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These results show that TYRO3 (zeige TYRO3 Proteine), AXL and GAS6 (zeige GAS6 Proteine) are expressed at higher levels in LMS and expression of its ligands correlates to a worse PFS in LMS patients.
miR (zeige MLXIP Proteine)-34a reconstitution in DMPM cells significantly inhibited proliferation and tumorigenicity, induced an apoptotic response, and declined invasion ability, mainly through the down-regulation of c-MET and AXL and the interference with the activation of downstream signaling.
kinase AXL drives the mesenchymal gene signature and motility of ovarian tumor cells.
The AXL inhibitor R428 attenuated RTK and ERK (zeige EPHB2 Proteine) activation and reduced cell motility in Mes (zeige ME1 Proteine) cells in culture and reduced tumor growth
These results highlight the dual role of Axl during Zika virus infection of glial cells: promoting viral entry and modulating innate immune responses.
The expression of AXL was positively associated with GAS6 expression (P < 0.001), and tumor differentiation (P = 0.014) in advanced NSCLC with metastases. AXL expression displayed no association with gender, age, smoking history, pathology, T stage, N stage, CEA, and LDH.
Data indicate a role for AXL receptor tyrosine kinase (AXL) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) and suggest that AXL-mediated SRC (zeige SRC Proteine) family kinases (SFKs) and neuregulin-1 (NRG1 (zeige NRG1 Proteine)) expression promote this process.
Combination of high serum levels of soluble AXL and BNP had greater predictive value for heart failure than BNP alone.
These results demonstrate that Gas6 (zeige GAS6 Proteine)/Axl axis confers aggressiveness in breast cancer.
a lower stability and greater dynamic nature of the Axl kinase domain
These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.
GAS6 (zeige GAS6 Proteine)-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 (zeige NLRP3 Proteine) inflammasome activation.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (zeige ERH Proteine) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
Axl, Mertk (zeige MERTK Proteine) and Tyro3 (zeige TYRO3 Proteine) receptors are not required for Zika virus entry and infection.
Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 (zeige ADAM10 Proteine) and TACE (ADAM17 (zeige ADAM17 Proteine)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (zeige GAS6 Proteine)/Axl and Akt (zeige AKT1 Proteine)/FoxO1a (zeige FOXO1 Proteine) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
activation of receptor tyrosine kinase (zeige RET Proteine) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog