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Human FAK Protein expressed in HEK-293 Cells - ABIN2720714
Banerjee, de Freitas, Friggeri, Zmijewski, Liu, Abraham: Intracellular HMGB1 negatively regulates efferocytosis. in Journal of immunology (Baltimore, Md. : 1950) 2011
In contrast to mice, the analysis of human olfactory bulbs revealed a late activation of FAK in advanced AAlzheimer's disease stages, whereas ERK1/2 activation was enhanced across AD staging
focal adhesion kinase (FAK) transduces integrin activation and supports Human embryonic stem cell survival, substrate adhesion, and maintenance of the undifferentiated state.
Data show that miR (zeige MLXIP Proteine)-193b, by directly targeting focal adhesion kinase (FAK), CRK (zeige CRK Proteine)-like proto-oncogene (zeige RAB1A Proteine) (CRKL (zeige CRKL Proteine)), and methionine sulfoxide reductase A (MSRA (zeige MSRA Proteine)), regulates focal adhesion signaling and ROS (zeige ROS1 Proteine) signaling, which play pivotal roles in liposarcomagenesis and adipogenic differentiation.
PTK2 inhibition-induced sustained levels of ATG3 (zeige ATG3 Proteine) were able to sensitize cancer cells to DNA-damaging agents.
High FAK expression is associated with Ovarian Cancer.
Generally, this study indicates that miR (zeige MLXIP Proteine)-3173 negatively regulates PTK2 and inhibits proliferation and invasion of B-ALL cell lines. Thus, miR (zeige MLXIP Proteine)-3173 may represent a potential therapeutic molecule for B-ALL intervention.
elevated levels of bile acid increase the tumorigenic potential of pancreatic cancer cells by inducing FXR (zeige NR1H4 Proteine)/FAK/c-Jun (zeige JUN Proteine) axis to upregulate MUC4 (zeige MUC4 Proteine) expression.
Osteoprotegerin (zeige TNFRSF11B Proteine) facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (zeige ITGAV Proteine)/FAK/AKT (zeige AKT1 Proteine) signaling pathway.
the active phosphorylated form of Src (Src (zeige SRC Proteine)(pY416) ) is co-expressed in Exo with phosphorylated FAK (FAK(pY861) ), a known target site of Src (zeige SRC Proteine), which enhances proliferation and migration.
our findings identified FAK as a common aberrant protein overexpression in various subtypes of osteosarcoma. pFAK-Y397 overexpression can be used as a prognostic biomarker predicting poor OS for patients with metastatic osteosarcoma, and the expression of pFAK-Y397 differentiated good and poor responders to neoadjuvant chemotherapy.
evidence that despite the fact that FAK is in the active, open conformation at CAs (zeige CSE1L Proteine), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.
FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.
FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.
work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development
These data suggest an important role for the FERM domain in the activation of FAK.
FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (zeige BDNF Proteine), while phosphorylation at Y925 controls the rate of point contact turnover.
Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.
FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.
RhoA (zeige RHOA Proteine) and membrane fluidity mediates the spatially polarized Src (zeige SRC Proteine)/FAK activation in response to shear stress.
XIAP (zeige XIAP Proteine) plays an essential role in shear stress-stimulated FAK phosphorylation.
mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C
These results suggest that TGF-beta1 (zeige TGFB1 Proteine)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (zeige SRC Proteine)-dependent and -independent pathways.
Results suggest focal adhesion kinase is involved in thrombospondin-1 (zeige THBS1 Proteine)-induced vascular smooth muscle cell migration.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Data suggest that focal adhesion kinase (FAK)-SMAD 2/3 mediate signal crosstalk between type II collagen and TGF-beta1 and regulate glycosaminoglycan secretion in chondrocytic cells.
FAK is essentially required in chondrocyte communication with type II collagen (zeige COL2A1 Proteine) by regulating type II collagen (zeige COL2A1 Proteine) expression and cell proliferation.
In mouse olfactory bulbs, beta-amyloid induced an inactivation of focal adhesion kinase (FAK) together with a transient activation of MEK1/2, leading to inactivation of ERK1/2.
High FAK expression is associated with skin squamous cell carcinoma.
In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c (zeige MEF2C Proteine) through an interaction with the FAK focal adhesion targeting (FAT) domain.
FAK-knockout mice were shorter and showed reduced bone volume. Disruptions of FAK function in osteoblasts reduced mRNA and protein expression of Runx2 (zeige RUNX2 Proteine) Osterix (zeige SP7 Proteine) and collagen-1.
The remodeling of the stromal matrix by CAFs has been shown to increase tumor rigidity to indirectly regulate FAK Y397 phosphorylation in tumor cells to promote their growth and invasion. Accordingly, the Hic-5(-/-);PyMT tumor cells exhibited a reduction in FAK Y397 phosphorylation. Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility
Focal adhesion kinase (FAK) in platelets regulated their migration into the tumor microenvironment, and FAK-deficient platelets completely prevented the rebound tumor growth.
dynamic changes to the extracellular matrix after injury promote fibroblast activation and inhibition of epithelial cell apoptosis in response to TGF-beta (zeige TGFB1 Proteine) through FAK activation.
Results suggest that interleukin-6 (IL-6 (zeige IL6 Proteine)) increases VEGF-C (zeige VEGFC Proteine) induction and lymphangiogenesis may involve, at least in part, Src (zeige SRC Proteine)-FAK-STAT3 (zeige STAT3 Proteine) cascade in lymphatic endothelial cells (LECs).
identify FAK as a novel negative regulator of Beclin1 (zeige BECN1 Proteine)-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth
These data support a crucial role for miR (zeige MYLIP Proteine)-27 in promoting chondrogenic differentiation in the pharyngeal arches through regulation of FAK.
findings highlight an essential role of Paxillin (zeige PXN Proteine) and FAK in controlling cardiac contractility via the recruitment of Vinculin (zeige VCL Proteine) to mechano-sensitive sites in cardiomyocytes.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
Focal adhesion kinase (FAK) mediates regulation of growth cone adhesion in the optic tectum of zebrafish.
presynaptic FAK signaling may be disrupted, causing abnormal synaptic growth and transmission in the NF1 (zeige NF1 Proteine) genetic
Fak56 may play a subtle role in the negative regulation of integrin adhesion
Fak56D mutation causes severe disruption of the optic stalk structure. These phenotypes were completely rescued by Fak56D transgene expression in the SG cells but not in photoreceptor cells.
An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup.
Together these findings suggest that modulation of Fak56 function is important for action potential propagation and Ca2 (zeige CA2 Proteine)+-regulated neuromuscular transmission in vivo.
Data show that Fak56 is required to restrict larval neuromuscular junctions (NMJ)growth during NMJ development and mediates an extracellular signal through the integrin receptor.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
, FAK-related non-kinase polypeptide
, PTK2 protein tyrosine kinase 2
, focal adhesion kinase 1
, focal adhesion kinase-related nonkinase
, protein phosphatase 1 regulatory subunit 71
, protein phosphatase 1, regulatory subunit 71
, focal adhesion kinase pp125FAK
, protein-tyrosine kinase 2
, focal adhesion kinase
, focal ashension kinase 1
, protein tyrosine kinase 2.1
, activated Cdc42 kinase-like
, tyrosine kinase
, focal adhesion kinase homolog