Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human FAK Protein expressed in HEK-293 Cells - ABIN2720714
Banerjee, de Freitas, Friggeri, Zmijewski, Liu, Abraham: Intracellular HMGB1 negatively regulates efferocytosis. in Journal of immunology (Baltimore, Md. : 1950) 2011
The miR-7 (zeige LILRB1 Proteine) can inhibit the activation of ERK/MAPK (zeige MAPK1 Proteine) signaling pathway by down-regulating FAK expression, thereby suppressing the proliferation, migration and invasion of NSCLC cells. The miR-7 (zeige LILRB1 Proteine) and its target gene FAK may be novel targets for the diagnosis and treatment of NSCLC.
Thrombomodulin (TM (zeige THBD Proteine)) promotes angiogenesis by enhancing cell adhesion, migration, and FAK activation through interaction with fibronectin (zeige FN1 Proteine).
FAK activation may facilitate tumour initiation by causing resistance to apoptosis.
Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK-dependent regulation of cell migration.
Our study suggests that FOXM1 (zeige FOXM1 Proteine) transcription factor regulates Integrin b1 gene expression and that FOXM1 (zeige FOXM1 Proteine)/ Integrin-b1/FAK axis may play an important role in the progression of Triple-negative breast cancer
It has been demonstrated that FAK depletion reduces hepatocellular carcinoma cell growth by affecting cancer-promoting genes including the pro-oncogene (zeige RAB1A Proteine) EZH2 (zeige EZH2 Proteine).
High FAK expression is associated with breast cancer cell invasion, transendothelial migration and metastasis.
Study provides evidence that PTK2 expression is regulated by KCNMA1 (zeige KCNMA1 Proteine) in gastric tumorigenesis.
HER2 (zeige ERBB2 Proteine) reduces the radiosensitivity of breast cancer by activating Fak in vitro and in vivo.
The interaction between FAK and tetraspan proteins in physiological and pathological conditions is reviewed.
evidence that despite the fact that FAK is in the active, open conformation at CAs (zeige CSE1L Proteine), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.
FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.
FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.
work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development
These data suggest an important role for the FERM domain in the activation of FAK.
FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (zeige BDNF Proteine), while phosphorylation at Y925 controls the rate of point contact turnover.
Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.
FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.
RhoA (zeige RHOA Proteine) and membrane fluidity mediates the spatially polarized Src (zeige SRC Proteine)/FAK activation in response to shear stress.
XIAP (zeige XIAP Proteine) plays an essential role in shear stress-stimulated FAK phosphorylation.
mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C
These results suggest that TGF-beta1 (zeige TGFB1 Proteine)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (zeige SRC Proteine)-dependent and -independent pathways.
Results suggest focal adhesion kinase is involved in thrombospondin-1 (zeige THBS1 Proteine)-induced vascular smooth muscle cell migration.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Data suggest that focal adhesion kinase (FAK)-SMAD 2/3 mediate signal crosstalk between type II collagen and TGF-beta1 and regulate glycosaminoglycan secretion in chondrocytic cells.
FAK is essentially required in chondrocyte communication with type II collagen (zeige COL2A1 Proteine) by regulating type II collagen (zeige COL2A1 Proteine) expression and cell proliferation.
miR (zeige MLXIP Proteine)-7a was a necessary mediator in FADD (zeige FADD Proteine)-regulated FAK expression. In contrast to its classical apoptotic role, FADD (zeige FADD Proteine) interference could reduce the rate of cell migration, which could be rescued by inhibiting miR (zeige MLXIP Proteine)-7a expression.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
Ablation of Cyclophilin D (zeige PPIF Proteine) Results in an Activation of FAK, Akt (zeige AKT1 Proteine), and ERK (zeige EPHB2 Proteine) Pathways in the Mouse Heart.
FAK loss in calvarial preosteoblasts had no adverse effect on their proliferation and osteogenic differentiation and these cells had intact Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
Ambra1 (zeige AMBRA1 Proteine) binds to both FAK and Src (zeige SRC Proteine) in cancer cells. When FAK is present, Ambra1 (zeige AMBRA1 Proteine) is recruited to focal adhesions, promoting FAK-regulated cancer cell direction-sensing and invasion. However, when Ambra1 (zeige AMBRA1 Proteine) cannot bind to FAK, abnormally high levels of phospho-Src (zeige SRC Proteine) and phospho-FAK accumulate at focal adhesions, positively regulating adhesion and invasive migration.
In mouse olfactory bulbs, beta-amyloid induced an inactivation of focal adhesion kinase (FAK) together with a transient activation of MEK1/2, leading to inactivation of ERK1/2.
Osteoprotegerin (zeige TNFRSF11B Proteine) facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (zeige ITGAV Proteine)/FAK/AKT (zeige AKT1 Proteine) signaling pathway.
High FAK expression is associated with skin squamous cell carcinoma.
These data support a crucial role for miR (zeige MYLIP Proteine)-27 in promoting chondrogenic differentiation in the pharyngeal arches through regulation of FAK.
findings highlight an essential role of Paxillin (zeige PXN Proteine) and FAK in controlling cardiac contractility via the recruitment of Vinculin (zeige VCL Proteine) to mechano-sensitive sites in cardiomyocytes.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
Focal adhesion kinase (FAK) mediates regulation of growth cone adhesion in the optic tectum of zebrafish.
presynaptic FAK signaling may be disrupted, causing abnormal synaptic growth and transmission in the NF1 (zeige NF1 Proteine) genetic
Fak56 may play a subtle role in the negative regulation of integrin adhesion
Fak56D mutation causes severe disruption of the optic stalk structure. These phenotypes were completely rescued by Fak56D transgene expression in the SG cells but not in photoreceptor cells.
An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup.
Together these findings suggest that modulation of Fak56 function is important for action potential propagation and Ca2 (zeige CA2 Proteine)+-regulated neuromuscular transmission in vivo.
Data show that Fak56 is required to restrict larval neuromuscular junctions (NMJ)growth during NMJ development and mediates an extracellular signal through the integrin receptor.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
, FAK-related non-kinase polypeptide
, PTK2 protein tyrosine kinase 2
, focal adhesion kinase 1
, focal adhesion kinase-related nonkinase
, protein phosphatase 1 regulatory subunit 71
, protein phosphatase 1, regulatory subunit 71
, focal adhesion kinase pp125FAK
, protein-tyrosine kinase 2
, focal adhesion kinase
, focal ashension kinase 1
, protein tyrosine kinase 2.1
, activated Cdc42 kinase-like
, tyrosine kinase
, focal adhesion kinase homolog