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HGF Protein (AA 32-494, AA 495-728)

HGF Spezies: Human Wirt: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Produktnummer ABIN2017955
  • Target Alle HGF Proteine anzeigen
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 32-494, AA 495-728
    Spezies
    • 23
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 15
    • 9
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    CHO Cells
    Produktmerkmale
    ED50 < 10 ng/mL, measured in a cell proliferation assay using 4MBr5 cells, corresponding to a specific activity of > 1x10^5 units/mg.
    Alpha chain: AA 32-494, beta chain: AA 495-728
    Reinheit
    > 95 % as analyzed by SDS-PAGE.
    Endotoxin-Niveau
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product HGF Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Lyophilized recombinant humanHepatocyte Growth Factor (HGF) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, human Hepatocyte Growth Factor (HGF) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
    Haltbarkeit
    6 months
  • Target
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Andere Bezeichnung
    Hepatocyte Growth Factor (HGF) (HGF Produkte)
    Synonyme
    DFNB39 Protein, F-TCF Protein, HGFB Protein, HPTA Protein, SF Protein, HGF Protein, C230052L06Rik Protein, HGF/SF Protein, NK1 Protein, NK2 Protein, SF/HGF Protein, hepatocyte growth factor Protein, HGF Protein, Hgf Protein
    Hintergrund
    Hepatocyte Growth Factor (HGF),also known as hepatopoietin-A and scatter factor, is a pleiotropic mitogen belonging to the peptidase S1 family (plasminogen subfamily). It is produced by mesenchymal cells and acts on epithelial cells, endothelial cells and haemopoietic progenitor cells. HGF binds to the proto-oncogenic c-Met receptor to activate a tyrosine kinase signaling cascade. It regulates cell growth, motility and morphogenesis, thus it plays a pivotal role in angiogenesis, tumorogenesis and tissue regeneration.Recombinant human Hepatocyte Growth Factor (rhHGF) is produced in CHO cells and consists of two polypeptide chains (alpha-chain and beta-chain) held by a single disulfide bond resulting in the formation of a biologically active heterodimer. The alpha-chain consists of 463 amino acid residues and four kringle domains. The beta-chain consists of 234 amino acid residues. A fully biologically active molecule, rhHGF has a molecular mass of around 88-90 kDa analyzed by reducing SDS-PAGE.
    Synonyms:
    Molekulargewicht
    88-90 kDa (single chain), 59-61kDa (alpha chain), 30-34kDa (beta chain), observed by reducing SDS-PAGE.
    Pathways
    RTK Signalweg, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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