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anti-Human SP1 Antikörper:
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Human Polyclonal SP1 Primary Antibody für ChIP, WB - ABIN2668968
Wang, Mayhew, Chen, Johnston, Mitra: "Calling cards" for DNA-binding proteins in mammalian cells. in Genetics 2012
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Human Polyclonal SP1 Primary Antibody für ChIP, ICC - ABIN153171
Gui, Song, Han, Zhou, Sheu: Involvement of the GC-rich sequence and specific proteins (Sp1/Sp3) in the basal transcription activity of neurogranin gene. in Biochemical and biophysical research communications 2006
Show all 4 Pubmed References
Human Polyclonal SP1 Primary Antibody für IHC (p), IP - ABIN153172
Lay, Hong, Huang, Yang, Pao, Liu, Lai, Lai, Cheng, Su, Chuang: Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. in Cancer research 2007
Show all 4 Pubmed References
Human Polyclonal SP1 Primary Antibody für IF, IHC - ABIN6712128
Lin, Lai, Chau: Heme oxygenase-1/carbon monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1. in The Journal of biological chemistry 2011
Human Polyclonal SP1 Primary Antibody für WB - ABIN3042489
Zhang, Liu, Liu, Zhou, Song, Cao, An: miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression. in PLoS ONE 2017
Human Polyclonal SP1 Primary Antibody für WB - ABIN537997
Horovitz-Fried, Jacob, Cooper, Sampson: Activation of the nuclear transcription factor SP-1 by insulin rapidly increases the expression of protein kinase C delta in skeletal muscle. in Cellular signalling 2007
Human Polyclonal SP1 Primary Antibody für ELISA, WB - ABIN547479
Sakuntabhai, Turbpaiboon, Casadémont, Chuansumrit, Lowhnoo, Kajaste-Rudnitski, Kalayanarooj, Tangnararatchakit, Tangthawornchaikul, Vasanawathana, Chaiyaratana, Yenchitsomanus, Suriyaphol, Avirutnan et al.: A variant in the CD209 promoter is associated with severity of dengue disease. ... in Nature genetics 2005
Human Polyclonal SP1 Primary Antibody für ELISA, WB - ABIN562963
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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a, sp1 and sod1 in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
our study demonstrates that Sp1 is a major regulator in SRY gene transcription, and mutations of the Sp1 binding sites (Sp1-B and Sp1-C) in the 5' flanking region of SRY induce sex reversal in rabbits
the miR-498 was found to target the 3'-UTR of lncRNA CASC11 and FOXK1 mRNA.
Study found that STC2 is overexpressed in colon adenocarcinoma tissues and positively correlated with poor prognosis. The binding site of the transcription factor Sp1 is widely located in the promoter region of STC2. Knocking down the expression of Sp1 significantly inhibited the transcription activity of STC2.
The authors show that IFI16 restricts HIV-1 independently of immune sensing by binding and inhibiting the host transcription factor Sp1 that drives viral gene expression.
Ajuba functions as a co-activator of SP1 to induce its target gene, and that Ajuba itself is a target genes of SP1. Ajuba/SP1 complex could form a feed forward loop to drive SP1 target gene transcription and promote cell proliferation of pancreatic cancer cells.
Sp1 is a potential prognostic marker and therapeutic target in astrocytoma.
SP1 regulates LHCGR expression and the response of luteal cells to human chorionic gonadotropin.
These data indicated that miR-29b/Sp1/FUT4 axis promoted the malignant behaviors of LSCs by regulating fucosylated CD44 via Wnt/beta-catenin pathway. Identifying LSCs surface markers and targeting LSCs were important for the development of potential therapies in AML.
ETS1 and SP1 regulated DHX15 expression in acute lymphoblastic leukaemia.
Due to the decrease in XYLT1 promoter activity after Sp1 binding site mutation.
The SP-1/miR-135b/HIF-1alpha axis may play a critical role in hypoxia-induced vascular endothelial injury.
SP1 and P300 play an important role during decidualization.
Sp1 and DNMt1 competitively regulate the expression of BACE1 in retinal pigment epithelium cells following photo-oxidation.
Casp3 cleavage of transcription factor Sp1 enhances apoptosis.
These findings suggest that CYP1B1 promotes cancer cell survival through involvement of DNA methylation-mediated DR4 inhibition and that Sp1 may act as key mediator required for oncogenic action.
Data demonstrate that the transcription factor SP1 might be the essential factor in SREBP1a activation by CVB3 2A through MEK/ERK signaling pathway.
Oncogenic HBXIP controls the transcription regulation of ZEB1 by co-activating Sp1, thereby accelerating breast cancer growth.
Sp1-binding sites in the TP promoter were methylated in epidermoid carcinoma. 5-Aza-CdR demethylated Sp1-binding sites and enhanced sensitivity to 5-FU
Specificity protein 1 modulates TGFbeta1/Smad signaling and negatively regulates SIGIRR protein production by macrophages after substance P stimulation.
Sp1 regulates RasGRP1 expression and increases RasGRP1 transcription possibly by binding to its promoter. RasGRP1 expression could be enhanced by Sp1 overexpression, consequently resulting in effects on cell proliferation of HepG2 cells.
Activation of ATM by persistent DNA strand breaks leads to downregulation of transcription factor Sp1 which promotes base excision repair downregulation.
Fatty acid elongase7 expression is regulated via SP1 and is involved in lipid accumulation in bovine mammary epithelial cells.
study demonstrates the co-expression of DLX3, PPARG and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP promoter and its activity.
Study reports that the transcription factor Sp1 controls p11 expression, which impacts on excitability by hampering functional expression of TASK1. In the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS), Sp1-p11-TASK1 dysregulation contributes to increased excitability and vulnerability of motor neurons. Interference with either Sp1 or p11 delays neuron loss and prolongs lifespan in this model.
Mechanistically, SIRT6 binds to the zinc finger DNA binding domain of Sp1 and represses its activity. SIRT6 deficiency increased the occupancy of Sp1 at key mTOR signalling gene promoters resulting in enhanced expression of these genes and activation of the mTOR signalling pathway.
this study identified Sp1 as the critical transcription factor regulating activation of the FST promoter in cav-1 KO MC through binding to a region within 123 bp of the transcription start site.
the results demonstrate the regulatory role of Sp1 in regulation of SN1 expression and activity in ammonia-treated astrocytes and implicate altered Sp1 phosphorylation status in this capacity.
Sp-1 negatively regulates the expression of miR-20b in macrophages.
an immunoprecipitation assay indicated that hypoxia triggered activation of the binding activity of Sp1 to the promoters of PARP-1 and caspase-3, which is abrogated by miR-7a/b. In summary, these findings identified miR-7a/b as protectors of cardiac remodeling and hypoxia-induced injury in H9c2 cardiomyoblasts involving Sp1 and PARP-1.
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta pathways in poly(I:C)-stimulated cells underlies Sp1 phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells
These results suggest that Sp1 regulates gene expression of AACS in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
the results obtained in this study show that Znf179 autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF-induced Sp1 signaling may help attenuate more extensive (ROS-induced) damage following brain injury
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 and Sp1, reducing the level of free Sp1 to inhibit microRNA miR-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 expression in hepatic cells is carried out, in part, by YY1-, Sp1- and Sp3-mediated transcription from the Dp71 promoter.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
miR-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1