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Human Polyclonal PTBP2 Primary Antibody für ELISA, WB - ABIN566177
Rolland, Evrard, Guitton, Lavigne, Calvel, Couvet, Jégou, Pineau: Two-dimensional fluorescence difference gel electrophoresis analysis of spermatogenesis in the rat. in Journal of proteome research 2007
Show all 6 Pubmed References
Human Monoclonal PTBP2 Primary Antibody für ELISA, WB - ABIN566178
Xue, Zhou, Wu, Zhu, Ji, Kwon, Zhang, Yeo, Black, Sun, Fu, Zhang: Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. in Molecular cell 2010
Show all 2 Pubmed References
Human Polyclonal PTBP2 Primary Antibody für ELISA - ABIN262285
Boutz, Stoilov, Li, Lin, Chawla, Ostrow, Shiue, Ares, Black: A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. in Genes & development 2007
Cow (Bovine) Polyclonal PTBP2 Primary Antibody für WB - ABIN2776545
Tateiwa, Gotoh, Ichikawa, Kikuchi, Yoshimura: Molecular cloning and characterization of human PTB-like protein: a possible retinal autoantigen of cancer-associated retinopathy. in Journal of neuroimmunology 2001
the study revealed that PTBP1 (zeige PTBP1 Antikörper) facilitates colorectal cancer migration and invasion activities by inclusion of cortactin (zeige CTTN Antikörper) exon 11
Results showed the expression level of PTBP1 (zeige PTBP1 Antikörper) were increased in bladder cancer (BC) patients and that its expression is negatively regulated by MIR (zeige MLXIP Antikörper)-145.
PTBP1 (zeige PTBP1 Antikörper) is a novel regulator of MCL1 (zeige MCL1 Antikörper) mRNA by which it controls apoptotic response to antitubulin chemotherapeutics.
PTB (zeige PTBP1 Antikörper) interacts specifically with 3'UTR (zeige UTS2R Antikörper) of p53 (zeige TP53 Antikörper) mRNA and positively regulates expression of p53 (zeige TP53 Antikörper) isoforms. PTB (zeige PTBP1 Antikörper) showed some overlapping binding regions in the p53 (zeige TP53 Antikörper) 3'UTR (zeige UTS2R Antikörper) with miR (zeige MLXIP Antikörper)-1285. Knockdown of miR (zeige MLXIP Antikörper)-1285 as well as expression of p53 (zeige TP53 Antikörper) 3'UTR (zeige UTS2R Antikörper) with mutated miR (zeige MLXIP Antikörper)-1285 binding sites resulted in enhanced association of PTB (zeige PTBP1 Antikörper) with the 3'UTR (zeige UTS2R Antikörper), which provides mechanistic insights of this interplay.
It has been established that PTBP1 (zeige PTBP1 Antikörper) and PTBP2 are members of a family of cryptic exon repressors.
These results demonstrate that during early stages of splicing, exon RNP (zeige RNPC3 Antikörper) complexes are highly dynamic with many proteins failing to bind during PTBP1 (zeige PTBP1 Antikörper) arrest.
Studied interactions of polypyrimidine tract-binding protein (zeige PTBP1 Antikörper) (PTBP1 (zeige PTBP1 Antikörper)), pyruvate kinase M2 (PKM2 (zeige PKM2 Antikörper)), and STAT3 (signal transducer and activator of transcription 3 (zeige STAT3 Antikörper)) in oncogenesis of anaplastic large cell lymphoma (ALCL). Results show that in ALCL cells, PTBP1 (zeige PTBP1 Antikörper) is crucial for PKM2 (zeige PKM2 Antikörper) phosphorylation of STAT3 (zeige STAT3 Antikörper) in the nucleus.
Expression of ATG10 (zeige ATG10 Antikörper) negatively regulated by PTBP1 (zeige PTBP1 Antikörper) and is associated with metastasis of colorectal cancer cells.
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm.
follow-up molecular analyses of one splicing factor (zeige SLU7 Antikörper) PTBP1 (zeige PTBP1 Antikörper) revealed its impact on disease-associated splicing patterns in Huntington's disease (HD). Collectively, our data provide genomic evidence for widespread splicing dysregulation in HD brains, and suggest the role of aberrant alternative splicing in the pathogenesis of HD
splicing regulation by Ptbp2 is critical for germ cell communication with Sertoli cells
In round spermatids, MRG15 (zeige MORF4L1 Antikörper) colocalizes with splicing factors PTBP1 (zeige PTBP1 Antikörper) and PTBP2 at H3K36me3 sites between the exons and single intron of transition nuclear protein (zeige HEMGN Antikörper) 2 (Tnp2 (zeige TNP2 Antikörper)). Thus, our results reveal that MRG15 (zeige MORF4L1 Antikörper) is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder
This knockin Ptbp1 (zeige PTBP1 Antikörper) rescued a forebrain-specific, but not a pan (zeige SUPT6H Antikörper)-neuronal, Ptbp2 knockout, demonstrating both redundant and distinct roles for the proteins. Many developmentally regulated exons exhibited different sensitivities to PTBP1 (zeige PTBP1 Antikörper) and PTBP2.
Ptbp2 is an essential factor in heat stress-induced sperm cell injury and non-obstructive azoospermia.
Ptbp2 ablation results in germ cell loss due to increased apoptosis of meiotic spermatocytes and postmeiotic arrest of spermatid differentiation.
These results define a new genetic regulatory program, where PTBP2 acts to temporarily repress expression of adult protein isoforms until the final maturation of the neuron.
Thus, Ptbp2 inhibition of a discrete set of adult neuronal exons underlies early brain development prior to neuronal differentiation and is essential for postnatal survival.
The expression of PSD-95 (zeige DLG4 Antikörper) during early neural development is controlled at the RNA level by two PTB (zeige PTBP1 Antikörper) proteins whose sequential downregulation is necessary for synapse maturation.
The present study provides evidence that alternative neuronal nPTB and Fox-1 (zeige A2BP1 Antikörper)/Fox-2 (zeige RBM9 Antikörper) isoforms are also produced in lenses
Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 (zeige CACNA1C Antikörper) calcium channel transcript by polypyrimidine tract-binding protein (zeige PTBP1 Antikörper).
Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified; deletion of PPT2 results in a complete loss of the IRES activity
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
, neural polypyrimidine tract binding protein
, neural polypyrimidine tract-binding protein
, neurally-enriched homolog of PTB
, polypyrimidine tract-binding protein 2
, splicing regulator
, 57 kDa RNA-binding protein PPTB-1
, RNA-binding protein
, heterogeneous nuclear ribonucleoprotein I
, heterogeneous nuclear ribonucleoprotein polypeptide I
, hnRNP I
, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
, polypyrimidine tract-binding protein 1
, RRM-type RNA-binding protein brPTB
, brain-enriched PTB
, brain-enriched polypyrimidine tract-binding protein
, polypyrimidine tract binding protein 2
, polypyrimidine tract-binding protein 2-like