Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human P2RX7 Antikörper:
anti-Mouse (Murine) P2RX7 Antikörper:
anti-Rat (Rattus) P2RX7 Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Rat (Rattus) Polyclonal P2RX7 Primary Antibody für WB - ABIN1742370
Young, Brutkowski, Lien, Arkle, Lochmüller, Zabłocki, Górecki: P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment. in Journal of cellular and molecular medicine 2012
Show all 3 Pubmed References
Human Polyclonal P2RX7 Primary Antibody für IF (p), IHC (p) - ABIN1386314
Peng, Liu, Wei, Lv, Wang, Xiong, Wang, Altaf, Wang, He, Wang, Qu: P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation. in International journal of molecular medicine 2015
Show all 2 Pubmed References
Mouse (Murine) Monoclonal P2RX7 Primary Antibody für FACS, IF - ABIN2476002
Norström, Bryman: Adenosine 3',5'-monophosphate in relation to inhibition of cervical smooth muscle activity in early pregnant women. in Acta endocrinologica 1991
Show all 4 Pubmed References
Mouse (Murine) Monoclonal P2RX7 Primary Antibody für FACS - ABIN2476004
Harlan: Standardized brain mapping. in Science (New York, N.Y.) 1991
Show all 4 Pubmed References
Mouse (Murine) Monoclonal P2RX7 Primary Antibody für FACS - ABIN2476005
Adriouch, Dubberke, Diessenbacher, Rassendren, Seman, Haag, Koch-Nolte: Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization. in Cellular immunology 2005
Show all 4 Pubmed References
Mouse (Murine) Monoclonal P2RX7 Primary Antibody für FACS - ABIN2476003
Adriouch, Bannas, Schwarz, Fliegert, Guse, Seman, Haag, Koch-Nolte: ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Show all 4 Pubmed References
Human Polyclonal P2RX7 Primary Antibody für IHC (p), WB - ABIN651861
Kim, Jiang, Wilson, North, Surprenant: Proteomic and functional evidence for a P2X7 receptor signalling complex. in The EMBO journal 2001
Show all 2 Pubmed References
Human Polyclonal P2RX7 Primary Antibody für IHC (p), IHC - ABIN451826
Tomasinsig, Pizzirani, Skerlavaj, Pellegatti, Gulinelli, Tossi, Di Virgilio, Zanetti: The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner. in The Journal of biological chemistry 2008
Human Polyclonal P2RX7 Primary Antibody für IHC, IHC (p) - ABIN4342631
Gilbert, Oliphant, Hassan, Peille, Bronsert, Falzoni, Di Virgilio, McNulty, Lara: ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival. in Oncogene 2019
Dog (Canine) Polyclonal P2RX7 Primary Antibody für EIA, IHC (p) - ABIN5551878
Graziano, Desdouits, Garzetti, Podini, Alfano, Rubartelli, Furlan, Benaroch, Poli: Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages. in Proceedings of the National Academy of Sciences of the United States of America 2015
Blockade of the P2X7 receptor reduces cyst formation via ERK-dependent pathways in a zebrafish model of polycystic kidney disease.
The pattern of responsiveness to more selective P2-antagonists implies that both P2Y13 and P2X7 receptors are involved in Epsilon-toxin-of Clostridium perfringens induced hemolysis in human species.
The effects of P2RX7 variants on bipolar disorder may be sex-specific, with increased P2X7 activity potentially elevating risk for bipolar disorder in females.
that the profile of P2 receptors is shifted in ARPKD cystic epithelia in an age-related manner towards prevalence of P2X4 and/or P2X7 receptors
Here, we demonstrate that P2X7R is associated with a pro-inflammatory phenotype of human microglia in vitro, and is highly expressed in microglia in multiple sclerosis lesions
ATP-activated P2 purinergic receptors (P2X7) receptor is a key player in innate immune response. Study discusses the role of the P2X7 receptor in the pathogenesis and development of mood disorders and in discovering P2X7 antagonists.
the patients carrying GA and AA genotypes of P2RX7 needed more fentanyl to control pain within 48 hours after surgery. P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer.
Meta-analysis found a significant association between rs2230912 and combined mood disorders (major depressive disorder (MDD) or bipolar disorder (BD)) for the allelic, dominant and heterozygous-disadvantage model, all withstanding threshold of correction for multiple testing. Stratifying by disorder revealed significant findings for the MDD-subgroup, while the BD-subgroup presented with lower effect size & no significance
activation of P2RX7 by eATP provides a common currency that both alerts the nervous and immune system to tissue damage, and promotes the metabolic fitness and survival of the most durable and functionally relevant memory CD8(+) T cell populations
Results suggest the pathophysiological role of purinergic receptor P2X7 (P2X7) in pancreatic disease and recovery.
The P2x7 ion channel receptor was regularly absent in both the periodontal ligament and dental tissues
These results suggest that ERK pathway is involved in the proliferation and migration of glioma cells induced by P2X7R activation.
Increased P2X7 receptor expression in monocytes are manifestations of chronic inflammation in the early stages of chronic kidney disease.
the P2X7R rs3751143 and ER-alpha PvuII two-locus interaction confers a significantly high susceptibility to osteoporosis in Chinese postmenopausal women.
that the P2X7R rs3751143 functional polymorphism might contribute to osteoporosis susceptibility in Chinese postmenopausal women
indicating the involvement of P2X7R in the growth of esophageal squamous cell carcinoma
Data show that Pr2x7 gene deletion protects from HFD-induced NASH, possibly through blunted activation of NLRP3 inflammasome.
this study demonstrates that P2X7 is not essential for development of imiquimod -induced psoriasis-like inflammation
This study revealed that the P2X7R/NLRP3 pathway plays important roles in IL-1beta secretion and inhibition of Toxoplasma gondii proliferation in small intestinal epithelial cells.
P2X7R contributes to the progression of spinal TB. The P2X7 -762C>T and 489C>T polymorphisms are correlated with susceptibility to spinal TB. Carrying the -762CC genotype and 489T allele increases the risk of developing spinal TB in a Southern Chinese Han population.
Increased expression of P2X7R in peripheral blood mononuclear cells from patients with rheumatoid arthritis.P2X7R role in th17 cells differentiation.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.
ATP and P2X7 pathway is essential for C. difficile-induced inflammasome activation.
Study concludes that P2X7 receptor knock-out improves the emotional conditions at later stages of the lifespan of mice, but not in all ages, suggesting time-specific roles of immune response in nervous system through NF-kappaB signaling pathway.
This novel mouse model overcomes previous limitations in P2X7 research and will help to determine its physiological roles and contribution to diseases.
this study shows that blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies
The study shows a novel role of leptin-induced P2X7r in modulating Glut4 induction and translocation in hepatic stellate cells, that are key to nonalcoholic steatohepatitis progression.
Results indicate that tet oncogene 1 protein (Tet1) and tet oncogene 2 protein (Tet2) play a critical role in maintaining bone marrow MSCs (BMMSCs) and bone homeostasis through demethylation of P2X7 purinoceptor (P2rX7) to control exosome and miRNA release.
results show that the P2X7 has a key role during inflammation development in inflammatory bowel disease, by triggering the death and retention in the mesenteric lymph nodes of regulatory T cells that would otherwise promote immune system tolerance in the gut.
The treatment of RAW264.7 cells with high glucose and free fatty acids increased the expression of LncRNA uc.48+, which evoked P2X7R-mediated immune and inflammatory responses through several pathways, including cytokine secretion.
Inhibition or knockout of P2X7 receptors attenuated surgery and anesthesia-induced neuroinflammation and cognitive impairment. We conclude that surgery under desflurane anesthesia may have reduced neuroinflammation and cognitive impairment compared with surgery under isoflurane anesthesia. P2X7 receptors may mediate the neuroinflammation and cognitive impairment after surgery.
Data show that Pr2x7 gene deletion protects from HFD-induced NASH, possibly through blunted activation of NLRP3 inflammasome
The results of this study suggested that specific pharmacological or genetic blockade of P2X7R promotes anxiogenic-like effects, along with deficits in extinction learning.
genetic ablation of the P2X7 receptor attenuated the IL-1beta and IL-6 production in the brain from septic mice. Furthermore, our results suggest a crucial role for the enzyme CD39 in limiting P2X7 receptor proinflammatory responses since CD39(-/-) septic mice exhibited higher levels of IL-1beta in the brain.
P2X7R role in th17 cells differentiation.
Studies indicate the role of P2X7R (purinergic 2X7 receptor) and NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome activation in the process of pancreatic fibrosis in chronic pancreatitis (CP) and suggest that blockade of P2X7R-NLRP3 inflammasome signaling pathway may represent a therapeutic strategy for CP and its fibrotic process.
CD39 expression in macrophages limits P2X7-mediated pro-inflammatory responses, scavenging extracellular ATP and ultimately generating adenosine. CD39 genetic deletion exacerbates sepsis-induced experimental liver injury.
P2X7 receptor signaling is involved in neuronal cell death after axonal injury, being P2X7 receptor antagonism a potential therapeutic strategy.
Results show P2xr7-dependent synaptic alterations in the learned helplessness animal model of depression, suggesting a potential structural correlate of the antidepressant effect of genetic deletion of P2rx7.
P2X7 receptor deficient mice (P2rx7-/-), the social interactions were increased, whereas the PCP induced hyperlocomotion and stereotype behavior were alleviated. The selective P2X7 receptor antagonist JNJ-47965567 partly replicated the effect of gene deficiency on PCP-induced behavioral changes and counteracted PCP-induced social withdrawal.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
P2X purinoceptor 7
, purinergic receptor P2X, ligand-gated ion channel, 7
, p2X purinoceptor 7-like
, ATP receptor
, P2X7 receptor
, P2Z receptor
, purinergic receptor P2X7 variant A
, P2X7 purinoceptor
, purinergic receptor P2X7