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Human HGF Protein expressed in Insect Cells - ABIN1589618
Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015
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Rat (Rattus) HGF Protein expressed in Human Cells - ABIN2009606
Comoglio: Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. in EXS 1993
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Human HGF Protein expressed in HEK-293 Cells - ABIN2722630
Ueda, Ito, Shiraishi, Taniguchi, Kayukawa, Nakanishi, Nakamura, Naya, Hongo, Kamoi, Okihara, Kawauchi, Miki: PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model. in Biochimica et biophysica acta 2015
Met has a role in promoting formation of double minute chromosomes induced by Sei-1 (zeige SERTAD1 Proteine) in NIH-3T3 murine fibroblasts
Genetic activation of the antioxidant transcription factor Nrf2 improves liver damage and repair in hepatocyte-specific c-met-deficient mice mainly through restoring a balance in the cellular redox homeostasis.
MET promoted the development of squamous tumors by stimulating the synthesis and release of ligands that activate the epidermal growth factor receptor (EGFR (zeige EGFR Proteine)).
through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers.
Results show that c-MET expression is significantly low in pancreatic neuroendocrine tumors (PNETs) and is under the regulation of Meg3-mediated transcriptional and epigenetic mechanisms which contributes to the pathogenesis of PNETs.
Findings indicate a role for the hepatocyte growth factor receptor HGFR/c-MET pathway in neutrophil recruitment and function and suggest that c-MET inhibitor co-treatment may improve responses to cancer immunotherapy in settings beyond c-MET-dependent tumors.
Results demonstrate a new mechanism for the modulation of synapse formation, whereby MET activation induces an alignment of presynaptic and postsynaptic elements that are necessary for assembly and formation of functional synapses by subsets of neocortical neurons that express MET/beta-catenin (zeige CTNNB1 Proteine) complex.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 (zeige CD44 Proteine) isoform CD44v4-10.
a c-Met/ETS-1 (zeige ETS1 Proteine)/matrix metalloproteinase-14 (MMP-14 (zeige MMP14 Proteine)) axis that controls VE-cadherin (zeige CDH5 Proteine) degradation, endothelial mesenchymal transition, and vascular abnormality.
Our results show that BMF (zeige BMF Proteine)-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.
In conclusion, these findings indicate that CMs (zeige Cd2ap Proteine) derived from primary culture of NPC (zeige NPC1 Proteine) fractions of BA liver contain a large amount of active HGF, which may activate hepatic stem/progenitor cells and promote the appearance of hepatocyte-like cells or their clusters through HGF/c-Met signaling.
Oxidative stress contributes to HGF-dependent pro-senescence activity of ovarian cancer cells.
These results hold promise that dual targeting of HGF and MET by combining extracellular ligand inhibitors with intracellular MET TKIs could be an effective intervention strategy for cancer patients who have acquired resistance that is dependent on total MET protein.
cabozantinib suppressed MMP1 (zeige MMP1 Proteine) expression by blocking HGF-MET signaling and that HGF-MET-MMP1 (zeige MMP1 Proteine) signaling is involved in the invasiveness and proliferation of BCa (zeige BLNK Proteine) cells. These results suggest that cabozantinib might prove useful for future treatment of muscle-invasive BCa (zeige BLNK Proteine).
The results suggested that HGF may inhibit TEMT (zeige INMT Proteine) by inhibiting AngII through the JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) signaling pathway in HK2 (zeige HK2 Proteine) cells and HGF may prevent apoptosis induced by AngII. The present study provides a basis for understanding the mechanisms involved in the inhibition of TEMT (zeige INMT Proteine) by HGF, which requires further investigation
The identification of novel small-molecule inhibitors of microtubule polymerization highlights the role of the microtubule cytoskeleton in HGF-induced epithelial scattering.
miRNA-200a expression was inverse correlation with HGF expression in stromal fibroblasts. High miRNA-200a and low HGF expression in stromal fibroblasts may predict a good prognosis in patients with non-small cell lung cancer.
Activation of proHGF by St14 (zeige ST14 Proteine) induces mouse embryonic stem cell differentiation.
Study shows that Met and HGF have a multi-factorial relationship to the biology and outcome of breast cancer, influenced by gene copy number and protein expression, activation status, stromal environment, and cellular localisation.
These results reveal the effect of HGF on the distinct pathways of eosinophil secretory functions and also provide novel insights into the role of HGF in the pathogenesis of allergic inflammation.
acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver
SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.
Treatment of the bovine satellite cells (BSC (zeige SLC12A2 Proteine)) with ephrin-A5 (zeige EFNA5 Proteine) causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC (zeige SLC12A2 Proteine) with hepatocyte growth factor had no immediate effect on cell motility or migration.
HGF transiently increases gene transcription of angiotensin-converting enzyme (zeige ACE Proteine)
Combined administration of mesenchymal stem cells overexpressing IGF-1 (zeige IGF1 Proteine) and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1 (zeige IGF1 Proteine)/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
fibroblast-derived tumor cytotoxic factor
, hepatocyte growth factor
, lung fibroblast-derived mitogen
, scatter factor
, hepapoietin A
, HGF alpha-chain
, hepatocyte growth factor /scatter factor