PSMD10 Protein
Kurzübersicht für PSMD10 Protein (ABIN8057055)
Target
Alle PSMD10 Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Verwendungszweck
- Recombinant Human Gankyrin/PSDM10 Protein
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Sequenz
- Met 1-Gly226
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Sterilität
- 0.2 μm filtered
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Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of PBS, 10 % Glycerol, pH 7.4.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Haltbarkeit
- 6 months
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- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
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Andere Bezeichnung
- Gankyrin
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Hintergrund
- 26S Proteasome Non-ATPase Regulatory Subunit 10,26S Proteasome Regulatory Subunit p28,Gankyrin,PSMD10,p28(GANK),Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
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Molekulargewicht
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Calculated MW: 24.4 kDa
Observed MW: 26 kDa
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Gen-ID
- 5716
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UniProt
- O75832
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Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway
Target
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