anti-DDR2 (DDR2) Antikörper

Human Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Interaktionspartner

1. Our data indicate that DDR2 is a potent biomarker that can be used as an effective therapeutic target for treating oral squamous cell carcinoma patients with lymph node metastasis.

2. DDR2 localisation is independent of integrin activation and the key DDR2 signalling effector SHC1 (zeige SHC1 Antikörper). Structure-function analysis reveals that DDR2 mutants defective for collagen binding or kinase activity are unable to localise to the cell surface, demonstrating for the first time that both collagen binding and kinase functions are required for spatial localisation of DDR2.

3. report the identification and characterization of a selective, extracellularly acting small molecule inhibitor (WRG-28) of DDR2 that uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. By targeting DDR2, WRG-28 inhibits tumor invasion and migration

4. Our results suggest that a mutation in DDR2 occurs naturally with a frequency of about 2% in Korean lung SCC (zeige CYP11A1 Antikörper) patients. In addition, we showed that each of the novel DDR2 mutations were located in a kinase domain and induced an increase in cell proliferation rate.

5. Overexpression of DDR2 might contribute to tumor progression in lung SQCC. The overexpression of DDR2 could be potential molecular target of lung SQCC.

6. DDR2 overexpression is independently associated with tumor progression and poor survival rates in urothelial carcinoma patients.

7. The DDR2 E655K mutation can play a role in cancer progression.

8. collagen II-activated phosphorylated-DDR2 induces CYR61 (zeige CYR61 Antikörper) through activation of transcription factor activator protein 1 (AP-1 (zeige FOSB Antikörper)). The elevated CYR61 (zeige CYR61 Antikörper), in turn, accelerates MMP1 (zeige MMP1 Antikörper) production via ETS1 (ETS (zeige ETS1 Antikörper) proto-oncogene (zeige RAB1A Antikörper) 1).

9. these data suggest that biological collagen aging could increase tumor cell proliferation by reducing the activation of the key matrix sensor DDR2

10. Female ddr2-deficient mice homozygous for the slie mutation show inefficient spontaneous BC metastasis.

Mouse (Murine) Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Interaktionspartner

1. DDR2 is important for maintenance of osteoblast activity and suppression of marrow adipogenesis in vivo and these actions are related to changes in MAPK (zeige MAPK1 Antikörper)-dependent RUNX2 (zeige RUNX2 Antikörper) and PPARgamma (zeige PPARG Antikörper) phosphorylation.

2. circulating fibroblast precursors expressing DDR2, in an exposure-induced model of pulmonary fibrosis, is reported.

3. This work identifies DDR2 as a potential therapeutic target that controls breast cancer metastases through its action in both tumor cells and tumor-stromal cells at the primary tumor site.

4. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 and matrix metalloproteinase 13 (zeige MMP13 Antikörper).

5. DDR2 mutation can drive lung cancer initiation in vivo and provide a novel mouse model for lung cancer therapeutics studies.

6. Study showed that Nrp1 (zeige NRP1 Antikörper) expression paralleled with that of DDR2 during osteoblast differentiation. Nrp1 (zeige NRP1 Antikörper) assisted the promoting role of DDR2 in osteoblast differentiation, via activation of DDR2-mediated downstream signaling.

7. Data show that discoidin domain receptor (DDR (zeige DDR1 Antikörper)) 2 siRNA-mediated suppression of extracellular regulated kinase (ERK) 1 (zeige MAPK3 Antikörper) and 2 and nuclear factor of kappa B (NF-kappaB (zeige NFKB1 Antikörper)) could down-regulate the expressions of matrix metalloproteinase (MMP) 2 (zeige MMP2 Antikörper) and 9.

8. RESULTS Data show that DDR2 (discoidin domain receptor 2) suppresses osteoclast differentiation and activity.

9. DDR2 signaling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing [review]

10. Germline deletion of the DDR2 results in smaller hearts, shorter cardiomyocytes, lower interstitial cardiac collagen density and abnormalities in cardiac function.

Cow (Bovine) Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Interaktionspartner

1. DDR2 activation may be effected by single triple-helices rather than fibrillar collagen