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AXL is the only relevant Zika virus entry cofactor expressed on fetal endothelial cells, and that when produced in mammalian cells, only Zika virus, but not West Nile virus or dengue virus, can use AXL, because it more efficiently binds Gas6 (zeige GAS6 Proteine).
Results indicate AXL receptor tyrosine kinase (AXL) as an important mediator of docetaxel resistance in prostate cancer.
AXL promotes epithelial cell efferocytosis in a tyrosine kinase (zeige TXK Proteine)-dependent manner.AXL role in AKT (zeige AKT1 Proteine)-dependent drug resistance.
The plasma concentrations of Gas6 (zeige GAS6 Proteine) and Axl are lowered in rheumatoid arthritis patients.
The anti-AXL antibody 20G7-D9 represents a promising therapeutic strategy in triple-negative breast cancer with mesenchymal features by inhibiting AXL-dependent Epithelial-Mesenchymal Transition, tumor growth, and metastasis formation
Suppression of AXL by shRNA and inhibitor prolonged survival of chronic myelogenous leukemia (CML) mice and reduced the growth of leukemia stem cells ( LSCs) in mice. Gas6/AXL ligation stabilizes beta-catenin in an AKT-dependent fashion in human CML CD34(+) cells. Our findings improve the understanding of LSC regulation and validate Gas6/AXL as a pair of therapeutic targets to eliminate CML LSCs
our data point to a targetable Axl-PI3 kinase (zeige PIK3CA Proteine)-PD-L1 (zeige CD274 Proteine) axis that is highly associated with radiation resistance
AXL+ and GAS6 (zeige GAS6 Proteine)+ expression is relevant to a poor prognosis in resected lung adenocarcinoma (AD)patients at stage I. AXL/GAS6 (zeige GAS6 Proteine) might serve as crucial predictive and prognostic biomarkers and targets to identify individuals at high risk of post-operative death.
report that Axl regulates FGFR (zeige FGFR2 Proteine) signaling via complex formation with FGFR3 (zeige FGFR3 Proteine)
AZD7762 inhibits the proliferative/metastatic activity of breast cancer cells through the suppression of cellular AXL signaling events including anti-apoptosis, migration, invasion, and angiogenesis.
These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.
GAS6 (zeige GAS6 Proteine)-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 (zeige NLRP3 Proteine) inflammasome activation.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (zeige ERH Proteine) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
Axl, Mertk (zeige MERTK Proteine) and Tyro3 (zeige TYRO3 Proteine) receptors are not required for Zika virus entry and infection.
Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 (zeige ADAM10 Proteine) and TACE (ADAM17 (zeige ADAM17 Proteine)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (zeige GAS6 Proteine)/Axl and Akt (zeige AKT1 Proteine)/FoxO1a (zeige FOXO1 Proteine) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
activation of receptor tyrosine kinase (zeige RET Proteine) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog