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PASK phosphorylates and inactivates GSK3beta (zeige GSK3b ELISA Kits), thereby preventing PDX-1 (zeige PDX1 ELISA Kits) serine phosphorylation and alleviating GSK3beta (zeige GSK3b ELISA Kits)-mediated PDX-1 (zeige PDX1 ELISA Kits) protein degradation in pancreatic beta-cells.
Mutations that affect PAS domain cause a severe protein trafficking defect and change the interactions with Kv11.1 (zeige KCNH2 ELISA Kits) channels.
The role of PAS kinase in PASsing the glucose signal.
Per-Arnt (zeige ARNT ELISA Kits)-Sim (zeige SIM2 ELISA Kits) (PAS) domain-containing protein kinase (zeige CDK7 ELISA Kits) (PASK) has a role in insulin (zeige INS ELISA Kits) hypersecretion
PASK is involved in the regulation of glucagon (zeige GCG ELISA Kits) secretion by glucose and may be a useful target for the treatment of type 2 diabetes.
Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.
Results suggest that elevated glucose concentrations rapidly increase Per-Arnt (zeige ARNT ELISA Kits)-Sim (zeige SIM2 ELISA Kits) kinase activity in pancreatic islet beta cells, followed by up-regulation by glucose of preproinsulin (zeige INS ELISA Kits) and pancreatic duodenum homeobox (zeige Lbx1 ELISA Kits) 1 gene expression.
identified the multifunctional eukaryotic translation elongation factor (zeige TSFM ELISA Kits) eEF1A1 (zeige EEF1A1 ELISA Kits) as a novel interaction partner of PASKIN in the nuclei of testis germ cells and in the midpiece of sperm tails
The findings demonstrate cell-autonomous roles for PASK in the control of pancreatic endocrine hormone secretion. Differences between the glycaemic phenotype of global vs cell type-specific null mice suggest important roles for tissue interactions in the control of glycaemia by PASK.
the PAS kinase function could be critical for preserving the nutrient effect on AMP-activated protein kinase (zeige PRKAA2 ELISA Kits) and mammalian target of rapamycin (zeige FRAP1 ELISA Kits)/S6K1 (zeige RPS6KB1 ELISA Kits) pathways and maintain the regulatory role of exendin-4 in food intake
PASK is a key kinase in GLP-1 (zeige GCG ELISA Kits) actions and exerts a coordinated response with the other metabolic sensors.
These data strongly suggest that PASK is required for normal nutrient partitioning and energy homeostasis in the mouse and that this activity is primarily carried out in a cell-autonomous fashion.[Review]
Targeted disruption of the PAS domain serine/threonine kinase was studied.
Paskin gene expression is not induced by glucose in pancreatic beta-cells and glucose-stimulated insulin (zeige INS ELISA Kits) production is independent of PASKIN.
PASK acts in a cell-autonomous manner to maintain cellular energy homeostasis and is a potential therapeutic target for metabolic disease
Suggest that paskin is involved in the central control of hypoxic ventilation, modulating ventilation in a gender-dependent manner.
This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PAS domain-containing serine/threonine-protein kinase
, PAS domain containing serine/threonine kinase
, PAS domain-containing serine/threonine-protein kinase-like
, per-arnt-sim (PAS) domain kinase