Leptin Protein (LEP)

Produktnummer ABIN934913

Dieses Recombinant Leptin-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Leptin Protein (LEP) (ABIN934913)

Target: Leptin (LEP)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Reinheit: > 95 % pure

Produktdetails

Sequenz: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC

Produktmerkmale: Purified recombinant Human Leptin protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.

Anwendungsinformationen

Applikationshinweise: Leptin protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Supplied as a liquid in PBS, pH 7.4.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Antigendetails

Target: Leptin (LEP)

Andere Bezeichnung: Leptin

Hintergrund: Human leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. The function of leptin in regulating appetite and metabolism, as well as the possibility of using leptin as a therapeutic agent, are currently under intense investigation. Recombinant human leptin was overexpressed as insoluble protein aggregate in E. coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Alternative Names: Obesity protein, OB protein, Obesity homolog mouse protein, Leptin protein, Leptin Precursor Obesity Factor protein, Obesity factor protein, Leptin protein, LEP protein, Obese protein protein, Obesity Murine Homolog Leptin protein, Leptin Murine Obesity Homolog protein, , OBS protein

Molekulargewicht: 16 kDa (147 AA)

Pathways: JAK-STAT Signalweg, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process