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anti-Human RASA1 Antikörper:
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Chicken Monoclonal RASA1 Primary Antibody für IF, IP - ABIN967706
Cichowski, Santiago, Jardim, Johnson, Jacks: Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. in Genes & development 2003
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Cow (Bovine) Monoclonal RASA1 Primary Antibody für ICC, IF - ABIN266005
Muto, Yi, Harrison, Dávalos, Fancher, Ziegler, Feigel, Kondo, Nishibe, Sessa, Dardik: Eph-B4 prevents venous adaptive remodeling in the adult arterial environment. in The Journal of experimental medicine 2011
RASA1 mutations are associated melanoma tumorigenesis.
MicroRNA-21 reduces RASA1 expression in cervical cancer cell lines and promotes cervical cancer cell migration via RASA1. Furthermore, Ras-induced epithelial-mesenchymal transition contributes to miR (zeige MLXIP Antikörper)-21/RASA1 axis promoting cervical cancer cell migration.
These results and the extreme variable expressivity support the hypothesis that somatic "second hits" are required for the development of vascular anomalies associated with CM-AVM syndrome. In addition, the phenotypes of the affected individuals further clarify that lymphatic manifestations are also part of the phenotypic spectrum of RASA1-related disorders.
results indicate that, mTOR (zeige FRAP1 Antikörper), Bad, or Survivin (zeige BIRC5 Antikörper) are not required for p120 RasGAP fragment N to protect cells from cell death; conclude that downstream targets of Akt (zeige AKT1 Antikörper) other than mTORC1, Bad, or survivin (zeige BIRC5 Antikörper) mediate fragment N-induced protection or that several Akt (zeige AKT1 Antikörper) effectors can compensate for each other to induce the pro-survival fragment N-dependent responses
The interaction between RASA1 and EPHB4 (zeige EPHB4 Antikörper) is an indication of the major cause of capillary malformation with arteriovenous malformation.
Low RASA1 expression is associated with Triple-Negative Breast Cancer.
QKI-5 (zeige QKI Antikörper) stabilized RASA1 mRNA via directly binding to the QKI (zeige QKI Antikörper) response element region of RASA1, which in turn prevented the activation of the Ras-MAPK (zeige MAPK1 Antikörper) signaling pathway, suppressed cellular proliferation and induced cell cycle arrest.
Data show that patients with low level of Ras GTPase-activating protein 1 (RASA1) expression correlated with a significantly poorer survival compared to those with high level of RASA1 expression.
Results show that oncogenic KRAS can activate Rho through miR-31-mediated regulation of RASA1 indicating miR-31 acts as a KRAS effector to modulate invasion and migration in pancreatic cancer.
PTP1B (zeige PTPN1 Antikörper) dephosphorylates PITX1 (zeige PITX1 Antikörper) to weaken its protein stability and the transcriptional activity for p120RasGAP gene expression
The data suggest that nitrosylation of H-Ras (zeige HRAS Antikörper) rearranges the adsorptive potential and intrinsic GTPase (zeige RACGAP1 Antikörper) activity of H-Ras (zeige HRAS Antikörper) through modification of C-terminal cysteines of molecule.
RASA1 catalytic activity is essential for the function and development of lymphatic vessel valves.
These results indicate that the caspase-3 (zeige CASP3 Antikörper)/p120 RasGAP stress-sensing module impacts on carcinogen-induced liver cancer incidence but not sufficiently so as to affect overall survival.
Double-deficient RASA1-neurofibromin 1 (zeige NF1 Antikörper) mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 (zeige NOTCH1 Antikörper) gene.
Rasa1 may have a role in pathogenesis of capillary malformation-arteriovenous malformation in a mouse model
Regulation of Rasa1 translation by miR (zeige MLXIP Antikörper)-132 was seen in severed axons, demonstrating local function within the axon.
RASA1 mutation is responsible for the aberrant lymphatic architecture and functional abnormalities, as visualized in the PKWS subject and in the animal model.
MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA by repressing RAS p21 (zeige D4S234E Antikörper) GTPase activating protein 1 (RASA1)
14-3-3 (zeige YWHAQ Antikörper) negatively regulates the RGC downstream of the PI3-kinase (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) signaling pathway
Caspase-3 (zeige CASP3 Antikörper) is a stress intensity sensor that controls cell fate by either initiating a RasGAP cleavage-dependent cell resistance program or a cell suicide response mediated by akt (zeige AKT1 Antikörper).
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
, Ras GTPase-activating protein
, vacuolar peduncule
, vacuolar pedunculi
, ras GTPase-activating protein 1
, triphosphatase-activating protein
, GTPase-activating protein
, RAS p21 protein activator (GTPase activating protein RAS p21)
, RAS p21 protein activator 1