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Human HGF Protein expressed in Insect Cells - ABIN1589618
Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015
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Human HGF Protein expressed in HEK-293 Cells - ABIN2722630
Ueda, Ito, Shiraishi, Taniguchi, Kayukawa, Nakanishi, Nakamura, Naya, Hongo, Kamoi, Okihara, Kawauchi, Miki: PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model. in Biochimica et biophysica acta 2015
Rat (Rattus) HGF Protein expressed in Human Cells - ABIN2009606
Comoglio: Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. in EXS 1993
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Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease. Review.
this study shows that decidual NK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C (zeige VEGFC Proteine) and HGF
We identify HGF, acting through the c-Met receptor, as the key polarity-inducing morphogen (zeige SHH Proteine), which acts to activate b1-integrin-dependent adhesion. HGF and ECM (zeige MMRN1 Proteine)-derived integrin signals co-operate via a c-Src (zeige SRC Proteine)-dependent inhibition of the RhoA (zeige RHOA Proteine)-ROCK1 (zeige ROCK1 Proteine) signalling pathway via p190A (zeige GRLF1 Proteine) RhoGAP (zeige ARHGAP1 Proteine).
High glucose activated Met receptor in HK2 (zeige HK2 Proteine) cells independently of HGF, via induction of integrin a5b1 and downstream signaling. This mode of Met activation was associated with tubular cell damage and apoptosis and it may represent a novel pathogenic mechanism and a treatment target in diabetic nephropathy.
results show that HGF was involved in regulating Chk1 (zeige CHEK1 Proteine) phosphorylation, and further demonstrate that AKT (zeige AKT1 Proteine) activity was responsible for this HGF-induced Chk1 (zeige CHEK1 Proteine) phosphorylation.
Lymph node metastasis is strongly associated with expression status of HGF and CD133 at the deep invasive front, suggesting the usefulness of these proteins as independent predictive markers of lymph node metastasis in early gastric cancer.
EGF (zeige EGF Proteine)-mediated lysosome trafficking, protease secretion, and invasion is regulated by the activity of p38 mitogen activated protein kinase (zeige MAPK14 Proteine) (MAPK (zeige MAPK1 Proteine)) and sodium hydrogen exchangers (NHEs). Interestingly, EGF (zeige EGF Proteine) stimulates anterograde lysosome trafficking through a different mechanism than previously reported for HGF, suggesting that there are redundant signaling pathways that control lysosome positioning
HGF/c-MET pathway mediates VEGFR (zeige KDR Proteine) inhibitor resistance and vascular remodeling in NSCLC.
We also propose that full-length HGF and HGF-NK1 convey desirable wound healing properties, whilst fibroblasts preferentially expressing more HGF-NK2 readily undergo TGF-beta (zeige TGFB1 Proteine)-driven differentiation into myofibroblasts.
In conclusion, these findings indicate that CMs (zeige Cd2ap Proteine) derived from primary culture of NPC (zeige NPC1 Proteine) fractions of BA liver contain a large amount of active HGF, which may activate hepatic stem/progenitor cells and promote the appearance of hepatocyte-like cells or their clusters through HGF/c-Met signaling.
Mesenchymal stem cells microvesicles stabilization of endothelial barrier function is partly mediated by hepatocyte growth factor.
HGF supports hindlimb motor neurons through c-Met; CNTF (zeige CNTF Proteine) supports subsets of axial motor neurons through CNTFRalpha (zeige CNTFR Proteine); and Artemin (zeige ARTN Proteine) acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3 (zeige GFRA3 Proteine)/Syndecan-3 (zeige SDC3 Proteine) activation.
Study used biochemical and morphological analyses to demonstrate that two discrete intracellular signaling pathways underlie distinct HGF-induced biological outcomes in developing neocortical neurons. Further, it identified a key developmental epoch, corresponding to the period of dendritic outgrowth and synaptogenesis, during which HGF stimulation elicits maximal activation of MET in the neocortex.
Our results show that BMF (zeige BMF Proteine)-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.
this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis
HGF displays an antioxidant response by inducing the glutathione-related protection system.
this study revealed that HB-EGF (zeige HBEGF Proteine) as well as HGF inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.
The results suggest that PGRN (zeige GRN Proteine) may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.
Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA (zeige RHOA Proteine) and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 (zeige PTGDS Proteine) receptors or the hepatocyte growth factor (HGF) receptor c-Met (PHA (zeige LBR Proteine)-665752), reversed EMT (zeige ITK Proteine) inhibition by the conditioned medium
Notch (zeige NOTCH1 Proteine) signaling plays an important role in regulation of interactions between TGF-beta (zeige TGFB1 Proteine) and HGF signaling pathways in proximal tubule epithelial cells
SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.
Treatment of the bovine satellite cells (BSC (zeige SLC12A2 Proteine)) with ephrin-A5 (zeige EFNA5 Proteine) causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC (zeige SLC12A2 Proteine) with hepatocyte growth factor had no immediate effect on cell motility or migration.
HGF transiently increases gene transcription of angiotensin-converting enzyme (zeige ACE Proteine)
acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver
Combined administration of mesenchymal stem cells overexpressing IGF-1 (zeige IGF1 Proteine) and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1 (zeige IGF1 Proteine)/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
fibroblast-derived tumor cytotoxic factor
, hepatocyte growth factor
, lung fibroblast-derived mitogen
, scatter factor
, hepapoietin A
, HGF alpha-chain
, hepatocyte growth factor /scatter factor