zeige STAT6 Proteine).
These results indicate that expression and production of HGF are regulated in a species-specific adipogenic differentiation-dependent manner and suggest that the decrease in HGF mRNA in mouse differentiated adipocytes is, at least in part, mediated by differentiation-dependent loss of its stability.
Mesenchymal stem cells microvesicles stabilization of endothelial barrier function is partly mediated by hepatocyte growth factor.
HGF supports hindlimb motor neurons through c-Met; CNTF (zeige CNTF Proteine) supports subsets of axial motor neurons through CNTFRalpha (zeige CNTFR Proteine); and Artemin (zeige ARTN Proteine) acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3 (zeige GFRA3 Proteine)/Syndecan-3 (zeige SDC3 Proteine) activation.
Study used biochemical and morphological analyses to demonstrate that two discrete intracellular signaling pathways underlie distinct HGF-induced biological outcomes in developing neocortical neurons. Further, it identified a key developmental epoch, corresponding to the period of dendritic outgrowth and synaptogenesis, during which HGF stimulation elicits maximal activation of MET in the neocortex.
Our results show that BMF (zeige BMF Proteine)-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.
this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis
HGF displays an antioxidant response by inducing the glutathione-related protection system.
Results confirm the prodevelopmental actions of activin A (zeige INHBA Proteine) and indicate that CTGF (zeige CTGF Proteine) may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.
SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.
Treatment of the bovine satellite cells (BSC (zeige SLC12A2 Proteine)) with ephrin-A5 (zeige EFNA5 Proteine) causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC (zeige SLC12A2 Proteine) with hepatocyte growth factor had no immediate effect on cell motility or migration.
HGF transiently increases gene transcription of angiotensin-converting enzyme (zeige ACE Proteine)
acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver
Combined administration of mesenchymal stem cells overexpressing IGF-1 (zeige IGF1 Proteine) and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1 (zeige IGF1 Proteine)/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
the truncated variant of gHGF (a double mutant of N-terminal hairpin and first kringle domains of gHGF, K132E and G134E, gmNK1) protein fused (zeige AXIN1 Proteine) with His6 tag, the molecular weight of which was about 20.0kDa, which was expressed in Escherichia coli BL21 (DE3) and purified with Ni(2 (zeige VMP1 Proteine)+)-affinity chromatography.gmNK1 inhibited protein expression levels of fibrosis-related Col (zeige HDAC1 Proteine) I and alpha-SMA (zeige SMN1 Proteine) in TGF-beta1 (zeige TGFB1 Proteine)-activated HSC (zeige FUT1 Proteine)-T6 cells
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
fibroblast-derived tumor cytotoxic factor
, hepatocyte growth factor
, lung fibroblast-derived mitogen
, scatter factor
, hepapoietin A
, HGF alpha-chain
, hepatocyte growth factor /scatter factor