EPH Receptor B4 Protein (EPHB4) (AA 561-987)

Produktnummer ABIN7938807

Dieses Recombinant EPH Receptor B4-Protein wird in Baculovirus infected Insect Cells produziert.

Kurzübersicht für EPH Receptor B4 Protein (EPHB4) (AA 561-987) (ABIN7938807)

Target: EPH Receptor B4 (EPHB4)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Screening Assay (ScA), Functional Studies (Func), Activity Assay (AcA)

Produktdetails

Proteineigenschaft: AA 561-987

Verwendungszweck: Recombinant EPHB4 (561-987) protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant EPHB4 (561-987) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: EPH Receptor B4 (EPHB4)

Andere Bezeichnung: EPHB4

Hintergrund:

Protein Background: EPHB4(Ephrin type-B receptor 4) is a Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/ functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.

Short Description: Recombinant EPHB4 (561-987) protein that includes amino acids 561-987 of human EPHB4 protein (accession number NP_004435.3) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.89 kDa.

Aliases: Ephrin type-B receptor 4, TYRO11, HTK, MYK1, Tyrosine-Protein Kinase Receptor HTK

Pathways: RTK Signalweg