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anti-Human FGF19 Antikörper:
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Human Monoclonal FGF19 Primary Antibody für ELISA, WB - ABIN523342
Shang, Guo, Honda, Saumoy, Salen, Xu: FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels. in Journal of lipid research 2013
FGF19 is induced by hypoxia/reoxygenation (H/R) - treatment in cardiomyocytes. FGF19 knockdown augments H/R-induced injury. FGF19 overexpression protects cardiomyocytes from H/R-induced injury.
Study shows that FXR is phosphorylated at Y67 by non-receptor tyrosine kinase, Src, in response to postprandial FGF19 which is critical for its nuclear localization and transcriptional regulation of bile acids levels and identifies Src-mediated FXR phosphorylation as a potential therapeutic target and biomarker for bile acids-related enterohepatic diseases.
In children and adolescents with NAFLD, hepatic FXR protein content and plasma FGF19 concentrations were decreased compared.
Study showed that FGF19 amplification is a genetic event in Chinese lung squamous cell carcinoma (LSCC) patients, with a frequency of 37.5%. FGF19 amplified LSCC cells express relatively higher levels of FGF19 mRNA expression, and downregulation of FGF19 expression can induce significant cell killing effects in vitro and in vivo.
FGFR4/FGF19 autocrine signaling mediates the survival of a subset of basal-like breast cancer cells
FGF19 copy number may increase in hepatocellular carcinoma accompanying a complete response to sorafenib treatment
Study demonstrates that elevated FGF19 expression or hyperactivation of FGF19/FGFR4 signaling in hepatocellular carcinoma cells is one of the main mechanisms of sorafenib resistance.
This is the first study to elucidate FGF19/FGFR4 signaling in favor of hepatocellular carcinoma cells developing from fatty liver
High expression of FGF19 is associated with hepatocellular carcinoma.
Findings show that FGF19 provides a cytoprotective role against ER stress by activating a FGFR4-GSK3beta-Nrf2 signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC) management.
Fibroblast growth factor 19 levels in human portal blood are higher than in arterial blood. Fibroblast growth factor 19 is released by the portal-drained viscera under fasted steady state conditions.
Intestinal sensing of highly elevated levels of conjugated bile acids in blood promotes FGF15/FGF19 signaling, reducing hepatic bile acid synthesis and modulating bile acid transporters.
serum FGF19 and FGF21 and hepatic Klotho expression are inversely associated with hepatic damage in children with NAFLD
Administering FGF19, or suitable mimetic, as a pharmacological intervention to increase circulating levels of FGF19 and suppress BA synthesis by inhibiting CYP7A1 gene expression is likely to provide therapeutic benefits for many PBC patients
Amplification of FGF19 was validated in independent LSCC samples. Furthermore, FGF19 stimulated LSCC cell growth in vitro. These data implicate FGF19 as a potential driver gene in LSCC with clinic characteristics as smoking.
FGF19 is able to enhance migration and invasion abilities of gastric cancer cells.
Bile acid and FGF19 levels increased after Roux-en-Y bypass, but not after intensive medial management in type 2 diabetic subjects who achieved similar improvement in glycemic control.
FGF19 correlates with severity of liver disease and can potentially serve as an indicator of chronic cholestatic liver injury.
Study shows that FGF19 can be secreted and promotes ovarian cancer progression such as proliferation and invasion by activating FGFR4.
we suggest that considerable mechanistic differences exist between humans and mice with regard to the nuclear receptors controlling the VitA-FGF15/19 axis.
Fgf19 signaling is critical for embryonic forebrain development through its interaction with hedgehog.
This study reveals an important role for FOXC1 in the direct regulation of the FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye.
Fgf19 is required for zebrafish lens and retina development.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
, fibroblast growth factor 19
, fibroblast growth factor 15