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anti-Human DDR2 Antikörper:
anti-Mouse (Murine) DDR2 Antikörper:
anti-Rat (Rattus) DDR2 Antikörper:
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Human Monoclonal DDR2 Primary Antibody für ICC, IHC - ABIN969083
Leitinger, Kwan: The discoidin domain receptor DDR2 is a receptor for type X collagen. in Matrix biology : journal of the International Society for Matrix Biology 2006
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Human Polyclonal DDR2 Primary Antibody für IF (p), IHC (p) - ABIN755218
Wang, Wang, Zhao, Li, Deng: Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts. in Biochemical pharmacology 2013
Show all 2 Pubmed References
Human Monoclonal DDR2 Primary Antibody für CyTOF, FACS - ABIN4899816
Ali, Ranjbarvaziri, Talkhabi, Zhao, Subat, Hojjat, Kamran, Müller, Volz, Tang, Red-Horse, Ardehali: Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation. in Circulation research 2014
The DDR2 E655K mutation can play a role in cancer progression.
collagen II-activated phosphorylated-DDR2 induces CYR61 (zeige CYR61 Antikörper) through activation of transcription factor activator protein 1 (AP-1 (zeige FOSB Antikörper)). The elevated CYR61 (zeige CYR61 Antikörper), in turn, accelerates MMP1 (zeige MMP1 Antikörper) production via ETS1 (ETS (zeige ETS1 Antikörper) proto-oncogene (zeige RAB1A Antikörper) 1).
these data suggest that biological collagen aging could increase tumor cell proliferation by reducing the activation of the key matrix sensor DDR2
Female ddr2-deficient mice homozygous for the slie mutation show inefficient spontaneous BC metastasis.
This study suggested that DDR1 (zeige DDR1 Antikörper) and DDR2 knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 (zeige TREM2 Antikörper) and microglia.
This work identifies DDR2 as a potential therapeutic target that controls breast cancer metastases through its action in both tumor cells and tumor-stromal cells at the primary tumor site.
The group of patients with colorectal cancer with high DDR2 expression had significantly higher frequencies of T4, lymph node metastasis, and peritoneal dissemination compared to the group with low DDR2 expression.
DDR2 showed high expression in gastric cancer tissues and cells. In xenograft models, DDR2 overexpression promoted tumor formation. Furthermore, DDR2 expression impacted on the invasion and motility of GC cells, accompanied by changes in EMT (zeige ITK Antikörper) marker expression. Finally, our results revealed that DDR2 facilitates GC cell invasion and EMT (zeige ITK Antikörper) through mTORC2 (zeige CRTC2 Antikörper) activation and AKT (zeige AKT1 Antikörper) phosphorylation.
DDR2 mediates collagen-induced activation of MT1-MMP (zeige MMP14 Antikörper) in human fibroblasts
Study strongly suggests that during pulmonary fibrosis, DDR2 not only participates in both the initiation and maintenance of fibrotic reaction, but also affects both ECM (zeige MMRN1 Antikörper) production and angiogenesis.
DDR2 is important for maintenance of osteoblast activity and suppression of marrow adipogenesis in vivo and these actions are related to changes in MAPK (zeige MAPK1 Antikörper)-dependent RUNX2 (zeige RUNX2 Antikörper) and PPARgamma (zeige PPARG Antikörper) phosphorylation.
circulating fibroblast precursors expressing DDR2, in an exposure-induced model of pulmonary fibrosis, is reported.
The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 and matrix metalloproteinase 13 (zeige MMP13 Antikörper).
DDR2 mutation can drive lung cancer initiation in vivo and provide a novel mouse model for lung cancer therapeutics studies.
Study showed that Nrp1 (zeige NRP1 Antikörper) expression paralleled with that of DDR2 during osteoblast differentiation. Nrp1 (zeige NRP1 Antikörper) assisted the promoting role of DDR2 in osteoblast differentiation, via activation of DDR2-mediated downstream signaling.
Data show that discoidin domain receptor (DDR (zeige DDR1 Antikörper)) 2 siRNA-mediated suppression of extracellular regulated kinase (ERK) 1 (zeige MAPK3 Antikörper) and 2 and nuclear factor of kappa B (NF-kappaB (zeige NFKB1 Antikörper)) could down-regulate the expressions of matrix metalloproteinase (MMP) 2 (zeige MMP2 Antikörper) and 9.
RESULTS Data show that DDR2 (discoidin domain receptor 2) suppresses osteoclast differentiation and activity.
DDR2 signaling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing [review]
Germline deletion of the DDR2 results in smaller hearts, shorter cardiomyocytes, lower interstitial cardiac collagen density and abnormalities in cardiac function.
DDR2 activation may be effected by single triple-helices rather than fibrillar collagen
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
CD167 antigen-like family member B
, cell migration-inducing protein 20
, discoidin domain receptor 2
, discoidin domain receptor family, member 2
, discoidin domain-containing receptor 2
, discoidin domain-containing receptor tyrosine kinase 2
, hydroxyaryl-protein kinase
, migration-inducing gene 16 protein
, neurotrophic tyrosine kinase receptor related 3
, neurotrophic tyrosine kinase, receptor-related 3
, receptor protein-tyrosine kinase TKT
, tyrosine-protein kinase TYRO10
, tyrosylprotein kinase
, discoidin domain receptor tyrosine kinase 2
, CD167b antigen
, tyrosine-protein kinase TYRO 10