anti-SRSF1 (SRSF1) Antikörper

Fruit Fly (Drosophila melanogaster) serine/arginine-Rich Splicing Factor 1 (SRSF1) Interaktionspartner

1. DLP (zeige DMD Antikörper) and ASF1 are part of a predeposition complex, which is recruited by XNP (zeige ATRX Antikörper) and is necessary to prevent DNA exposure in the nucleus.

2. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a (zeige ASF1A Antikörper) by TLK (zeige TLK2 Antikörper) kinases.

3. dASF1 has a direct role in modifying chromatin structure during DNA replication and this function of dASF1 is important for the processivity of the replication machinery.

4. Asf1 is directed via interactions with sequence-specific complexes to mediate silencing of specific target genes.

5. Histone chaperones ASF1 and NAP1 (zeige NAP1L1 Antikörper) differentially modulate removal of active histone marks by LID-RPD3 (zeige HDAC1 Antikörper) complexes during NOTCH (zeige NOTCH1 Antikörper) silencing.

Human serine/arginine-Rich Splicing Factor 1 (SRSF1) Interaktionspartner

1. We now show that the ability of SRPK1 (zeige SRPK1 Antikörper) to mobilize SRSF1 from speckles to the nucleoplasm is dependent on active CLK1 (zeige CDK11B Antikörper). Diffusion from speckles is promoted by the formation of an SRPK1 (zeige SRPK1 Antikörper)-CLK1 (zeige CDK11B Antikörper) complex that facilitates dissociation of SRSF1 from CLK1 (zeige CDK11B Antikörper) and enhances the phosphorylation of several serine-proline dipeptides in this SR protein (zeige RNPS1 Antikörper)

2. Authors showed that Mir505-3p was capable of inhibiting tumor proliferation driven by SRSF1 in two neural tumor cell lines, Neuro-2a (N2a) and U251, exclusively in serum-reduced condition. Authors observed that the protein level of SRSF1 was gradually promoted by increasing concentration of serum.

3. The present study suggested that the tumor suppressor miR30c may be involved in prostate cancer tumorigenesis, possibly via targeting ASF/SF2.

4. It has been proposed that SF2/ASF has a protective role against JC virus reactivation in multiple sclerosis patients.

5. Immune suppression of JC virus gene expression is mediated by SRSF1.

6. ASF/SF2 is identified as a splicing regulator (zeige PTBP2 Antikörper) of cyclin T1 (zeige CCNT1 Antikörper), which contributes to the control of the subsequent transcription events.

7. Findings suggest MALAT1 increases AKAP-9 (zeige AKAP9 Antikörper) expression by promoting SRPK1 (zeige SRPK1 Antikörper)-catalyzed SRSF1 phosphorylation in CRC (zeige CALR Antikörper) cells. These results reveal a novel molecular mechanism by which MALAT1 regulates AKAP-9 (zeige AKAP9 Antikörper) expression in CRC (zeige CALR Antikörper) cells.

8. high level of SF2, as a novel oncoprotein in RCC (zeige XRCC1 Antikörper), was significantly associated with poor survival in a large cohort of RCC (zeige XRCC1 Antikörper) specimens. Taken together, our study presents a road map for the prediction and validation of miR (zeige MLXIP Antikörper)-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC (zeige XRCC1 Antikörper) progression.

9. The authors found that RNA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allosteric mechanism.

10. We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 (zeige A2BP1 Antikörper) and SRSF1 complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements

Mouse (Murine) serine/arginine-Rich Splicing Factor 1 (SRSF1) Interaktionspartner

1. SRSF1 is a key regulator of DBF4B (zeige DBF4 Antikörper) pre-mRNA splicing dysregulation in colon cancer. SRSF1 is required for cancer cell proliferation.

2. LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin (zeige CTNNB1 Antikörper) and SRSF1.

3. Authors showed that Mir505-3p was capable of inhibiting tumor proliferation driven by SRSF1 in two neural tumor cell lines, Neuro-2a (N2a) and U251, exclusively in serum-reduced condition. Authors observed that the protein level of SRSF1 was gradually promoted by increasing concentration of serum.

4. This study showed that the splicing factor (zeige SLU7 Antikörper) kinase SRPK1 (zeige SRPK1 Antikörper) is a key regulator of spinal nociceptive processing in naive and nerve injured animals. We present evidence for a novel mechanism in which altered SRSF1 localization/function in neuropathic pain results in sensitization of spinal cord neurons.

5. The expression levels of three splicing factors, ESRP1 (zeige ESRP1 Antikörper), PTB (zeige PTBP1 Antikörper) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.

6. RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1

7. Deletion of RRM1 (zeige RRM1 Antikörper) eliminated the splicing activity of SRSF1 and thus cellular transformation.

8. Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (zeige SRSF2 Antikörper) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.

9. Treatment with IL-17 (zeige IL17A Antikörper) prolongs the half-life of chemokine (zeige CCL1 Antikörper) CXCL1 (zeige CXCL1 Antikörper) mRNA via the adaptor TRAF5 (zeige TRAF5 Antikörper) and the splicing-regulatory factor SF2 (ASF).

10. analysis of the miRNA-mediated interaction between leukemia/lymphoma-related factor (LRF (zeige ZBTB7A Antikörper)) and alternative splicing factor/splicing factor (zeige SLU7 Antikörper) 2 (ASF/SF2) affects cell senescence and apoptosis