IGFBP4 Protein

Produktnummer ABIN935568

Dieses Recombinant IGFBP4-Protein wird in Hi-5 Cells exprimiert.

Kurzübersicht für IGFBP4 Protein (ABIN935568)

Target: IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Hi-5 Cells

Reinheit: > 95 % pure

Produktdetails

Sequenz: DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE

Produktmerkmale: Purified recombinant Human IGF BP4 protein
Expression System: Hi-5 cells
Bioactivity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Endotoxin-Niveau: < 0.1 ng per µg (1 EU/µg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Kommentare:

Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Antigendetails

Target: IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))

Andere Bezeichnung: IGF BP4

Hintergrund: IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF1ndependent pathway.
Alternative Names: Insulin-like Growth Factor-Binding Protein 4 protein, IGF BP-4, IGF BP 4 protein, IBP-4 protein, IGF BP4, colon cancer cell growth inhibitor protein, IGF BP-4 protein, HT29-IGF-BP protein, IGF BP-4 protein, IGF BP 4

Molekulargewicht: 25.8 kDa

Pathways: WNT Signalweg, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process