SUMO1 Protein

Produktnummer ABIN7939594

Dieses Recombinant SUMO1-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für SUMO1 Protein (ABIN7939594)

Target: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant SUMO1 protein - biotinylated

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant SUMO1 protein - biotinylated is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Andere Bezeichnung: SUMO1

Hintergrund:

Protein Background: SUMO1 (Small ubiquitin-related modifier 1) is a ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1, this modulates the gating characteristics of KCNB1.

Short Description: Recombinant SUMO1 protein - biotinylated that includes full length of human SUMO1 protein (accession number NP_001005781.1) was expressed in E. coli and contains an N-terminal His & Avi tag with a molecular weight of 15.81 kDa. This protein has been modified by biotin in vivo. The purity of the protein is ≥ 95 % by SDS-PAGE.

Aliases: Small ubiquitin-related modifier 1, SMT3H3, SMT3C, GMP1, SUMO-1, UBL1, DAP1, Sentin

Pathways: M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway