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anti-Human SRSF1 Antikörper:
anti-Mouse (Murine) SRSF1 Antikörper:
anti-Rat (Rattus) SRSF1 Antikörper:
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Human Polyclonal SRSF1 Primary Antibody für ICC, IF - ABIN4353084
Brown, Dobrikov, Gromeier et al.: Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated ... in Journal of virology 2014
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Cow (Bovine) Polyclonal SRSF1 Primary Antibody für IHC, WB - ABIN2779013
Velazquez-Dones, Hagopian, Ma, Zhong, Zhou, Ghosh, Fu, Adams: Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. in The Journal of biological chemistry 2005
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A -44 G to A "hot zone" putative functional noncoding variant of SRSF1 was found in an AML (zeige RUNX1 Antikörper) patient. It alters the binding activities of E2F6 (zeige E2F6 Antikörper), ELF1 (zeige EFNA2 Antikörper), and ELK4 (zeige ELK4 Antikörper), ELK4 (zeige ELK4 Antikörper).
We now show that the ability of SRPK1 (zeige SRPK1 Antikörper) to mobilize SRSF1 from speckles to the nucleoplasm is dependent on active CLK1 (zeige CDK11B Antikörper). Diffusion from speckles is promoted by the formation of an SRPK1 (zeige SRPK1 Antikörper)-CLK1 (zeige CDK11B Antikörper) complex that facilitates dissociation of SRSF1 from CLK1 (zeige CDK11B Antikörper) and enhances the phosphorylation of several serine-proline dipeptides in this SR protein (zeige RNPS1 Antikörper)
Authors showed that Mir505-3p was capable of inhibiting tumor proliferation driven by SRSF1 in two neural tumor cell lines, Neuro-2a (N2a) and U251, exclusively in serum-reduced condition. Authors observed that the protein level of SRSF1 was gradually promoted by increasing concentration of serum.
The present study suggested that the tumor suppressor miR30c may be involved in prostate cancer tumorigenesis, possibly via targeting ASF/SF2.
It has been proposed that SF2/ASF has a protective role against JC virus reactivation in multiple sclerosis patients.
Immune suppression of JC virus gene expression is mediated by SRSF1.
ASF/SF2 is identified as a splicing regulator (zeige PTBP2 Antikörper) of cyclin T1 (zeige CCNT1 Antikörper), which contributes to the control of the subsequent transcription events.
Findings suggest MALAT1 increases AKAP-9 (zeige AKAP9 Antikörper) expression by promoting SRPK1 (zeige SRPK1 Antikörper)-catalyzed SRSF1 phosphorylation in CRC (zeige CALR Antikörper) cells. These results reveal a novel molecular mechanism by which MALAT1 regulates AKAP-9 (zeige AKAP9 Antikörper) expression in CRC (zeige CALR Antikörper) cells.
high level of SF2, as a novel oncoprotein in RCC (zeige XRCC1 Antikörper), was significantly associated with poor survival in a large cohort of RCC (zeige XRCC1 Antikörper) specimens. Taken together, our study presents a road map for the prediction and validation of miR (zeige MLXIP Antikörper)-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC (zeige XRCC1 Antikörper) progression.
The authors found that RNA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allosteric mechanism.
In addition, overexpression of SRSF1 in XRCC4 (zeige XRCC4 Antikörper)-deficient cells restored the normal level of apoptosis, suggesting that SRSF1 functions downstream of XRCC4 (zeige XRCC4 Antikörper) in activating CAD (zeige CAD Antikörper).
SRSF1 is a key regulator of DBF4B (zeige DBF4 Antikörper) pre-mRNA splicing dysregulation in colon cancer. SRSF1 is required for cancer cell proliferation.
LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin (zeige CTNNB1 Antikörper) and SRSF1.
This study showed that the splicing factor (zeige SLU7 Antikörper) kinase SRPK1 (zeige SRPK1 Antikörper) is a key regulator of spinal nociceptive processing in naive and nerve injured animals. We present evidence for a novel mechanism in which altered SRSF1 localization/function in neuropathic pain results in sensitization of spinal cord neurons.
The expression levels of three splicing factors, ESRP1 (zeige ESRP1 Antikörper), PTB (zeige PTBP1 Antikörper) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.
RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1
Deletion of RRM1 (zeige RRM1 Antikörper) eliminated the splicing activity of SRSF1 and thus cellular transformation.
Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (zeige SRSF2 Antikörper) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Treatment with IL-17 (zeige IL17A Antikörper) prolongs the half-life of chemokine (zeige CCL1 Antikörper) CXCL1 (zeige CXCL1 Antikörper) mRNA via the adaptor TRAF5 (zeige TRAF5 Antikörper) and the splicing-regulatory factor SF2 (ASF).
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
, SR splicing factor 1
, alternative-splicing factor 1
, pre-mRNA-splicing factor SF2, P33 subunit
, splicing factor 2
, splicing factor, arginine/serine-rich 1
, pre-mRNA-splicing factor SRp30a
, splicing factor, arginine/serine-rich 1 (ASF/SF2)
, splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
, splicing factor, arginine/serine-rich 1B
, splicing factor arginine/serine-rich 1
, serine/arginine-rich splicing factor 1B
, splicing factor, arginine/serine-rich 1b