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Human FAK Protein expressed in HEK-293 Cells - ABIN2720714
Banerjee, de Freitas, Friggeri, Zmijewski, Liu, Abraham: Intracellular HMGB1 negatively regulates efferocytosis. in Journal of immunology (Baltimore, Md. : 1950) 2011
results suggest that W2 suppresses cancer cell migration and invasion by inhibiting FAK/STAT3 (zeige STAT3 Proteine) signaling and STAT3 (zeige STAT3 Proteine) translocation to the nucleus in monomorphic malignant human glioma cells.
these results suggest that Ascochlorin inhibits cell migration and invasion by blocking FAK and JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling, resulting in reduced MMP-2 (zeige MMP2 Proteine) activity.
High levels of phosphorylated tyrosine-397 FAK in the nucleus of patient-derived melanoma tissues.
The RNA-editing enzyme ADAR (zeige ADAR Proteine) promotes lung adenocarcinoma migration and invasion by stabilizing FAK.
The ectopic overexpression of miR-379 inhibited cell migration, invasion and EMT progress, while downregulated miR-379 reversed the effect. In addition, miR-379 regulated the focal adhesion kinase (FAK) by directly binding to its 3'-UTR, resulting in suppression of AKT signaling. In clinical samples of gastric cancer (GC), miR-379 inversely correlated with FAK, which was upregulated in GC.
Building upon previous work suggesting that FAK-Akt1 (zeige AKT1 Proteine) binding is mediated by the FAK F1 lobe, we demonstrated that independently expressing the F1 domain in human Caco-2 or murine CT-26 (zeige DDX53 Proteine) colon cancer cells by transient or stable inducible plasmid expression respectively prevents the stimulation of cancer cell adhesion by increased extracellular pressure.
functional activation of FAK1 in metastases and provide preclinical rationale for targeting this kinase in the setting of advanced ccRCC
this study shows that simultaneous deactivation of FAK and Src (zeige SRC Proteine) improves the pathology of hypertrophic scar
Silencing of p130Cas (zeige BCAR1 Proteine) and inhibition of FAK activity both strongly reduced imatinib and nilotinib stimulated invasion.
IP6K1 (zeige IP6K1 Proteine) physiologically regulates neuronal migration by binding to alpha-actinin (zeige ACTN1 Proteine) and influencing phosphorylation of both FAK and alpha-actinin (zeige ACTN1 Proteine) through its product 5-diphosphoinositol pentakisphosphate.
evidence that despite the fact that FAK is in the active, open conformation at CAs (zeige CSE1L Proteine), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.
FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.
FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.
work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development
These data suggest an important role for the FERM domain in the activation of FAK.
FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (zeige BDNF Proteine), while phosphorylation at Y925 controls the rate of point contact turnover.
Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.
FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.
RhoA (zeige RHOA Proteine) and membrane fluidity mediates the spatially polarized Src (zeige SRC Proteine)/FAK activation in response to shear stress.
XIAP (zeige XIAP Proteine) plays an essential role in shear stress-stimulated FAK phosphorylation.
mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C
These results suggest that TGF-beta1 (zeige TGFB1 Proteine)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (zeige SRC Proteine)-dependent and -independent pathways.
Results suggest focal adhesion kinase is involved in thrombospondin-1 (zeige THBS1 Proteine)-induced vascular smooth muscle cell migration.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Data suggest that focal adhesion kinase (FAK)-SMAD 2/3 mediate signal crosstalk between type II collagen and TGF-beta1 and regulate glycosaminoglycan secretion in chondrocytic cells.
FAK is essentially required in chondrocyte communication with type II collagen (zeige COL2A1 Proteine) by regulating type II collagen (zeige COL2A1 Proteine) expression and cell proliferation.
These findings suggest that NG2 (zeige Vcan Proteine) expression mediates inflammatory reactions and neurodegeneration in microglial cells in response to central nervous system injury, potentially by regulating FAK phosphorylation.
FAK tyrosine 397 autophosphorylation is required for FAK function and is positively regulated by MYO1E (zeige MYO1E Proteine).
The results suggest that FAK is not required for monocyte migration to the perivascular space and that vascular remodeling following arterial occlusion occurs independently of myeloid specific FAK.
These results provide a molecular explanation of how initiation of B cell activation (zeige BLNK Proteine) discriminates substrate stiffness through a PKCbeta-mediated FAK activation dependent manner.
An FAK-YAP (zeige YAP1 Proteine)-mTOR (zeige FRAP1 Proteine) Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.
loss of FAK signaling during endoplasmic reticulum stress causes mitochondrial dysfunction by reducing the protective effects of mitochondrial STAT3 (zeige STAT3 Proteine), leading to endothelial cell death.
Hypoxia activated the focal adhesion kinase (FAK) pathway through upregulation of BNIP3, while FAK inhibition attenuated hypoxic keratinocyte migration.
Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK-dependent regulation of cell migration.
These data support a crucial role for miR (zeige MYLIP Proteine)-27 in promoting chondrogenic differentiation in the pharyngeal arches through regulation of FAK.
findings highlight an essential role of Paxillin (zeige PXN Proteine) and FAK in controlling cardiac contractility via the recruitment of Vinculin (zeige VCL Proteine) to mechano-sensitive sites in cardiomyocytes.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
Focal adhesion kinase (FAK) mediates regulation of growth cone adhesion in the optic tectum of zebrafish.
presynaptic FAK signaling may be disrupted, causing abnormal synaptic growth and transmission in the NF1 (zeige NF1 Proteine) genetic
Fak56 may play a subtle role in the negative regulation of integrin adhesion
Fak56D mutation causes severe disruption of the optic stalk structure. These phenotypes were completely rescued by Fak56D transgene expression in the SG cells but not in photoreceptor cells.
An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup.
Together these findings suggest that modulation of Fak56 function is important for action potential propagation and Ca2 (zeige CA2 Proteine)+-regulated neuromuscular transmission in vivo.
Data show that Fak56 is required to restrict larval neuromuscular junctions (NMJ)growth during NMJ development and mediates an extracellular signal through the integrin receptor.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
, FAK-related non-kinase polypeptide
, PTK2 protein tyrosine kinase 2
, focal adhesion kinase 1
, focal adhesion kinase-related nonkinase
, protein phosphatase 1 regulatory subunit 71
, protein phosphatase 1, regulatory subunit 71
, focal adhesion kinase pp125FAK
, protein-tyrosine kinase 2
, focal adhesion kinase
, focal ashension kinase 1
, protein tyrosine kinase 2.1
, focal adhesion kinase homolog