SP1 Antikörper (AA 1-250)

Produktnummer ABIN1944791

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-SP1 Antikörper wird verwendet zum Nachweis von SP1 in Proben von Human. Er wurde validiert für WB, IF und FACS.

Kurzübersicht für SP1 Antikörper (AA 1-250) (ABIN1944791)

Target: SP1 (Sp1 Transcription Factor (SP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 1326CT463-109-176

Produktdetails anti-SP1 Antikörper

Bindungsspezifität: AA 1-250

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This SP1 antibody is generated from a mouse immunized with a recombination protein from the human SP1.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:1000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SP1 Antikörper (ABIN1944791)

Takahara, Kanazu, Yanagisawa, Akanuma: "Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing." in: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 38067-72, (2000) (PubMed).

Kadonaga, Carner, Masiarz, Tjian: "Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain." in: Cell, Vol. 51, Issue 6, pp. 1079-90, (1988) (PubMed).

Details zu SP1

Target: SP1 (Sp1 Transcription Factor (SP1))

Andere Bezeichnung: SP1

Hintergrund: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.

Molekulargewicht: 80693

Gen-ID: 6667

UniProt: P08047

Pathways: Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction