Leptin Protein (LEP)
Kurzübersicht für Leptin Protein (LEP) (ABIN935601)
Target
Alle Leptin (LEP) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Sequenz
- MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC
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Produktmerkmale
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Purified recombinant Human Leptin protein
Expression System: E.coli
Bioactivity: PeproTech's Mouse Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 14 days. Significant effects on body weight, , food consumption, and plasma glucose levels were observed to saline-treated controls -
Endotoxin-Niveau
- < 0.1 ng per µg (1 EU/µg).
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Leptin (LEP) (AA 22-167) protein (Fc Tag)
LEP Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leptin (LEP) proteinLEP Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin (LEP) protein (His tag)LEP Spezies: Goldfisch Wirt: Hefe Recombinant > 95 % as determined by reducing SDS-PAGE.
Leptin (LEP) (AA 22-167) protein (His tag)LEP Spezies: Schwein Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Leptin (LEP) (AA 22-167) protein (His tag)LEP Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Leptin (LEP) (AA 428-635) protein (His tag)LEP Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Leptin (LEP) (AA 22-167) protein (GST tag)LEP Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Leptin (LEP) (AA 22-167) protein (Fc Tag)LEP Spezies: Human Wirt: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Leptin (LEP) proteinLEP Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant 95,00% SDS
Leptin (LEP) (AA 29-164), (partial) protein (GST tag)LEP Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 90 % ELISA
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstitute in water to a concentration of 1.0-5.0 mg/mL.
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Buffer
- Lyophilized from 0.1 % TFA.
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- RT/-20 °C
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- Leptin (LEP)
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Andere Bezeichnung
- Leptin
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Hintergrund
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Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models.
Alternative Names: Obesity protein, OB protein -
Molekulargewicht
- 16.2 kDa
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Pathways
- JAK-STAT Signalweg, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
Target
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