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PSMA Proteine

(Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010].

Häufig verwendete PSMA Proteine

Aliase für PSMA Proteine

putative N-acetylated-alpha-linked acidic dipeptidase (LOC451185) Proteine
folate hydrolase 1B (FOLH1B) Proteine
folate hydrolase 1 (FOLH1) Proteine
folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1) Proteine
folate hydrolase 1 (Folh1) Proteine
FGCP Proteine
FOLH Proteine
GCP2 Proteine
GCPII Proteine
mGCP Proteine
mopsm Proteine
Naalad Proteine
NAALAD1 Proteine
NAALAdase Proteine
PSM Proteine
PSMA Proteine
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