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Co-expression of CDCP1 (zeige CDCP1 Proteine) and AXL is often observed in EGFR (zeige EGFR Proteine)-mutation-positive tumors, limiting the efficacy of EGFR (zeige EGFR Proteine) TKIs. Co-treatment with EGFR (zeige EGFR Proteine) TKI and TPX (zeige TPO Proteine)-0005 warrants testing.
This study demonstrates that motility behavior of AXL-expressing tumor cells can be elicited by Gas6 (zeige GAS6 Proteine)-bearing apoptotic bodies generated from tumor treatment with therapeutics that produce killing of a portion of the tumor cells present but not all, hence generating potentially problematic invasive and metastatic behavior of the surviving tumor cells
Results show that average methylation in AXL at birth was associated with higher risk for asthma-related phenotypes in childhood, especially wheezing. The effects of average AXL methylation on wheezing symptoms were magnified in girls compared to boys.
we identified YAP (zeige YAP1 Proteine)-driven AXL overexpression as a mechanism of resistance to EGFR (zeige EGFR Proteine) TKIs in lung cancer cells.
The anti-angiogenic effect of luteolin may be associated with the inhibition of the Gas6 (zeige GAS6 Proteine)/Axl pathway and its downstream phosphatidylinositol 3-kinase (PI3K (zeige PIK3CA Proteine))/protein kinase B (Akt (zeige AKT1 Proteine))/mammalian target of rapamycin (mTOR (zeige FRAP1 Proteine)) signaling pathways.
AXL is influenced by p53 (zeige TP53 Proteine) status and could cause the emergence of aggressive clones after exposure to chemotherapy in colon and breast cancer
Taken together, these findings suggest that AXL most likely serves as an attachment factor for Zika virus on the cell surface, and that productive infection requires endocytosis and delivery of the virus to acidified intracellular compartments.
serum Axl shows high diagnostic accuracy at early stage hepatocellular carcinoma as well as cirrhosis
AXL is the only relevant Zika virus entry cofactor expressed on fetal endothelial cells, and that when produced in mammalian cells, only Zika virus, but not West Nile virus or dengue virus, can use AXL, because it more efficiently binds Gas6 (zeige GAS6 Proteine).
Results indicate AXL receptor tyrosine kinase (AXL) as an important mediator of docetaxel resistance in prostate cancer.
These results suggest a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.
AXL is not the key receptor for Zika virus infection using an Axl knockout mouse model.
present findings indicate that MafB (zeige MAFB Proteine) enhances efferocytosis by regulating Axl expression in RAW264.7 macrophages
Study found that hematopoietic cell-Axl deficiency in Western-type diet-fed Ldlr (zeige LDLR Proteine)(-/-) mice does not affect the progression of advanced atherosclerosis or lesional processes associated with TAM (zeige CCNA1 Proteine) receptor signaling.
This study demonstrated that the Gas6 (zeige GAS6 Proteine)(-/-) Axl(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.
These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.
GAS6 (zeige GAS6 Proteine)-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 (zeige NLRP3 Proteine) inflammasome activation.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (zeige ERH Proteine) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
activation of receptor tyrosine kinase (zeige RET Proteine) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog