FAK Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2720714

Produktdetails

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 1

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FAK Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human FAK1 / PTK2 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Referenzen

Banerjee, de Freitas, Friggeri, Zmijewski, Liu, Abraham: "Intracellular HMGB1 negatively regulates efferocytosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 9, pp. 4686-94, (2011) (PubMed).

Antigendetails

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Andere Bezeichnung: Fak1,ptk2 (PTK2 Produkte)

Synonyme: FADK Protein, FAK Protein, FAK1 Protein, FRNK Protein, PPP1R71 Protein, p125FAK Protein, pp125FAK Protein, PTK2 Protein, Fadk Protein, mKIAA4203 Protein, fak Protein, fak1a Protein, ptk2 Protein, ptk2a Protein, wu:fa18c04 Protein, zgc:66114 Protein, CG10023 Protein, CT28129 Protein, DFAK Protein, DFak Protein, DFak56 Protein, Dfak Protein, Dfak56 Protein, DmFAK Protein, Dmel\\CG10023 Protein, Fak56 Protein, Fak56D Protein, fak56 Protein, protein tyrosine kinase 2 Protein, protein tyrosine kinase 2 L homeolog Protein, PTK2 protein tyrosine kinase 2 Protein, protein tyrosine kinase 2ab Protein, Focal adhesion kinase Protein, PTK2 Protein, ptk2.L Protein, Ptk2 Protein, ptk2ab Protein, Fak Protein

Hintergrund: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined.

Molekulargewicht: 119.1 kDa

NCBI Accession: NP_722560

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling