Leptin Protein (LEP)
-
- Target Alle Leptin (LEP) Proteine anzeigen
- Leptin (LEP)
- Protein-Typ
- Recombinant
-
Spezies
- Maus
-
Quelle
- Escherichia coli (E. coli)
- Applikation
- SDS-PAGE (SDS)
- Sequenz
- MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC
- Produktmerkmale
-
Purified recombinant Mouse Leptin protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. - Reinheit
- > 95 % pure
- Top Product
- Discover our top product LEP Protein
-
-
- Applikationshinweise
- Leptin protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Supplied as a liquid in PBS, pH 7.4.
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- RT/-20 °C
- Informationen zur Lagerung
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
-
- Target
- Leptin (LEP)
- Andere Bezeichnung
- Leptin (LEP Produkte)
- Hintergrund
-
Leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. Originally discovered in the mouse, the cDNA for leptin has been so far cloned from a variety of species including human, rat, cow, chicken, pig, sheep and dog. Recombinant mouse leptin was overexpressed as insoluble protein aggregate in E. coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Alternative Names: Obese protein protein, Obesity factor protein, LEP protein, OB protein, , Leptin Mouse protein, Leptin protein, OBS protein - Molekulargewicht
- 16 kDa (147 AA)
- Pathways
- JAK-STAT Signalweg, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
-