FAK Proteine (PTK2)

Bezeichnung:
PTK2 Protein tyrosine Kinase 2 Proteine (PTK2)
Auf www.antikoerper-online.de finden Sie aktuell 19 PTK2 Protein tyrosine Kinase 2 (PTK2) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FAK Antikörper (706) und FAK Kits (34) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 786 FAK Produkte verfügbar.
Synonyme:
Fadk, FAK, FAK1, FRNK, mKIAA4203, p125FAK, pp125FAK, PPP1R71
alle Proteine anzeigen Gen GeneID UniProt
PTK2 5747 Q05397
PTK2 25614 O35346
PTK2 14083 P34152

Weitere Synonyme anzeigen

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Am meisten referenzierte FAK Proteine

  1. Human FAK Protein expressed in HEK-293 Cells - ABIN2720714 : Banerjee, de Freitas, Friggeri, Zmijewski, Liu, Abraham: Intracellular HMGB1 negatively regulates efferocytosis. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)

Weitere Proteine zu FAK Interaktionspartnern

Human PTK2 Protein tyrosine Kinase 2 (PTK2) Interaktionspartner

  1. sp(2) -Iminosugar alpha-glucosidase (zeige AGLU Proteine) inhibitor 1 (zeige PPP1R1A Proteine)-C-octyl-2-oxa-3-oxocastanospermine inhibits breast cancer cell migration via beta1-integrin, Stim1 (zeige STIM1 Proteine), and FAK signaling pathways.

  2. results suggest that Kctd20 impacts proliferation and invasion of non-small cell lung cancer through enhancing Fak and Akt (zeige AKT1 Proteine) phosphorylation

  3. mTORC1/2 inhibition promotes reorganization of integrin/focal adhesion kinase-mediated adhesomes, induction of IGFR/IR-dependent PI3K (zeige PIK3CA Proteine) activation, and Akt (zeige AKT1 Proteine) phosphorylation via an integrin/FAK/IGF1R (zeige IGF1R Proteine)-dependent process, mediating tumor drug resistance.

  4. Recruitment of Paxillin (zeige PXN Proteine), Cdc42 (zeige CDC42 Proteine) and N-WASP (zeige WASL Proteine) is necessary for cell adhesion, migration and invasion induced by Estradiol in breast cancer cells.

  5. Type I collagen increased pancreatic ductal adenocarcinoma tumor initiating potential, self-renewal, and the frequency of Cancer stem cells through the activation of FAK.

  6. the administration of 10(-6) M retinoic acid (10-20 min) induces the activation of the migration-related proteins Moesin (zeige MSN Proteine), FAK, and Paxillin (zeige PXN Proteine) in T-47D breast cancer cells.

  7. Study demonstrates that FAK expression, but not kinase activity alone, predominantly mediates thyroid tumor growth and metastasis.

  8. The Pyk2 (zeige PTK2B Proteine)/STAP-2 (zeige STAP2 Proteine) interaction is a novel mechanism to regulate SDF-1alpha-dependent T-cell chemotaxis.

  9. overexpression of syndecan-1 confers to B-LCs an increased capacity to migrate in response to Tat, owing to a switch from a CXCR4/G-protein/Rac to a syndecan-1/alphavbeta3/pp60src/pp125FAK signal transduction pathway that depends on the formation of a complex in which syndecan-1 interacts with Tat via its HS-chains, with alphavbeta3 via its core protein ectodomain and with pp60src via its intracellular tail

  10. MUC5AC interacts with integrin beta4 that mediates phosphorylation of FAK at Y397 leading to lung cancer cell migration.

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) Interaktionspartner

  1. evidence that despite the fact that FAK is in the active, open conformation at CAs (zeige CSE1L Proteine), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.

  2. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  3. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  4. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  5. These data suggest an important role for the FERM domain in the activation of FAK.

  6. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (zeige BDNF Proteine), while phosphorylation at Y925 controls the rate of point contact turnover.

  7. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  8. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) Interaktionspartner

  1. In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c (zeige MEF2C Proteine) through an interaction with the FAK focal adhesion targeting (FAT) domain.

  2. FAK-knockout mice were shorter and showed reduced bone volume. Disruptions of FAK function in osteoblasts reduced mRNA and protein expression of Runx2 (zeige RUNX2 Proteine) Osterix (zeige SP7 Proteine) and collagen-1.

  3. The remodeling of the stromal matrix by CAFs has been shown to increase tumor rigidity to indirectly regulate FAK Y397 phosphorylation in tumor cells to promote their growth and invasion. Accordingly, the Hic-5(-/-);PyMT tumor cells exhibited a reduction in FAK Y397 phosphorylation. Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility

  4. Focal adhesion kinase (FAK) in platelets regulated their migration into the tumor microenvironment, and FAK-deficient platelets completely prevented the rebound tumor growth.

  5. dynamic changes to the extracellular matrix after injury promote fibroblast activation and inhibition of epithelial cell apoptosis in response to TGF-beta (zeige TGFB1 Proteine) through FAK activation.

  6. Results suggest that interleukin-6 (IL-6 (zeige IL6 Proteine)) increases VEGF-C (zeige VEGFC Proteine) induction and lymphangiogenesis may involve, at least in part, Src (zeige SRC Proteine)-FAK-STAT3 (zeige STAT3 Proteine) cascade in lymphatic endothelial cells (LECs).

  7. identify FAK as a novel negative regulator of Beclin1 (zeige BECN1 Proteine)-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth

  8. FAK is tightly associated with H3K9 methylation and negatively related to the growth of tumor-repopulating cells.

  9. FAK plays a key role in regulating macrophage behavior, which underlies the chronic progression of abdominal aortic aneurysms.

  10. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) Interaktionspartner

  1. RhoA (zeige RHOA Proteine) and membrane fluidity mediates the spatially polarized Src (zeige SRC Proteine)/FAK activation in response to shear stress.

  2. XIAP (zeige XIAP Proteine) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C

  4. These results suggest that TGF-beta1 (zeige TGFB1 Proteine)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (zeige SRC Proteine)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (zeige THBS1 Proteine)-induced vascular smooth muscle cell migration.

FAK (PTK2) Protein Überblick

Protein Überblick

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Alternative names and synonyms associated with FAK (PTK2)

  • PTK2 protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (Ptk2)
  • protein tyrosine kinase 2 (ptk2)
  • PTK2 protein tyrosine kinase 2 (Ptk2)
  • Fadk Protein
  • FAK Protein
  • FAK1 Protein
  • FRNK Protein
  • mKIAA4203 Protein
  • p125FAK Protein
  • pp125FAK Protein
  • PPP1R71 Protein

Bezeichner auf Proteinebene für PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

GENE ID SPEZIES
100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
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