Caspase 1 Protein (CASP1)

Produktnummer ABIN925024

Recombinant Caspase 1-Protein exprimiert in Bacteria.

Kurzübersicht für Caspase 1 Protein (CASP1) (ABIN925024)

Target: Caspase 1 (CASP1)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Bacteria

Produktdetails

Produktmerkmale: ~8000 units/mg. One unit cleaves 1 nmol of the caspase substrate YVAD-pNA per hour at 37°C in a reaction solution containing 50 mM HEPES, pH 7.2, 50 mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10 mM DTT.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with PBS to 1 unit/µl.

Lagerung: -80 °C

Antigendetails

Target: Caspase 1 (CASP1)

Andere Bezeichnung: Caspase-1

Hintergrund: Caspase-1 (also known as ICE, Interleulin-1- Converting Enzyme) is the prototypical member of the caspase family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa pro-enzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive pro-enzyme form.

Molekulargewicht: 45 kDa

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome